The Role of Transient Receptor Potential Channel in Pain

Seung Jun Jung

doi:10.7599/hmr.2011.31.2.116

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Jung: The Role of Transient Receptor Potential Channel in Pain

Review Article

Hanyang Medical Reviews

Hanyang Medical Reviews 2011; 31(2): 116-122.

Published online: 31 May 2011

DOI: https://doi.org/10.7599/hmr.2011.31.2.116

The Role of Transient Receptor Potential Channel in Pain

Seung Jun Jung, M.D., Ph.D.

Department of Physiology, Hanyang University College of Medicine, Seoul, Korea.

Corresponding author (eurijj@naver.com)

Received 8 April 2011 Accepted 6 May 2011

Abstract

Transient receptor potential (TRP) channels, a large family of receptor channel proteins, initially attracted researchers in the pain field as key molecules in nociception, but later they became known as more general transducer molecules for various physical stresses. In this review, I will discuss their roles in thermal and mechanical sensation, and then consider their contribution to physiological pain.

Keywords: Pain, Transient receptor potential channels, Thermo-sensor, Mechano-sensor, Transducer

Figures and Tables

Fig. 1

Temperature thresholds, chemical agonists, and tissue distribution of six temperature-sensitive TRP channels. NADA, N-arachidonoyl-dopamine; 2-APB, 2-aminoethoxydiphenyl borate; DPBA, diphenylboronic anhydride; 4α-PDD, 4α-phorbol 12,13-didecanoate; PMA, phorbol 12-myristate 13-acetate; PtdIns (4,5)P₂, phosphatidylinositol 4,5-bisphosphate; HNE, 4-hydroxynonenal; THC, tetrahydrocannabinol.30

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