The Effect of Continuous Nutritional Education and Oral Mucositis Management on Nutritional Status of Patients Undergoing Hematopoietic Stem Cell Transplantation

Kyoung Soon Park; Byung Hwa Lee; Ho Ran Park

doi:10.5388/jkon.2010.10.2.119

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Park, Lee, and Park: The Effect of Continuous Nutritional Education and Oral Mucositis Management on Nutritional Status of Patients Undergoing Hematopoietic Stem Cell Transplantation

Original Article

Journal of Korean Oncology Nursing

Journal of Korean Oncology Nursing 2010; 10(2): 119-128.

Published online: 31 August 2010

DOI: https://doi.org/10.5388/jkon.2010.10.2.119

The Effect of Continuous Nutritional Education and Oral Mucositis Management on Nutritional Status of Patients Undergoing Hematopoietic Stem Cell Transplantation

Kyoung Soon Park¹, Byung Hwa Lee², Ho Ran Park³

¹Nurse, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.

²Research Associate Research Professor, Graduate School of Public Health, Yonsei University, Seoul, Korea.

³Professor, College of Nursing, The Catholic University of Korea, Seoul, Korea.

Address reprint requests to: Park, Ho Ran. College of Nursing, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea. Tel: 82-2-2258-7406, Fax: 82-2-2258-7772, hrpark@catholic.ac.kr

Received 27 January 2010 Accepted 30 July 2010

Abstract

Purpose

This study aimed to evaluate the effectiveness of continuous nutritional education and oral mucositis management on the nutritive status of patients who received hematopoietic stem cell transplantation (HSCT).

Methods

After randomly allotting 72 patients who received HSCT to either an experimental group or a control group, intensive and continuous care for preventing malnutrition was conducted in the experimental group while usual routine care was conducted in the control group. The changes of the body scale, blood chemistry profile, oral intake calories, nausea and vomitus, and oral stomatitis scores were measured at three points during their hospitalization using a oral assessment guide and nutrition analysis program: admission, HSCT, and discharge day. The differences between the scores of two groups were analyzed by repeated measures analysis of covariance.

Results

The number of total lymphocytes was significantly improved in the experimental group after transplantation (p<.001). Nausea and vomiting score was significantly decreased in the experimental group during the conditioning regimen (p<.001).

Conclusion

It was found that continuous nutritional education and oral mucositis control is an effective intervention by improving immune condition. Further investigations concerning direct examination of oral intake with controlling the effect of the chemotherapy are needed to ultimately discern the impact of varying oral nutrition patterns during HSCT.

Keywords: Hematopoietic stem cell transplantation, Education, Oral mucositis control

Figures and Tables

Fig. 1

Research framework.

Table 1

Baseline test for characteristics of HSCT patients

AML, Acute myeloid leukemia; ALL, Acute lymphocytic leukemia; MM, Multiple Myeloma; HSCT, Hematopoietic stem cell transplantation; G^*T, Group^*Time.

Table 2

Comparisons of dependent variables between two groups

⁺ANCOVA results, Gender, total fluid volume as covariate.

Exp., Experimental group (N=36); Con., Control group (N=36); G^*T, Group^*Time.

Table 3

Comparisons of dependent variables between two groups

⁺ANCOVA results, Gender, total fluid volume as covariate.

Exp, Experimental group (N=36); Cont, Control group (N=36); G^*T, Group^*Time.

Table 4

Effect of two groups⁺

⁺Multiple comparison by Bonferroni's method; ^#Differences of Least Squares means.

Standard error=^a0.5742; ^b0.1777; ^*p<.05; ^**p<.001.

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