Recent Advances in Cancer Cachexia

Sang Gyu Choi

doi:10.5388/jkon.2011.11.1.20

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Choi: Recent Advances in Cancer Cachexia

Original Article

Journal of Korean Oncology Nursing

Journal of Korean Oncology Nursing 2011; 11(1): 20-25.

Published online: 14 March 2011

DOI: https://doi.org/10.5388/jkon.2011.11.1.20

Recent Advances in Cancer Cachexia

Sang Gyu Choi,

Department of Radiation Oncology, Dankook University College of Medicine, Cheonan, Korea.

Address reprint requests to: Choi, Sang Gyu. Department of Radiation Oncology, Dankook University College of Medicine, 359 Manghyang-ro, Dongnam-gu, Cheonan 330-715, Korea. Tel: 82-41-550-6930, Fax: 82-41-550-6955, am2ran@gmail.com

Received 27 October 2010 Accepted 12 January 2011

Abstract

Purpose

The study was aimed to review and understand the meaning of cancer cachexia.

Methods

Using the keywords "cachexia" and "cancer cachexia" 30 oncology research published from 1974 to 2009 were selected for the review.

Results

The mechanism of cancer cachexia has not been fully understood, but various pathogenesis appears to be involved in the development cachexia including altered metabolism of carbohydrate, lipid, and protein associated with cytokines and hormone. As a result, muscle strength, food intake and resting energy expenditure (REE) are reduced. Most medications for the treatment of cachexia show debating results except some drugs such as megace. Supportive care including nutritional education, nursing care, and social support are found another effective treatment options.

Conclusion

The results of this study would help oncology nurses to understand the mechanism of cancer cachexia and its management.

Keywords: Cachexia, Cytokines

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