Journal List > Korean J Hepatobiliary Pancreat Surg > v.16(2) > 1040571

Jung, Park, and Youn: Huge subcapsular hematoma caused by intrahepatic sarcomatoid cholangiocarcinoma

Abstract

Intrahepatic sarcomatoid cholangiocarcinomais is a very rare disease with a poor prognosis due to its biologically aggressive tumor behavior. We report a patient who presented with subcapsular hemorrhage and a rapidly growing liver mass. A 57 year-old man was admitted with severe abdominal pain. CT and MRI images showed the presence of a 10 cm-sized subcapsular hemorrhage connected with a multi-lobulated mass with hemorrhage and necrotic foci in the right liver. The patients underwent right hemihepatectomy with caudate lobectomy and lymphadenectomy. The operation findings revealed metastatic nodules to the diaphragm and omentum. Detailed histopathological analysis through immunohistochemistry confirmed the diagnosis of sarcomatoid cholangiocarcinoma with a poorly undifferentiated sarcomatous component. The patient underwent chemotherapy. To date, the patient is doing well for 8 months after initial diagnosis.

References

1. Haratake J, Horie A. An immunohistochemical study of sarcomatoid liver carcinomas. Cancer. 1991. 68:93–97.
2. Kakizoe S, Kojiro M, Nakashima T. Hepatocellular carcinoma with sarcomatous change. Clinicopathologic and immunohistochemical studies of 14 autopsy cases. Cancer. 1987. 59:310–316.
3. Nakajima T, Tajima Y, Sugano I, et al. Intrahepatic cholangiocarcinoma with sarcomatous change. Clinicopathologic and immunohistochemical evaluation of seven cases. Cancer. 1993. 72:1872–1877.
4. Kojiro M, Sugihara S, Kakizoe S, et al. Hepatocellular carcinoma with sarcomatous change: a special reference to the relationship with anticancer therapy. Cancer Chemother Pharmacol. 1989. 23:Suppl. S4–S8.
5. Kubota K, Kakuta Y, Kawamura S, et al. Undifferentiated spindle-cell carcinoma of the gallbladder: an immunohistochemical study. J Hepatobiliary Pancreat Surg. 2006. 13:468–471.
6. Diebold-Berger S, Vaiton JC, Pache JC, et al. Undifferentiated carcinoma of the gallbladder. Report of a case with immunohistochemical findings. Arch Pathol Lab Med. 1995. 119:279–282.
7. Yoo HJ, Yun BR, Kwon JH, et al. Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells. Exp Mol Med. 2009. 41:102–115.
8. Shimada M, Takenaka K, Rikimaru T, et al. Characteristics of sarcomatous cholangiocarcinoma of the liver. Hepatogastroenterology. 2000. 47:956–961.
9. Kaibori M, Kawaguchi Y, Yokoigawa N, et al. Intrahepatic sarcomatoid cholangiocarcinoma. J Gastroenterol. 2003. 38:1097–1101.
10. Tsou YK, Wu RC, Hung CF, et al. Intrahepatic sarcomatoid cholangiocarcinoma: clinical analysis of seven cases during a 15-year period. Chang Gung Med J. 2008. 31:599–605.
11. Malhotra S, Wood J, Mansy T, et al. Intrahepatic sarcomatoid cholangiocarcinoma. J Oncol. 2010. 70:701476.
TOOLS
Similar articles