Journal List > Korean J Pediatr Gastroenterol Nutr > v.14(1) > 1043495

Korean J Pediatr Gastroenterol Nutr. 2011 Mar;14(1):1-25. Korean.
Published online March 31, 2011.  https://doi.org/10.5223/kjpgn.2011.14.1.1
Copyright © 2011 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Pediatric Inflammatory Bowel Disease (IBD): Phenotypic, Genetic and Therapeutic Differences between Early-Onset and Adult-Onset IBD
Jeong Kee Seo, M.D.
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Corresponding author (Email: jkseo@snu.ac.kr )
Received March 02, 2011; Revised March 21, 2011; Accepted March 25, 2011.

Abstract

Inflammatory bowel disease (IBD) develops during childhood or adolescence in approximately 25% of patients with IBD. Recent studies on pediatric IBD have revealed that early-onset IBD has distinct phenotype differences compared to adult onset IBD. Pediatric early-onset IBD differs in many aspects including disease type, location of the lesions, disease behavior, gender preponderance and genetically attributable risks. This review examines the currently published data on the clinical, epidemiological and genetic differences between early-onset and adult-onset IBD. And finally, therapeutic considerations in the management of pediatric-onset IBD are also discussed.

Keywords: Pediatric inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Early onset

Tables


Table 1
Montreal and Paris Classifications for CD19)
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Table 2
Montreal and Paris Classifications for UC19)
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Table 3
CD:UC Ratio in Pediatric IBD and Adult IBD
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Table 4
Male Preponderance in Pediatric CD
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Table 5
Pancolitis Predominance in Pediatric UC
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Table 6
High Prevalence of Ileocolonic Disease in Pediatric CD
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Table 7
Phenotypes and Disease Progression Behavior in Pediatric CD
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Table 8
Pediatric Crohn's Disease Activity Index
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Table 9
Pediatric Ulcerative Colitis Activity Index
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Table 10
Suggested Classification Paradigm for Documenting Linear Growth Impairment in Pediatric Onset IBD
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