Head and Neck Squamous Cell Carcinoma: Genetic Polymorphisms and Occurrence Risks

Kyung Tae

doi:10.7599/hmr.2013.33.3.170

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Tae: Head and Neck Squamous Cell Carcinoma: Genetic Polymorphisms and Occurrence Risks

Review Article

Hanyang Medical Reviews 2013; 33(3): 170-177.

Published online: 21 August 2013

DOI: https://doi.org/10.7599/hmr.2013.33.3.170

Head and Neck Squamous Cell Carcinoma: Genetic Polymorphisms and Occurrence Risks

Kyung Tae

Department of Otolaryngology-Head and Neck Surgery, Hanyang University College of Medicine, Seoul, Korea.

Correspondence to: Kyung Tae. Department of Otolaryngology-Head and Neck Surgery, Hanyang University Hospital, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-792, Korea. Tel: +82-2-2290-8585, Fax: +82-2-2293-3335, kytae@hanyang.ac.kr

Received 7 July 2013 Revised 29 July 2013 Accepted 6 August 2013

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Head and neck squamous cell carcinoma (HNSCC), which is the 5th most common cancer worldwide, is believed to be induced by environmental carcinogens and host genetic factors. The main etiologic environmental factors are tobacco, alcohol, viral infection, nutritional deficit, mineral inhalation and history of radiation exposure. Accumulating evidence has shown that genetic polymorphisms influence the risk of environmental carcinogenesis, and that genetic susceptibility plays an important role in the development of HNSCC. Genetic susceptibility to HNSCC may be due to genetic polymorphisms in genes controlling both carcinogen metabolism and repair of DNA damage. We analyzed the associations between genetic polymorphisms in the xenobiotics metabolizing gene, alcohol metabolizing gene and DNA repair genes and the risk of HNSCC in an at-risk Korean population. In conclusion, ADH1B +3170A>G His48Arg and XRCC1 R194W (C>T) polymorphism are associated with an increased risk of HNSCC, and these genotypes could be useful biomarkers for identifying Koreans with a greater risk of HNSCC.

Keywords: Polymorphism, Genetic, Head and Neck Neoplasms, Cytochrome P-450 CYP1A1, DNA Repair

Figures and Tables

Table 1

Genetic polymorphism of xenobiotic metabolism gene, alcohol metabolism gene, and DNA repair gene and risk of head and neck squamous cell carcinoma

OR (95% CI); odds ratios (95% confidential interval).

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