Recent Advances in Obesity Research and Management

Dae Ho Lee

doi:10.7599/hmr.2012.32.4.213

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Lee: Recent Advances in Obesity Research and Management

Review Article

Hanyang Medical Reviews

Hanyang Medical Reviews 2012; 32(4): 213-218.

Published online: 28 November 2012

DOI: https://doi.org/10.7599/hmr.2012.32.4.213

Recent Advances in Obesity Research and Management

Dae Ho Lee

Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.

Corresponding author: Dae Ho Lee. Department of Internal Medicine, Jeju National University School of Medicine, 102 Jejudaehak-ro, Jeju 690-756, Korea. Tel: +82-64-717-1521, Fax: +82-64-717-1131, drdhkso@hanmail.net

Received 7 August 2012 Revised 19 October 2012 Accepted 26 October 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Obesity is at epidemic proportions worldwide. Obesity is a significant risk factor for cardiovascular disease, diabetes, cancer and other chronic diseases. Initial lifestyle modification may be intended to induce 7-10% decrease in baseline body weight in obese subjects. Drug therapy can be introduced for subjects with a BMI≥30 kg/m² or in those with a BMI ≥27 kg/m² when comorbidities, such as hypertension or type 2 diabetes mellitus, are present. Bariatric surgery is widely available and can be performed for individuals with a BMI ≥40 kg/m² (or for patients with a BMI≥35 kg/m² and comorbidities) who are unsuccessful with other therapies. Recently, many basic research findings showed that inflammatory responses to metabolic dysfunctions are key pathophysiologic changes in obesity and insulin resistance. Further studies will be required to find out effective targets to manage obesity and to resolve various unanswered issues about diet and exercise regimens. Furthermore, more data about bariatric surgeries are required.

Keywords: Obesity, Insulin Resistance, Inflammation, Anti-Obesity Agents, Bariatric Surgery

Figures and Tables

Table 1

Summarized Effects of Low-Dose, Controlled-Release, Phentermine Plus Topiramate Combination on in Overweight and Obese Adults (CONQUER): a Randomised, Placebo-Controlled, Phase 3 Trial

Table 2

The Bariatric Surgeries and Their Outcomes

RYGB, Roux-en-Y gastric bypass; LAGB, laparoscopic adjustable gastric banding; LSG, laparoscopic sleeve gastrectomy; BPD/DS, biliopancreatic diversion with or without duodenal switch.

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