Recent Concepts of Human Papillomavirus Vaccine

Woong Shick Ahn

doi:10.5124/jkma.2007.50.9.778

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Ahn: Recent Concepts of Human Papillomavirus Vaccine

Focused Issue of This Month

Cervical Cancer

Journal of the Korean Medical Association

Journal of the Korean Medical Association 2007; 50(9): 778-784.

Published online: 30 September 2007

DOI: https://doi.org/10.5124/jkma.2007.50.9.778

Recent Concepts of Human Papillomavirus Vaccine

Woong Shick Ahn, MD

Department of Obstetrics and Gynecology, The Catholic University of Korea College of Medicine, Korea. ahnws@catholic.ac.kr

Abstract

Two prophylactic human papillomavirus (HPV) vaccines against types 6, 11, 16 and 18 have shown great promise in clinical trials with recent results demonstrating 100% efficacy against persistent HPV infection and development of cervical intraepithelial neoplasia up to five years of follow-up. Published data from the phase-IIb and III trials thus far indicate that the prophylactic HPV L1 virus-like particle vaccine is safe and well-tolerated. It offers HPV-naive women a very high level of protection against HPV persistent infection and cervical intraepithelial lesions associated with the types included in the vaccine. HPV vaccination should be also offered to girls before onset of sexual activity. But there are still questions about several issues of HPV prophylactic vaccination. Prolonged clinical trials should be performed for demonstration of these remaining questions. Finally, prophylactic vaccines against HPV will certainly reduce the incidence of the risk of developing cervical cancer.

Keywords: Human papilloma virus, Prophylactic vaccine, Therapeutic vaccine

Figures and Tables

Table 1

Study characteristics and main results reported by three randomised placebo-controlled phase-IIb HPV vaccination trials

ATP; according-to-protocol analysis, CI; 95% confidence interval, GMT; geometric mean titre of antibodies, ITT; intention-to-treat analysis, VLP; virus like particles

^*No cases in vaccinated or placebo group

Table 2

Phase-III vaccination trials, currently being conducted or planned (adapted from Cohen (2005))

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