Journal List > Korean J Pediatr Gastroenterol Nutr > v.13(1) > 1043484

Korean J Pediatr Gastroenterol Nutr. 2010 Mar;13(1):81-85. Korean.
Published online March 31, 2010.
Copyright © 2010 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Melanosis Coli Associated with Aloe Consumption in a Child
Jeong Ok Shim, M.D., and Seung Koo Lee, M.D.*
Department of Pediatrics, Kangwon National University School of Medicine, Chuncheon, Korea.
*Department of Pathology, Kangwon National University School of Medicine, Chuncheon, Korea.

Responsible author (Email: )
Received February 03, 2010; Accepted March 08, 2010.


Melanosis coli is described as a black or brown discoloration of the mucosa of the colon. Such a discoloration is largely due to pigment granule deposition in macrophages in the colonic mucosa, which arises from anthraquinone-containing laxative abuse. Melanosis coli has usually been reported in the elderly. We present the first case of melanosis coli associated with aloe consumption in a Korean child.

Keywords: Melanosis coli; Child; Anthraquinone; Laxative


Fig. 1
Colonoscopic finding shows brown pigmentation with aggregates of lymphoid follicles in the rectum and sigmoid (A, B). Patchy intense pigmentation, as well as focal areas of absent pigment in a reticulated pattern, were also noted (C).
Click for larger image

Fig. 2
Light microscopic finding shows the brown pigment granule-laden macrophages (arrows) in the submucosa (A) (H&E stain, ×40) and in the lamina propria (B) (H&E stain, ×200).
Click for larger image

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