Journal List > Korean J Pediatr Gastroenterol Nutr > v.14(1) > 1043528

Korean J Pediatr Gastroenterol Nutr. 2011 Mar;14(1):45-51. Korean.
Published online March 31, 2011.
Copyright © 2011 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Antimicrobial Resistance of Helicobacter pylori Isolated from Korean Children
Yoo Mi Kim, M.D., Yeoun Joo Lee, M.D., Seak Hee Oh, M.D., Heungsup Sung, M.D.,* Mi-Na Kim, M.D.,* and Kyung Mo Kim, M.D.
Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
*Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Corresponding author (Email: )
Received August 13, 2010; Revised September 08, 2010; Accepted September 08, 2010.



The antimicrobial resistance of Helicobacter pylori is one of the critical factors in failure of eradication therapy. The purpose of this study was to evaluate antimicrobial resistance of H. pylori in Korean children.


Gastric mucosal specimens for H. pylori were obtained from children with dyspepsia who were cared for at Asan Medical Center Children's Hospital in Seoul, Korea between 2003 and 2009. Antimicrobial resistance tests were performed using the disk diffusion method for clarithromycin and amoxicillin and the E-test for metronidazole and tetracycline. Most children with H. pylori infections were treated using triple therapies.


Thirty-three children had positive H. pylori cultures, although a resistance test was only performed in 28 patients. Resistant strains were found in 9 children (32.1%). The resistance rates to clarithromycin and metronidazole were 25% and 17.8%, respectively. There was no resistance to amoxicillin or tetracycline. The resistance rates decreased from 44.4% (2003~2006) to 26.3% (2006~2009) during the study period.


Korean children demonstrated relatively high antimicrobial resistance to H. pylori in this study. However, there was a temporarily decreasing trend during the study period. A larger multi-regional study may be needed to determine the optimal antimicrobial treatment for pediatric patients infected with H. pylori.

Keywords: Helicobacter pylori; Antimicrobial resistance; Korea; Children


Table 1
Age, Gender and Geographical Distribution of Patients according to Antimicrobial Resistance
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Table 2
Resistance Rates of Antibiotics in Helicobacter pylori Infection (July 2003~April 2009)
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Table 3
Eradication Rate according to the Antimicrobial Resistance and Type of Treatment Modality
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