PDF
ePub
Citation
Print
Abstract
Background and Objectives
：Sinus surgery has been reported to improve pulmonary function and decrease the use of asthma medications in patients with chronic rhinosinusitis and asthma. Most studies, however, have used a small number of patients and were conducted over a short period. To demonstrate a causal relationship between sinus surgery and asthma, a sufficient amount of patient data observed over a long period is required. To address the limitations of the existing approaches, we conducted a preliminary methodological study for large-scale data analysis using data from the National Health Insurance Service (NHIS) to suggest a basis for the effect of sinus surgery on asthma. Materials and Methods： The data from NHIS consisted of unidentified medical histories of a sample cohort representing the whole nation over a period of nine years. We selected the following types of study samples: 1) patients with surgical codes for sinus surgery; 2) patients with disease codes for sinusitis; 3) patients with disease codes for asthma; and 4) patients with medication codes for asthma treatment. Results： In this study, we applied a methodology for selection of subjects from big data to investigate the effect of sinus surgery on improving asthma in the future. We could include 152 subjects after the four-stage selection method from 1,025,340 patients. Conclusion： We could establish a method to select patients with history of sinus surgery and asthma treatment from a big data. This methodology using big data may contribute to identify relationship between sinus surgery and asthma treatment in the future.
References
1). Raghupathi W, Raghupathi V. Big data analytics in healthcare: promise and potential. Health Inf Sci Syst. 2014; 2:3.
2). iHTT Report, Transforming Health Care Through Big Data Strategies for leveraging big data in the health care industry. http://ihealth-tran.com/wordpress/2013/03/iht%C2%B2-releases-big-data-research-report-download-today/.
3). GINA Report, Global Strategy for Asthma Management and Prevention. http://www.ginasthma.org/documents/4.
4). Batra PS, Kern RC, Tripathi A, Conley DB, Ditto AM, Haines GK 3rd, et al. Outcome analysis of endoscopic sinus surgery in patients with nasal polyps and asthma. The Laryngoscope. 2003; 113:1703–6.
5). Dunlop G, Scadding GK, Lund VJ. The effect of endoscopic sinus surgery on asthma: management of patients with chronic rhinosinusitis, nasal polyposis, and asthma. American Journal of Rhinology. 1999; 13:261–5.
6). Garrel R, Gardiner Q, Khudjadze M, Demoly P, Vergnes C, Makei-eff M, et al. Endoscopic surgical treatment of sinonasal polyposis-medium term outcomes (mean follow-up of 5 years). Rhinology. 2003; 41:91–6.
7). Park AH, Lau J, Stankiewicz J, Chow J. The role of functional endoscopic sinus surgery in asthmatic patients. J Otolaryngol. 1998; 27:275–80.
8). Uri N, Cohen-Kerem R, Barzilai G, Greenberg E, Doweck I, Weiler-Ravell D. Functional endoscopic sinus surgery in the treatment of massive polyposis in asthmatic patients. J Laryngol Otol. 2002; 116:185–9.
9). Larsen K. The clinical relationship of nasal polyps to asthma. Allergy and asthma proceedings: the Official Journal of Regional and State Allergy Societies. 1996; 17:243–9.
10). Eriksson J, Bjerg A, Lötvall J, Wennergren G, Rönmark E, Torén K, et al. Rhinitis phenotypes correlate with different symptom presentation and risk factor patterns of asthma. Respir Med. 2011; 105:1611–21.
11). Lin Dc, Chandra RK, Tan BK, Zirkle W, Conley D, Grammer LC, et al. Association between severity of asthma and degree of chronic rhinosinusitis. Am J Rhinol Allergy. 2011; 25:205–8.
12). ten Brinke A, Grootendorst DC, Schmidt JT, De Bruïne FT, van Buchem MA, Sterk PJ, et al. Chronic sinusitis in severe asthma is related to sputum eosinophilia. J Allergy Clin Immunol. 2002; 109:621–6.
13). Klossek JM, Neukirch F, Pribil C, Jankowski R, Serrano E, Chanal I, et al. Prevalence of nasal polyposis in France: a cross-sectional, case-control study. Allergy. 2005; 60:233–7.
14). Downing E, Braman S, Settipane G. Bronchial reactivity in patients with nasal polyps before and after polypectomy. Journal of Allergy and Clinical Immunology. 1962; 69:102.
15). Matsuno O, Ono E, Takenaka R, Okubo T, Takatani K, Ueno T, et al. Asthma and sinusitis: association and implication. Int Arch Allergy Immunol. 2008; 147:52–8.
16). Ragab A, Clement P, Vincken W. Objective assessment of lower airway involvement in chronic rhinosinusitis. American Journal of Rhinology. 2004; 18:15–21.
17). Fokkens W, Lund V, Mullol J. European Position Paper on Rhinosinusitis and Nasal Polyps group. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinology. Supplement.
18). Ehnhage A, Olsson P, Kolbeck KG, Skedinger M, Stjarne P. One year after endoscopic sinus surgery in polyposis: asthma, olfaction, and quality-of-life outcomes. Otolaryngology–head and neck surgery: Otolaryngol Head Neck Surg. 2012; 146:834–41.
19). Proimos E, Papadakis CE, Chimona TS, Kiagiadaki D, Ferekidis E, Yiotakis J. The effect of functional endoscopic sinus surgery on patients with asthma and CRS with nasal polyps. Rhinology. 2010; 48:331–8.
20). Ragab S, Scadding GK, Lund VJ, Saleh H. Treatment of chronic rhinosinusitis and its effects on asthma. The European Respiratory Journal. 2006; 28:68–74.
21). Senior BA, Kennedy DW, Tanabodee J, Kroger H, Hassab M, Lanza DC. Long-term impact of functional endoscopic sinus surgery on asthma. Otolaryngol Head Neck Surg. 1999; 121:66–8.
22). Manning SC, Wasserman RL, Silver R, Phillips DL. Results of endoscopic sinus surgery in pediatric patients with chronic sinusitis and asthma. Arch Otolaryngol Head Neck Surg. 1994; 120:1142–5.
Table 1.
Data extraction based upon the presence of cost code of sinus surgery
Table 2.
Data extraction based upon the presence of disease code of sinusitis
Table 3.
Data extraction based upon the presence of disease code of asthma
XML Download