Update on Genetic Studies of Functional Gastrointestinal Disorders

Ji Hyun Uhm

doi:10.5223/kjpgn.2010.13.Suppl1.S25

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Uhm: Update on Genetic Studies of Functional Gastrointestinal Disorders

Review Article

Korean Journal of Pediatric Gastroenterology and Nutrition

Korean Journal of Pediatric Gastroenterology and Nutrition 2010; 13(Suppl 1): S25-S31.

Published online: 31 December 2010

DOI: https://doi.org/10.5223/kjpgn.2010.13.Suppl1.S25

Update on Genetic Studies of Functional Gastrointestinal Disorders

Ji Hyun Uhm, M.D.

Department of Pediatrics, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea.

Corresponding author (eomjie@eulji.ac.kr)

Received 24 November 2010 Accepted 30 November 2010

Abstract

Childhood functional gastrointestinal disorders are defined as a variable combination of often age-dependent, chronic, or recurrent gastrointestinal symptoms not explained by structural or biochemical abnormalities. A better understanding of genetic background of these disorders would help to better identify their complex biology and make it possible to identify subgroups of patients who respond to customized therapies. Family and twin studies have shown a genetic component in irritable bowel syndrome. Candidate gene studies have identified a few genetic polymorphisms that may be associated with functional dyspepsia and irritable bowel syndrome. Studies of associations of spontaneous genetic variations and altered functions may provide novel insights of the mechanisms contributing to the disease.

Keywords: Irritable bowel syndrome, Functional dyspepsia, Candidate genes, Intermediate phenotypes

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