New therapeutic agents for glycemic control in diabetes mellitus

Hyuk Sang Kwon

doi:10.5124/jkma.2012.55.3.271

Journal List > J Korean Med Assoc > v.55(3) > 1042544

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Kwon: New therapeutic agents for glycemic control in diabetes mellitus

Pharmacotherapeutics

Journal of the Korean Medical Association

Journal of the Korean Medical Association 2012; 55(3): 271-278.

Published online: 9 March 2012

DOI: https://doi.org/10.5124/jkma.2012.55.3.271

New therapeutic agents for glycemic control in diabetes mellitus

Hyuk Sang Kwon, MD

Department of Endocrinology, The Catholic University of Korea College of Medicine, Seoul, Korea.

Corresponding author: Hyuk Sang Kwon, drkwon@catholic.ac.kr

Received 17 February 2012 Accepted 30 February 2012

(open-access):

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A recent report from International Diabetes Federation estimates that 366 million people have diabetes in 2011 and this will have risen to 552 million by 2030. That means one adult in 10 will have diabetes. The prevalence of diabetes among Korean adults aged 20 to 79 years in 2010 was estimated at 9.4% (3.3 million). Diabetes mellitus has thus become a social and economic burden in Korea. However, the percentage of patients to reach their target goal for glycemic control (hemoglobin A1c <7%) is only 40.3%. That indicates further effort for management of diabetic patients is needed. Current diabetic medication includes sulfonylurea, metformin, α-glucosidase inhibitor, thiazolidinedione and dipeptidyl peptidase-4 inhibitor as well as insulin. In this review article, we examine the clinical effects upcoming new diabetes medications and their differences from previous medications.

Keywords: Diabetes mellitus, Therapeutics, Hyperglycemia

Figures and Tables

Table 1

Exenatide and long-acting GLP-1 agonists: similarities and differences

GLP-1, glucagon-like peptide 1; A1C, hemoglobin A1c.

Table 2

Comparison of SGLT1 and SGLT2

SGLT, sodium-glucose co-transporter.

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