Journal List > Korean J Pediatr Gastroenterol Nutr > v.13(Suppl 1) > 1043490

Korean J Pediatr Gastroenterol Nutr. 2010 Dec;13(Suppl 1):S32-S43. Korean.
Published online December 31, 2010.
Copyright © 2010 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
The Diagnosis of Food Allergy in a Pediatric Gastroenterology: Focusing on Non-IgE-mediated Allergic Diseases
Kun Song Lee, M.D.
Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Korea.

Corresponding author (Email: )
Received November 24, 2010; Accepted November 30, 2010.


Food allergy is an adverse immune response to foods. The prevalence of food allergy vary by age, diet, and many other factors. Based on the immunological mechanism, food allergies may be classified in a IgE-mediated diseases, which are the best-characterized food allergy reactions, non-IgE-medicated diseases, and mixed type diseases. In children, the GI tract seems to be the most common target organ. Generally, IgE-mediated reactions have an acute onset, whereas non-IgE-mediated reactions have a late onset. The most food allergy with GI manifestation involve non-IgE-mediated reactions. The evaluation of a child with suspected food allergy includes medical history, physical examination, screening test and the response to elimination diet and to oral food challenge. The diagnosis of non-IgE-mediated food allergies using a screening test is difficult. In this review, investigate the diagnostic criteria and manifestations of several non-IgE-mediated allergic diseases and the diagnostic method in the field of a pediatric gastroenterology.

Keywords: Food allergy; Non-IgE-mediated reactions; Pediatric gastroenterology


Fig. 1
Evaluation of a child with suspected food allergy.
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Fig. 2
Measurement for skin prick test.
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Fig. 3
Procedures for diagnosis of eosinophilic esophagitis.
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Fig. 4
Algorithm after oral cow's milk challenge for diagnosis of typical cow's milk protein-induced enterocolitis. Adapted from ref. 26.
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Fig. 5
Selection of type of food challenge according to age and symptoms. Adapted from ref. 22.
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Table 1
Classification of Gastrointestinal Hypersensitivities to Food and Other Dietary Products
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Table 2
The Seven Groups of Gastrointestinal Cow Milk Allergy in Infants
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Table 3
Principal Characteristics of Allergic Proctocolitis
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Table 4
Principal Characteristics of Food-Induced Enterocolitis Syndrome
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Table 5
Most common Age-Related Clinical Manifestations of EOE
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Table 6
Classification of Eosinophilic Gastroenteritis
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Table 7
Major Symptoms of Eosinophilic Gastroenteritis Depending on the Localization of Disease
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Table 8
Clinical Features Suggestive of Food Protein-Induced Gastrointestinal Motility Disorders In Infants and Young Children
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Table 9
Grading System for Skin Prick Test
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Table 10
Predictive Values of Food Allergen-Specific Immunoglobulin E Levels
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Table 11
Diagnostic Guideline of Esosinophilic Esophagitis
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Table 12
Histologic Features Associated with EE
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Table 13
Oral food challenge in food protein-induced enterocolitis syndrome
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