Journal List > J Rhinol > v.23(2) > 1044373

Choi and Kim: Der p 1, Der p 2 and Der p 10 IgE Reactivities in Allergic Rhinitis Patients in Korea

Abstract

Background and Objectives

To evaluate IgE reactivity profiles to Der p 1, Der p 2, and Der p 10 in house dust mite (HDM) allergic rhinitis (AR) patients in Korea. Symptomatic and serologic changes after sublingual immunotherapy (SLIT) were analyzed according to IgE profiles.

Materials and Methods

Sixty AR patients diagnosed with an HDM allergy were tested for the presence of IgE antibodies against purified HDM allergen molecules (i.e., nDer p 1, rDer p 2, and rDer p 10) and native Dermatophagoides pteronyssinus (Dp) using ImmunoCAP 250. Symptom scores and laboratory findings were analyzed after SLIT.

Results

Prevalence rates of IgE for Dp, Der p 1, Der p 2, and Der p 10 were 100%, 98.3%, 93.3%, and 8.3%, respectively. After one year of immunotherapy with SLITone○R (standardized to major allergens, but not Der p 10), symptom scores and laboratory findings improved in patients with and without Der p 10 IgE antibodies.

Conclusion

In Korean AR patients, specific IgE antibodies to Der p 1 or Der p 2 are present in most Dp-allergic patients, while reactivity to Der p 10 is very low. Allergic symptoms improved in patients with Der p 10 IgE antibodies after SLIT.

References

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Fig. 1.
Specific IgE prevalences for Dp, Der p 1, Der p 2, and Der p 10 in proven house dust mite allergic rhinitis patients in Korea (n=60).
jr-23-91f1.tif
Fig. 2.
Total symptom score (A) and rescue medication score (B) changes after one-year sublingual immunotherapy (SLIT) in Der p 10-positive (n=5) and -negative patients (n=55). Mean scores decreased significantly after one year of SLIT in both groups. *: paired t-test, †: Wilcoxon signed rank test.
jr-23-91f2.tif
Table 1.
Demographics of patients with house dust mite-induced allergic rhinitis and their specific IgE prevalence rates
  Number of patients Percent (%)
All patients 60 100
Mean age, years (range) 18 (4–55)  
Gender    
Male 39 067
Female 21 033
Dp IgE 60 100
nDer p 1 IgE 59 098
rDer p 2 IgE 56 093
nDer p 1 or rDer p 2 IgE 59 098
rDer p 10 IgE 05 008

Dp: Dermatophagoides pteronyssinus

Table 2.
Results of ImmunoCAP 250 of the five patients with Der p 10 IgE
Patient Dp IgE (kU/L) Der p 1 IgE (kU/L) Der p 2 IgE (kU/L) Der p 10 IgE (kU/L)
1 03.17 02.07 08.56 0.026
2 27.10 21.10 29.10 0.010
3 58.50 71.70 27.80 0.033
4 25.20 07.04 37.40 0.011
5 45.90 34.40 34.50 0.014

Dp: Dermatophagoides pteronyssinus

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