Journal List > Korean J Pediatr Gastroenterol Nutr > v.13(Suppl 1) > 1043489

Korean J Pediatr Gastroenterol Nutr. 2010 Dec;13(Suppl 1):S25-S31. Korean.
Published online December 31, 2010.  https://doi.org/10.5223/kjpgn.2010.13.Suppl1.S25
Copyright © 2010 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Update on Genetic Studies of Functional Gastrointestinal Disorders
Ji Hyun Uhm, M.D.
Department of Pediatrics, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea.

Corresponding author (Email: eomjie@eulji.ac.kr )
Received November 24, 2010; Accepted November 30, 2010.

Abstract

Childhood functional gastrointestinal disorders are defined as a variable combination of often age-dependent, chronic, or recurrent gastrointestinal symptoms not explained by structural or biochemical abnormalities. A better understanding of genetic background of these disorders would help to better identify their complex biology and make it possible to identify subgroups of patients who respond to customized therapies. Family and twin studies have shown a genetic component in irritable bowel syndrome. Candidate gene studies have identified a few genetic polymorphisms that may be associated with functional dyspepsia and irritable bowel syndrome. Studies of associations of spontaneous genetic variations and altered functions may provide novel insights of the mechanisms contributing to the disease.

Keywords: Irritable bowel syndrome; Functional dyspepsia; Candidate genes; Intermediate phenotypes

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