Abstract
Background and Objectives
The aim of this study was to evaluate the relationship between salivary alpha-amylase (sAA) and heart rate variability (HRV) indices in SDB children based on objective parameters of polysomnography (PSG).
Materials and Method
This prospective study enrolled 67 children who underwent a physical examination and full-attended in-lab PSG with continuous electrocardiographic signal. The sAA were measured at night before PSG and in the early morning after PSG.
Results
The subjects were divided into control [n=26, apnea-hypopnea index (AHI)≤1] and obstructive sleep apnea syndrome (OSAS, n=41, AHI>1) groups; the OSAS group was subdivided into mild (1< AHI≤5), moderate (5< AHI≤10), and severe (10< AHI) groups. The severe OSAS group was significantly different from the control and other OSAS subgroups in terms of the ratio between the low- and high-frequency components (LF/HF ratio) among the HRV indices. The LF/HF ratio was positively correlated with the sAA ratio and sAA subtraction (r=0.271; r=0.347).
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Table 1.
Basic demographic, anthropometric, conventional polysomnographic date
Table 2.
The measurements regarding the sAA and HRV between the control and OSAS groups
Table 3.
The measurements regarding the sAA and HRV according to the OSA severity subgroups
Table 4.
The correlation with AHI in the OSAS group
AHI | ||
---|---|---|
r | p value | |
LF/HF ratio | 0.574 | 0.01 |
sub-sAA | 0.37 | 0.016 |
r-sAA | 0.38 | 0.013 |
Table 5.
The correlation between sAA parameters and LF/HF ratio
Total group | OSAS group | |||
---|---|---|---|---|
LF/HF ratio | LF/HF ratio | |||
r | p value | r | p value | |
sub-sAA | 0.347 | 0.005 | 0.441 | 0.005 |
r-sAA | 0.271 | 0.032 | 0.305 | 0.059 |
Table 6.
The evaluation of the effective screening parameters of LF/HF ratio and r-sAA to identify the severe OSAS group in all patients