Journal List > Korean J Pediatr Gastroenterol Nutr > v.14(1) > 1043531

Korean J Pediatr Gastroenterol Nutr. 2011 Mar;14(1):67-73. Korean.
Published online March 31, 2011.  https://doi.org/10.5223/kjpgn.2011.14.1.67
Copyright © 2011 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
An Epidemiologic Study on the Seropositive Rate of Hepatitis A Virus in Children of Gwangju and Jeonnam
Ji Jung, M.D., Young Joon Ahn, M.D.,* and Kyung Rye Moon, M.D.
Department of Pediatrics, School of Medicine, Chosun University, Gwangju, Korea.
*Department of Medical Education, School of Medicine, Chosun University, Gwangju, Korea.

Corresponding author (Email: krmoon@chosun.ac.kr )
Received February 01, 2011; Revised February 26, 2011; Accepted March 01, 2011.

Abstract

Purpose

Recently, the incidence of acute hepatitis A has increased nationwide and is related to a low rate of IgG anti-HAV production. To establish effective measures for preventing hepatitis A virus infection, an epidemiologic study on the seroprevalence of anti-HAV is needed. Thus, we investigated the seroprevalence of IgG anti-HAV in children living in Gwangju and Jeonnam.

Methods

IgG anti-HAV levels were measured in a total of 1,435 patients who visited Chosun University Hospital between January 2009 and December 2009.

Results

The overall seropositve rate was 40.8% (586/1,435). The seropositive rates were 41% among children under the age of 1 year, 49.9% for children 1~5 years old, 51.1% among individuals 5~10 years old, 12.9% for individuals 10~15 years old, and 8.2% for subjects over 15 years old. There was no significant difference between genders in any group. The seropositive rates in Gwangju and Jeonnam were 57.3% and 32.9% for children under the age of 1 year, 52.5% and 44.3% for children 1~5 years old, 60.2% and 33.9% among children 5~10 years old, 14.1% and 9.7% for children 10~15 years old, and 10.8% and 4.2% for individuals over 15 years old.

Conclusion

The results demonstrated the low rates of IgG anti-HAV, particularly among subjects over 10 years old, which suggests the possibility of increasing clinical HAV infection rates among adults in the near future. We should actively prevent the spread of hepatitis A virus. Vaccination is the most effective means of preventing hepatitis A virus transmission among persons at risk for infection. Hepatitis A vaccination is recommended for children who have low IgG anti-HAV seropositive rates.

Keywords: Hepatitis A virus; Seroprevalence

Figures


Fig. 1
The age related prevalence of IgG anti-HAV titers (years).
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Fig. 2
The age related prevalence of IgG anti-HAV titers (months).
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Fig. 3
Comparing the prevalence of IgG anti-HAV between Gwangju and Jeonnam.
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Tables


Table 1
The Age Related Prevalence of IgG Anti-HAV (years)
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Table 2
The Age Related Prevalence of IgG Anti-HAV (months)
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Table 3
The Gender Related Prevalence of IgG Anti-HAV (years)
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Table 4
Comparing the Prevalence of IgG Anti-HAV between Gwangju and Jeonnam
Click for larger image

References
1. Cuthbert JA. Hepatitis A: old and new. Clin Microbiol Rev 2001;14:38–58.
2. Hong WS, Kim CY. Seroepidemoiology of type A and type B hepatitis in Seoul Area. Korean J Intern Med 1982;25:19–26.
3. Choi W, Eom HS, Kim IH, Lee DH, Kim PS, Kim HG, et al. Patterns of acute hepatitis A and anti-HAV sero-prevalence of Kyungin Province. Korean J Gastroenterol 1999;34:69–75.
4. Kim NJ, Sung JK, Lee SW. An outbreak of hepatitis A in Taejeon city. Korean J Gastroenterol 1999;34:205–212.
5. Glikson M, Galun E, Oren R, Tur-Kaspa R, Shouval D. Relapsing hepatitis A. Review of 14 cases and literature survey. Medicine 1992;71:14–23.
6. Advisory Committee on Immunization Practices (ACIP). Fiore AE, Wasley A, Bell BP. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2006;55:1–23.
7. Hadler SC, Webster HM, Erben JJ, Swanson JE, Maynard JE. Hepatitis A in day care centers. A community-wide assessment. N Engl J Med 1980;302:1222–1227.
8. Choi HJ, Lee SY, Ma SH, Kim JH, Hur JK, Kang JH. Age related prevalence of antibodies to hepatitis A virus performed in Korea in 2005. Korean J Pediatr Infect Dis 2005;12:186–194.
9. Feinstone SM, Kapikian AZ, Purceli RH. Hepatitis A:detection by immune electron microscopy of a viruslike antigen associated with acute illness. Science 1973;182:1026–1028.
10. Moon KR. Hepatitis A. Korean J Pediatr Gastroenterol Nutr 2008;11:44–49.
11. Youn HS. Current status of hepatitis A virus infections in Korea. Korean J Pediatr 2008;51:690–695.
12. Nelson KE. Global changes in the epidemiology of hepatitisA virus infections. Clin Infect Dis 2006;42:1151–1152.
13. Centers for Disease Control and Prevention. Prevention of hepatitis A through active or passive immunization: Recommendation of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 1999;48(RR-12):1–37.
14. Kim CY, Hong WS. Seroepidemiology of type A and type B hepatitis in Seoul area. Korean J Intern Med 1982;25:19–27.
15. Lee JI, Kim JY, Kim ST, Yoo SY, Chung SM, Kim YK, et al. Epidemiologic study of antibody to hepatitis A antigen in Choong Chung area. Korean J Gastroenterol 1982;14:87–91.
16. Kim TW, Lee KJ. Antibody of hepatitis A antigen in children and adolescents in Korea. J Korean Pediatr Soc 1982;25:36–40.
17. Lee KY, Song KH, Kang JH. Seroepidemiology of hepatitis A in Taejon, Korea 1996. J Korean Pediatr Soc 1998;41:53–61.
18. Park CH. Changes in teh age-specific prevalence of hepatitis A virus antibodies: a 10 year cohort study in Jinju, South Korea. Clin Infect Dis 2006;42:1148–1150.
19. Kim SY. Concordance of Seropositivity between Helicobacter pylori and Hepatitis A virus IgG in children of Gwangju and Chonnam Area. Korean J Pediatr Gastroenterol Nutr 2001;4:191–198.
20. Kim H, Kim JH, Kim DH, Heo JK, Lee WB, Seo BK, et al. Epidemiologic changes and clinical features of hepatitis A in children; living in Kyung-gi province, since 1988 to 1998. Korean J Pediatr Infect Dis 1998;5:230–236.
21. Duval B, De Serres G, Ochnio J, Scheifele D, Gilca V. Nationwide Canadian study of hepatitis A antibody prevalence among children eight to thirteen years old. Pediatr Infect Dis J 2005;24:514–519.
22. Song YB, Lee JH, Choi MS, Koh KC, Paik SW, Yoo BC, et al. The age-specific seroprevalence of hapatitis A virus antibody in Korea. Korean J Hepatol 2007;13:27–33.
23. CDC. Prevention of hepatitis A through active or passive immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2006;55:1–23.