Journal List > J Korean Med Assoc > v.50(11) > 1041963

Kho: Reemergence of Malaria in Korea

Abstract

Malaria is one of the most important tropical diseases but also occurring in many temperate regions. After more than 10 years' absence, vivax malaria reemerged in Korea in 1993. The annual occurrence has been increased rapidly, reaching 4,142 cases in 2000. It started to decrease and fell to 826 cases in 2004. Recently, however, the incidence tends to increase. Anopheles sinensis is the major vector of malaria in Korea, and its vectorial capacity is low. This endemic occurred in the northern part of South Korea near the Demilitarized Zone (DMZ). The patients suffered from the typical illness of vivax malaria. It is noteworthy that thrombocytopenia occurred in more than 70% of the patients. It is believed that the malaria is properly diagnosed and treated over the nation along the accumulation of experience. To control the disease, more elaborated programs should be conducted in collaboration with North Korea.

Figures and Tables

Figure 1
Number of indigenous malaria cases in South Korea in 1993~2006 (8).
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Figure 2
Distribution of 278 civilian cases of vivax malaria in 1994~1997 (21).
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References

1. World Health Organization and UNICEF. Section 1: Global malaria situation. In: World malaria report 2005. 2005. Geneva: World Health Organization;5–17.
2. Chun CH, Kim JJ. Malaria in Korea. Korean Med. 1959. 2:63–66.
3. Paik YH. Ministry of Health and Social Affairs. Malaria incidence in the past in Korea. Malaria pre-eradication programme in Korea. Progress Report 1961~1965. 1966. Seoul: Ministry of Health and Social Affairs;1–3.
4. World Health Organization. Synopsis of the world malaria situation. Wkly Epid Rec. 1979. 56:145–149.
5. Chai IH, Lim GI, Yoon SN, Oh WI, Kim SJ, Chai JY. Occurrence of tertian malaria in a male patient who has never been abroad. Korean J Parasitol. 1994. 32:195–200.
crossref
6. Kho WG. Malaria situation in Korea. Korean J Infect Dis. 1997. 29:525–530.
7. Chai JY. Re-emerging Plasmodium vivax malaria in the Republic of Korea. Korean J Parasitol. 1999. 37:129–143.
crossref
8. Korea Center for Disease Control & Prevention. 2007 Manual for malaria control. 2007. Seoul: Korea Center for Disease Control & Prevention;1–132.
9. Krogstad DJ. Malaria as a Reemerging Disease. Epi Rew. 1996. 18:77–89.
crossref
10. Gilles HM, Warrell DA. The malaria parasites. Bruce-Chwatt's essential malariology. 1993. 3rd ed. London: Arnold;13–34.
11. White NJ, Breman JG. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Malaria and babesiosis: Disease caused by red blood cell parasites. Harrison's principles of Internal medicine. 2005. 16th ed. New York: Mc-Graw-Hill;1218–1233.
12. Han ET, Lee DH, Park KD, Seok WS, Kim YS, Tsuboi T, Shin EH, Chai JY. Reemerging vivax malaria: changing patterns of annual incidence and control programs in the Republic of Korea. Korean J Parasitol. 2006. 44:285–294.
crossref
13. Yeom JS, Kim TS, Oh S, Sim JB, Barn JS, Kim HJ, Kim YA, Ahn SY, Shin MY, Yoo JA, Park JW. Plasmodium vivax malaria in the Republic of Korea during 2004~2005: changing patterns of infection. Am J Trop Med Hyg. 2007. 76:865–868.
crossref
14. Ree HI. Unstable vivax malaria in Korea. Korean J Parasitol. 2000. 38:119–138.
crossref
15. Kho WG, Park YH, Chung JY, Kim JP, Hong ST, Lee WJ, Kim TS, Lee JS. Two new genotypes of Plasmodium vivax circumsporozoite protein found in the Republic of Korea. Korean J Parasitol. 1999. 37:265–270.
crossref
16. Han ET, Park JH, Shin EH, Choi MH, Oh MD, Chai JY. Apical membrane antigen-1 (AMA-1) gene sequences of reemerging Plasmodium vivax in South Korea. Korean J Parasitol. 2002. 40:157–162.
crossref
17. Lee HW, Shin EH, Cho SH, Lee HI, Kim CL, Lee WG, Moon SU, Lee JS, Lee WJ, Kim TS. Detection of vivax malaria sporozoites naturally infected in Anopheline mosquitoes from endemic areas of northern parts of Gyeonggi-do (Province) in Korea. Korean J Parasitol. 2002. 40:75–81.
crossref
18. Shin EH, Kim TS, Lee HW, Lee JS, Lee WJ. Vector competence of Anopheles lesteri Baisas and Hu (Diptera: Culicidae) to Plasmodium vivax in Korea. Korean J Parasitol. 2002. 40:41–44.
crossref
19. Cho SY, Kong Y, Park SM, Lee JS, Lim YA, Chae SL, Kho WG, Shim JC, Shin HK. Two vivax malaria cases detected in Korea. Korean J Parasitol. 1994. 32:281–284.
crossref
20. Ree HI. Can Malaria be Endemic in South Korea? Korean J Infect Dis. 1998. 30:397–400.
21. Kho WG, Jang JY, Hong ST, Lee HW, Lee WJ, Lee JS. Border malaria characters of reemerging vivax malaria in the Republic of Korea. Korean J Parasitol. 1999. 37:71–76.
crossref
22. Regional Office of South-East Asia. Epidemiological situation 2005. World Health Organization. Malaria Situation in SEAR Countries: DPR Korea;(http://www.searo.who.int/EN/Section10/Section21/Section340_4020.htm).
23. World Health Organization. 2007 Emergency and Humanitarian Action. Country Report: DPR Korea. 2007. Geneva: World Health Organization;33–38.
24. Cho YH, Kwon SY, Seo DH, Kim SI. Transfusion-Transmitted Malaria in Korea-10 cases during 1997~2001. Korean J Blood Transfus. 2001. 12:263–270.
25. Seo DH, Cho YH, Yeo WH, Hwang BK, Jung HJ, Hwang YS, Kim SI. Analysis of Blood Donation History of Korean Malaria Patients. Korean J Clin Pathol. 1999. 19:569–571.
26. Choe GS, Kim KJ, Oh SH, Lee WS, Lee H. A Case of Congenital Malaria due to Plasmodium vivax. Korean J Infect Dis. 2001. 33:223–226.
27. Lee EJ, Chang HH, Lee CG, Cho CR. A Case of Congenital Malaria. J Korean Pediatr Soc. 2003. 46:821–825.
28. Kim CS, Shin DC, Yong TS, Oh DK, Kim RK, Park KH, Suh I. Chemoprophylaxis and the epidemiological characteristics of re-emergent P. vivax malaria in the Republic of Korea. Bull World Health Organ. 2006. 84:827–834.
29. Yeom JS, Ryu SH, Oh S, Choi DH, Song KJ, Oh YH, Lee JH, Kim YA, Ahn SY, Yang HY, Cha JE, Park JW. Evaluation of anti-malarial effects of mass chemoprophylaxis in the Republic of Korea army. J Korean Med Sci. 2005. 20:707–712.
crossref
30. Koo KB, Cho NH, Kim SH, Won YJ, Cho HS. The Clinical Analysis of 79 Cases of Indigenous Malaria in Myongji Hospital during 4 Years. J Korean Acad Fam Med. 2004. 25:403–410.
31. Lim CS, Kim YK, Lee KN, Kim KH, Kim HS, Lim HW, Kim BS. Hematologic Findings of Reappeared Plasmodium vivax in Korea. Korean J Clin Pathol. 1996. 16:836–843.
32. Lim HW, Seo JY, Ahn YS, Oh SY, Kim DR, Lim CS, Kang MW. Epidemiologic and clinicla Analysis of 87 Indigenous Malaria in Korean Soldiers in 1995. Korean J Infect Dis. 1996. 28:219–224.
33. Lim HS, Kim HS. Evaluation of diagnostic methods of reemerging malaria in Korean patients. Yonsei Med J. 2001. 42:84–90.
crossref
34. Lim CS, Ma KR, Kim YK, Lee KN, Kim KH, Kim MJ, Kho WK, Kim DS. The Results of Antimalarial Treatment of Resurgent Vivax Malaria in Korea. Korean J Infect Dis. 1997. 29:413–416.
35. Lee HY, Han JY, Lee KD, Park WB, Kim SH, Kang CI, Moon JJ, Oh MD, Choe KW. A Case of Tertian Malaria which Recurred Three Times Despite Standard Chloroquine primaquine Therapy. Korean J Infect Dis. 2002. 34:396–400.
36. Shin DH, Kim KS, Kim YJ, Lee SH, Kim SJ, Cho CK, Shin JH, Ryang DW, Lee JH. A Case of Spontaneous Splenic Rupture in Vivax Malaria. Korean J Infect Dis. 1999. 31:176–179.
37. Kim SM, Kim KB, Jung HJ, Kim WJ, Kim MJ, Park SC. Retinal Hemorrhage in an Adult with P. vivax Malaria. Korean J Infect Dis. 1997. 29:323–326.
38. Nishiura H, Lee HW, Cho SH, Lee WG, In TS, Moon SU, Chung GT, Kim TS. Estimates of short- and long-term incubation periods of Plasmodium vivax malaria in the Republic of Korea. Trans R Soc Trop Med Hyg. 2007. 101:338–343.
crossref
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