Current Status and Therapeutic Perspectives for the Stem Cells Treatment of Ischemic Stroke

Hyun Young Kim

doi:10.7599/hmr.2012.32.3.134

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Kim: Current Status and Therapeutic Perspectives for the Stem Cells Treatment of Ischemic Stroke

Review Article

Hanyang Medical Reviews

Hanyang Medical Reviews 2012; 32(3): 134-140.

Published online: 24 August 2012

DOI: https://doi.org/10.7599/hmr.2012.32.3.134

Current Status and Therapeutic Perspectives for the Stem Cells Treatment of Ischemic Stroke

Hyun Young Kim

Department of Neurology, Hanyang University College of Medicine, Seoul, Korea.

Corresponding author (hyoungkim1@hanyang.ac.kr)

Received 23 June 2012 Accepted 26 July 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent attention has focused on the use of stem cells for therapy following ischemic stroke. Our understanding of brain injury following ischemic stroke has benefitted from a number of studies elucidating the causes and pathways leading to neuronal injury and death after anoxic insult. Other paths of research have provided the technology to create and manipulate stem cells along specific neuronal pathways. Therefore, researchers and clinicians have begun basic studies in the use of stem cell therapies to limit injury to the central nervous system and repair and regenerate injured neural tissues following hypoxia due to stroke. These therapies are showing promise and potential in improving the outcome of the stroke patient. This review covers our current knowledge and views concerning mechanisms of tissue damage following ischemic stroke, and the mechanisms by which stem cell therapy is predicted to benefit patients facing potential brain damage and loss of function. Recent reports of clinical trials using stem cells for stroke therapy are evaluated and critical points requiring further work and research are discussed.

Keywords: Stem Cells, Brain Ischemia, Transplantation

Figures and Tables

Table 1

Completed Clinical Stem Cell Trials for Stroke

NT2N, human neuroteratocarcinoma; BMSC, bone marrow-derived mesenchymal stem cell; IC, intracerebral injection; IV, intravenous injection; IS, ischemic stroke; HS, hemorrhagic stroke.

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