Journal List > J Korean Med Assoc > v.55(6) > 1042578

Kim and Hwang: The dietary therapy and use of probiotics in the treatment of pediatric acute diarrhea

Abstract

In the process of medical care of acute diarrhea in children, two pathophysiologic aspects should be considered: dehydration associated with electrolyte imbalance, and nutritional disorder. It is important to continue to provide foods easy to digest with appropriate recipes from the early stage after a remedy of dehydration using oral rehydration solution or intravenous fluid therapy according to patients' condition. Nil per os or diluted diet can slow the recovery of an intestinal function and lengthen the diarrheal period. Although the damage on the intestinal mucosa occurs from various causes, the gastrointestinal mucosa maximizes absorbing capacity by expanding the area of a surface. Early oral-feeding contributes to restoring mucosa favorably and thus facilitates a rapid improvement of symptoms. Breast-feeding should continue to be performed in the midst of rehydration, and lactose-containing regular cow's milk formula is recommended for cow's milk-fed patients after rehydration. In mild or severe acute diarrhea, administering probiotics in conjunction with feeding is expected to shorten the diarrheal period.

Figures and Tables

Table 1
The guidelines of clinical management of acute diarrhea
jkma-55-532-i001

From Guarino A, et al. J Pediatr Gastroenterol Nutr 2008;46 Suppl 2:S81-S122 [7].

Table 2
Suitable fluids and foods for acute diarrheal children
jkma-55-532-i002

References

1. American Academy of Pediatrics, Provisional Committee on Quality Improvement, Subcommittee on Acute Gastroenteritis. Practice parameter: the management of acute gastroenteritis in young children. Pediatrics. 1996. 97:424–435.
2. Walker-Smith JA, Sandhu BK, Isolauri E, Banchini G, van Caillie-Bertrand M, Dias JA, Fasano A, Guandalini S, Hoekstra JH, Juntunen M, Kolacek S, Marx D, Micetic-Turk D, Razenberg MC, Szajewska H, Taminiau J, Weizman Z, Zanacca C, Zetterstrom R. European Society of Pediatric Gastroenterology and Nutrition. Guidelines prepared by the ESPGAN Working Group on Acute Diarrhoea. Recommendations for feeding in childhood gastroenteritis. J Pediatr Gastroenterol Nutr. 1997. 24:619–620.
3. Szajewska H, Hoekstra JH, Sandhu B. The Working Group on acute Diarrhoea of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition. Management of acute gastroenteritis in Europe and the impact of the new recommendations: a multicenter study. J Pediatr Gastroenterol Nutr. 2000. 30:522–527.
crossref
4. Brown KH, MacLean WC Jr. Nutritional management of acute diarrhea: an appraisal of the alternatives. Pediatrics. 1984. 73:119–125.
5. Ghadimi H, Kumar S, Abaci F. Endogenous amino acid loss and its significance in infantile diarrhea. Pediatr Res. 1973. 7:161–168.
crossref
6. Williamson RC. Intestinal adaptation (first of two parts). Structural, functional and cytokinetic changes. N Engl J Med. 1978. 298:1393–1402.
7. Guarino A, Albano F, Ashkenazi S, Gendrel D, Hoekstra JH, Shamir R, Szajewska H. Hepatology, and Nutrition. European Society for Paediatric Infectious Diseases. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition/ European Society for Paediatric Infectious Diseases evidencebased guidelines for the management of acute gastroenteritis in children in Europe. J Pediatr Gastroenterol Nutr. 2008. 46:Suppl 2. S81–S122.
8. Hjelt K, Paerregaard A, Petersen W, Christiansen L, Krasilnikoff PA. Rapid versus gradual refeeding in acute gastroenteritis in childhood: energy intake and weight gain. J Pediatr Gastroenterol Nutr. 1989. 8:75–80.
9. Isolauri E, Vesikari T, Saha P, Viander M. Milk versus no milk in rapid refeeding after acute gastroenteritis. J Pediatr Gastroenterol Nutr. 1986. 5:254–261.
crossref
10. Margolis PA, Litteer T, Hare N, Pichichero M. Effects of unrestricted diet on mild infantile diarrhea. A practice-based study. Am J Dis Child. 1990. 144:162–164.
crossref
11. Khin MU, Nyunt-Nyunt-Wai , Myo-Khin , Mu-Mu-Khin , Tin U, Thane-Toe . Effect on clinical outcome of breast feeding during acute diarrhoea. Br Med J (Clin Res Ed). 1985. 290:587–589.
crossref
12. Haffejee IE. Cow's milk-based formula, human milk, and soya feeds in acute infantile diarrhea: a therapeutic trial. J Pediatr Gastroenterol Nutr. 1990. 10:193–198.
crossref
13. Chew F, Penna FJ, Peret Filho LA, Quan C, Lopes MC, Mota JA, Fontaine O. Is dilution of cow's milk formula necessary for dietary management of acute diarrhoea in infants aged less than 6 months? Lancet. 1993. 341:194–197.
crossref
14. Wall CR, Webster J, Quirk P, Robb TA, Cleghorn GJ, Davidson GP, Shepherd RW. The nutritional management of acute diarrhea in young infants: effect of carbohydrate ingested. J Pediatr Gastroenterol Nutr. 1994. 19:170–174.
15. Bhan MK, Arora NK, Khoshoo V, Raj P, Bhatnager S, Sazawal S, Sharma K. Comparison of a lactose-free cereal-based formula and cow's milk in infants and children with acute gastroenteritis. J Pediatr Gastroenterol Nutr. 1988. 7:208–213.
crossref
16. Brown KH, Peerson JM, Fontaine O. Use of nonhuman milks in the dietary management of young children with acute diarrhea: a meta-analysis of clinical trials. Pediatrics. 1994. 93:17–27.
crossref
17. Hwang JB. Clinical approaches for diarrheal disorders in infancy and early childhood. 1999. Daegu: Choongwae.
18. Nazarian LF. A synopsis of the American Academy of Pediatrics' practice parameter on the management of acute gastroenteritis in young children. Pediatr Rev. 1997. 18:221–223.
crossref
19. King CK, Glass R, Bresee JS, Duggan C. Centers for Disease Control and Prevention. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. MMWR Recomm Rep. 2003. 52:1–16.
20. World Health Organization. United Nations Children's Fund. Diarrhoea treatment guidelines including new recommendations for the use of ORS and zinc supplementation for clinic-based healthcare workers. 2005. Arlington (VA): The MOST Project.
21. Wan C, Phillips MR, Dibley MJ, Liu Z. Randomised trial of different rates of feeding in acute diarrhoea. Arch Dis Child. 1999. 81:487–491.
crossref
22. Prasad AS. Zinc deficiency. BMJ. 2003. 326:409–410.
crossref
23. Sachdev HP, Mittal NK, Mittal SK, Yadav HS. A controlled trial on utility of oral zinc supplementation in acute dehydrating diarrhea in infants. J Pediatr Gastroenterol Nutr. 1988. 7:877–881.
crossref
24. Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics. 2008. 121:326–336.
crossref
25. World Health Organization. United Nations Children's Fund. WHO/UNICEF joint statement: clinical management of acute diarrhoea. 2004. New York (NY): United Nations Children's Fund.
26. Boran P, Tokuc G, Vagas E, Oktem S, Gokduman MK. Impact of zinc supplementation in children with acute diarrhoea in Turkey. Arch Dis Child. 2006. 91:296–299.
crossref
27. Food and Agriculture Organization of the United Nations. World Health Organization. Report of the joint FAO/WHO expert consultation on evaluation of health and nutritional properties of probiotics in food including powder milk live lactic acid bacteria. 2001. 1-4 October 2001; Cordoba, Argentina. Geneva: World Health Organization;–.
28. Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, Wagendorp AA, Klijn N, Bindels JG, Welling GW. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr. 2000. 30:61–67.
crossref
29. Szajewska H, Setty M, Mrukowicz J, Guandalini S. Probiotics in gastrointestinal diseases in children: hard and not-so-hard evidence of efficacy. J Pediatr Gastroenterol Nutr. 2006. 42:454–475.
30. Penner R, Fedorak RN, Madsen KL. Probiotics and nutraceuticals: non-medicinal treatments of gastrointestinal diseases. Curr Opin Pharmacol. 2005. 5:596–603.
crossref
31. Huang JS, Bousvaros A, Lee JW, Diaz A, Davidson EJ. Efficacy of probiotic use in acute diarrhea in children: a metaanalysis. Dig Dis Sci. 2002. 47:2625–2634.
32. Szajewska H, Skorka A, Dylag M. Meta-analysis: Saccharomyces boulardii for treating acute diarrhoea in children. Aliment Pharmacol Ther. 2007. 25:257–264.
crossref
33. Sarker SA, Sultana S, Fuchs GJ, Alam NH, Azim T, Brussow H, Hammarstrom L. Lactobacillus paracasei strain ST11 has no effect on rotavirus but ameliorates the outcome of nonrotavirus diarrhea in children from Bangladesh. Pediatrics. 2005. 116:e221–e228.
34. Kayser FH. Safety aspects of enterococci from the medical point of view. Int J Food Microbiol. 2003. 88:255–262.
crossref
35. Egervarn M, Danielsen M, Roos S, Lindmark H, Lindgren S. Antibiotic susceptibility profiles of Lactobacillus reuteri and Lactobacillus fermentum. J Food Prot. 2007. 70:412–418.
crossref
36. Kunz AN, Noel JM, Fairchok MP. Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr. 2004. 38:457–457.
crossref
TOOLS
Similar articles