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Abstract
Background and Objectives
To evaluate IgE reactivity profiles to Der p 1, Der p 2, and Der p 10 in house dust mite (HDM) allergic rhinitis (AR) patients in Korea. Symptomatic and serologic changes after sublingual immunotherapy (SLIT) were analyzed according to IgE profiles.
Materials and Methods
Sixty AR patients diagnosed with an HDM allergy were tested for the presence of IgE antibodies against purified HDM allergen molecules (i.e., nDer p 1, rDer p 2, and rDer p 10) and native Dermatophagoides pteronyssinus (Dp) using ImmunoCAP 250Ⓡ. Symptom scores and laboratory findings were analyzed after SLIT.
Results
Prevalence rates of IgE for Dp, Der p 1, Der p 2, and Der p 10 were 100%, 98.3%, 93.3%, and 8.3%, respectively. After one year of immunotherapy with SLITone○R (standardized to major allergens, but not Der p 10), symptom scores and laboratory findings improved in patients with and without Der p 10 IgE antibodies.
References
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Fig. 1.
Specific IgE prevalences for Dp, Der p 1, Der p 2, and Der p 10 in proven house dust mite allergic rhinitis patients in Korea (n=60).
Fig. 2.
Total symptom score (A) and rescue medication score (B) changes after one-year sublingual immunotherapy (SLIT) in Der p 10-positive (n=5) and -negative patients (n=55). Mean scores decreased significantly after one year of SLIT in both groups. *: paired t-test, †: Wilcoxon signed rank test.
Table 1.
Demographics of patients with house dust mite-induced allergic rhinitis and their specific IgE prevalence rates
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