Journal List > Korean J Nutr > v.43(1) > 1043820

So, Kim, Jung, and Park: Analysis of the Factors Relating Nutritional Status in Discharging of Leukemia Patients Receiving Chemotherapy

Abstract

This study was performed to investigate the changes of oral diet intake during the admission period and identify the factors related with nutritional status in discharging of leukemia patients. This is a retrospective cross sectional study on 46 leukemia patients receiving chemotherapy at the Catholic University of Korea Seoul St. Mary's Hospital from July to September 2009. The patients' charts were surveyed on the general characteristics and factors relating chemotherapy. The calorie count method was used to investigate diet intake during admission period. Multivariate logistic regression analysis was used to identify possible confounding factors. A p < 0.05 was considered statistically significant. The mean age was 42.8 ± 14.6 years and the average length of stay was 30.4 ± 7.0 days. The incidence of malnourished patients was 60.9% in discharging. There was a significant difference in chemotherapy sessions and chemotherapy period between well-nourished and malnourished patients. The average energy intake was 1,525.9 kcal in well-nourished patients and 1,143 kcal in malnourished patients, which was significant different. From repeated measures ANOVA test, the changes of oral intake during admission period were significant by groups. In addition, there were significant differences in oral intake according to each period between well-nourished and malnourished patients. In multivariate logistic regression analysis, both the ratio of total oral energy intake to recommended energy intake and chemotherapy sessions were significantly associated with nutritional status in discharging. The results of this study could be used to establish a protocol of nutritional management for leukemia patients receiving chemotherapy.

Figures and Tables

Table 1
General characteristics of subjects (n = 46)
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1) Percentage ideal body weight in discharging

2) Serum albumin in discharging

3) Weight loss from admission to discharge

4) Significantly different between no malnutrition present group and malnutrition group by Student t-test (**: p < 0.01)

5) Significantly different between no malnutrition present group and malnutrition group by Likelihood ratio test (*: p < 0.05)

Table 2
Oral intake status by the nutritional status in discharging
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1) Significantly different between no malnutrition present group and malnutrition group by Student t-test (*: p < 0.05)

2) Significantly different between no malnutrition present group and malnutrition group by Student t-test (**: p < 0.01)

Table 3
Change of oral intake during chemotherapy period by the nutritional status in discharging
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1) No malnutrition present

2) Malnutrition

3) Significantly different between no malnutrition present group and malnutrition group by Student t-test (*: p < 0.05)

4) Significantly change of oral intake over time between no malnutrition present group and malnutrition group by Repeated measures ANOVA between-subject's effects (**: p < 0.01)

Table 4
Logistic regression model for variables affecting the nutritional status in discharging
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1) Significantly different between no malnutrition present group and malnutrition group by Logistic regression analysis (*: p < 0.05)

2) Significantly different between no malnutrition present group and malnutrition group by Logistic regression analysis (**: p < 0.01)

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