Journal List > Korean J Pediatr Gastroenterol Nutr > v.13(1) > 1043474

Korean J Pediatr Gastroenterol Nutr. 2010 Mar;13(1):23-29. Korean.
Published online March 31, 2010.
Copyright © 2010 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Clinical Significance of Coagulation Screening Tests and Platelet Counts in Children Undergoing Endoscopy
Eun Hye Lee, M.D., Hye Ran Yang, M.D., Jae Sung Ko, M.D. and Jeong Kee Seo, M.D.
Division of Gastroenterology and Nutrition, Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Corresponding author (Email: )
Received February 09, 2010; Accepted March 07, 2010.



The aim of this study was to assess the benefits of routine pre-endoscopy coagulation screening tests and platelet counts in Korean children.


Between March 2004 and December 2009, children who underwent gastrointestinal endoscopy for the evaluation of various gastrointestinal symptoms were included. All of the subjects included in the study also underwent routine coagulation screening and platelet count determinations prior to endoscopy and biopsy. The clinical records and laboratory tests were retrospectively reviewed in all patients.


One hundred sixty-two of 1,476 (11%) patients who underwent endoscopy had abnormal results on pre-screening coagulation tests. Fourteen patients underwent coagulation factor assays due to abnormal clotting results in consecutive tests or due to clinical evidence of a bleeding tendency. Seven patients were diagnosed with factor XII deficiency, one patient was diagnosed with von Willebrand disease, one patient had von Willebrand disease and factor XII deficiency, and one patient was presumed to have mild hemophilia. The remaining 4 patients had normal results with the factor assays. The results of platelet counts were normal with the exception of 1 patient. No patient had significant bleeding during the endoscopic procedures, despite abnormal pre-endoscopic coagulation tests.


Routine coagulation screening tests and platelet counts revealed abnormal results in some patients. Most of the patients with abnormal clotting were shown to have a factor XII deficiency, which had no significant associated bleeding tendencies; the other patients were diagnosed with hemophilia or von Willebrand disease. Therefore, although abnormal pre-endoscopic coagulation is not always related to significant bleeding complications, pre-endoscopic coagulation screening may be useful in some children in predicting the risk of bleeding tendency during endoscopic procedures.

Keywords: Gastrointestinal endoscopy; Coagulation test; Platelet count; Factor deficiency; Children


Table 1
Abnormal Results of Pre-endoscopic Coagulation Screening Tests
Click for larger image

Table 2
Results of Factor Assays
Click for larger image

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