Treatment of relapsed hyperthyroidism

Jae Hoon Chung

doi:10.5124/jkma.2018.61.4.248

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Chung: Treatment of relapsed hyperthyroidism

Original Article

J Korean Med Assoc 2018;61(4):248-252.

Published online: 17 April 2018

DOI: https://doi.org/10.5124/jkma.2018.61.4.248

Treatment of relapsed hyperthyroidism

Jae Hoon Chung, MD^1,²

¹Division of Endocrinology & Metabolism, Department of Internal Medicine, Seoul, Korea

²Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Corresponding author: Jae Hoon Chung E-mail: thyroid@skku.edu

Received 6 March 2018 Accepted 20 March 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Graves disease is the most common disease that causes hyperthyroidism. It is an autoimmune disease characterized by the overproduction of thyroid hormones due to continuous stimulation of the thyroid gland by thyroid-stimulating hormone receptor antibody. Therapeutic modalities for Graves disease include antithyroid drugs (ATDs), radioactive iodine, and thyroidectomy. ATDs are the most preferred therapeutic option by physicians in most countries except North America. However, current treatment strategies are unfortunately aimed at inhibiting thyroid hormone production or ablating the thyroid to induce permanent hypothyroidism, not at inhibiting thyroid-stimulating hormone receptor antibody. ATD therapy has a high relapse rate (more than 50%), and morbidity and mortality increase in cases of relapse. Therefore, the proper and prompt management of relapsed patients is very important.

Keywords: Hyperthyroidism, Recurrence, Antithyroid agents, Iodine radioisotopes, Thyroidectomy

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