Journal List > Korean J Pediatr Gastroenterol Nutr > v.13(1) > 1043477

Korean J Pediatr Gastroenterol Nutr. 2010 Mar;13(1):44-50. Korean.
Published online March 31, 2010.
Copyright © 2010 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Experience with Entecavir Therapy for Lamivudine-Resistant Chronic Hepatitis B in Korean Children and Adolescents
Seung Man Cho, M.D., Byung-Ho Choe, M.D., Mi Ae Chu, M.D. and Jung-Mi Kim, M.D.
Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.

Responsible author (Email: )
Received February 02, 2010; Accepted March 04, 2010.



To estimate the viral suppressive effect of entecavir monotherapy in Korean children and adolescents with lamivudine-resistant chronic hepatitis B (CHB).


One milligram of entecavir was administered once daily to 6 patients (4 boys; mean age, 17.5 years; range, 15.10~24.6 years) with lamivudine-resistant CHB for a mean duration of therapy of 13.4 months (range, 1~21.1 months). The therapeutic results were compared with 11 patients who received adefovir (0.3 mg/kg/day [maximal dose 10 mg]) for at least 12 months (mean, 33.4 months; range, 12.4~58.3 months). The serum HBV DNA level and serologic markers were measured every 2 months.


The interval to a HBV DNA titer decrement (>1 log10) was 1.2±0.2 and 4.4±5.2 months (p=0.185) for the entecavir and adefovir groups, respectively. The interval to a HBV DNA titer decrement (>2 log10) was 2.4±2.3 and 9.2±7.3 months (p=0.025), for the entecavir and adefovir groups, respectively.


The therapeutic efficacy of entecavir was favorable in children and adolescents, especially in shortening the interval to a >2 log10 decrement in the HBV DNA titer. Long-term follow up is needed to determine the therapeutic efficacy of entecavir for lamivudine-resistant CHB in children and adolescents.

Keywords: Entecavir; Adefovir; Lamivudine; Chronic hepatitis B; Resistance


Table 1
Baseline Characteristics of Patients
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Table 2
Comparison of the Position of the Mutation in the YMDD Motif
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Table 3
Therapeutic Response of Patients Based on the Decrement in HBV DNA Titer
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Table 4
Comparison of Treatment Results between the ETV and ADV Groups
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