Cytotoxic Chemotherapy for Non-small Cell Lung Cancer

Byeong-Bae Park

doi:10.7599/hmr.2014.34.1.31

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Park: Cytotoxic Chemotherapy for Non-small Cell Lung Cancer

Review Article

Hanyang Medical Reviews 2014; 34(1): 31-36.

Published online: 25 February 2014

DOI: https://doi.org/10.7599/hmr.2014.34.1.31

Cytotoxic Chemotherapy for Non-small Cell Lung Cancer

Byeong-Bae Park

Division of Hematology/Oncology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

Correspondence to: Byeong-Bae Park. Division of Hematology/Oncology, Department of Internal Medicine, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Korea. Tel: +82-2-2229-8335, Fax: +82-2-2298-9183, bbpark@hanyang.ac.kr

Received 24 November 2013 Revised 15 January 2014 Accepted 23 January 2014

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Non-small-cell lung cancer is one of the leading causes of deaths from cancer worldwide. There have been remarkable advances in the targeted treatment of advanced non-small cell lung cancer (NSCLC) over the past several years. Survival outcomes are steadily improving as management paradigms shift in the diagnosis and treatment of advanced NSCLC. Customizing treatment based on histology and molecular typing has become a standard of care in this era of targeted therapy. Even as new chemotherapeutic agents are proving effective, a pivotal role for platinum-based chemotherapy doublets has been confirmed. Maintenance chemotherapy has become an option, but determining which patients will most benefit from it remains controversial in the real-world setting. Ongoing efforts to overcome resistance to targeted agents utilizing combination regimens of chemotherapy plus targeted agents, are currently being explored and optimized. This review highlights recent developments in novel chemotherapeutics. Despite advances in molecular medicine, there remains an essential role for chemotherapy in advanced NSCLC, even in the recent targeted therapy era.

Keywords: Carcinoma, Non-Small-Cell Lung, Chemotherapy, Adjuvant, Antineoplastic Agents

Figures and Tables

Table 1

Cytotoxic chemotherapeutic agents for non-small cell lung cancer

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