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Lee, Lee, Nam, Roh, Yoon, Lim, Cho, Kim, Lee, and Yoo: Epidemiologic Features of Parainfluenza Virus Type 1, 2 and 3 Infection in Seoul and a Neighboring Area, 2008-2011
Original Article
Korean Journal of Clinical Microbiology

Korean Journal of Clinical Microbiology 2012; 15(2): 54-59.

Published online: 20 June 2012

DOI: https://doi.org/10.5145/KJCM.2012.15.2.54

Epidemiologic Features of Parainfluenza Virus Type 1, 2 and 3 Infection in Seoul and a Neighboring Area, 2008-2011

Hyejin Lee1, Chang Kyu Lee1, Myung-Hyun Nam1, Kyoung Ho Roh1, Soo-Young Yoon1, Chae Seung Lim1, Yunjung Cho1, Young Kee Kim1, Kap No Lee1, Young Yoo2

1Department of Laboratory Medicine, Korea University College of Medicine, Seoul, Korea.

2Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.

Correspondence: Chang Kyu Lee, Department of Laboratory Medicine, Korea University College of Medicine, 73 Inchon-ro, Seongbuk-gu, Seoul 136-705, Korea. (Tel) 82-2-920-5381, (Fax) 82-2-920-5538, cklee@korea.ac.kr

Received 14 September 2011       Revised 7 November 2011       Accepted 7 November 2011

Copyright © 2012 The Korean Society of Clinical Microbiology

Abstract

Background

Parainfluenza virus (PIV) is a significant cause of acute respiratory infections. Epidemiological information on PIV infection could be very helpful for patient management. The aim of this study was to investigate the epidemiology of PIV infection in Seoul and a neighboring area with regard to PIV type.

Methods

The diagnosis of PIV infection was made by virus isolation. The R-mix Too cell system (Diagnostic Hybrids, Inc., Athens, OH, USA) and D3 Ultra DFA Respiratory Virus Screening & ID kits (Diagnostic Hybrids, Inc.) were used for virus culture and identification. The medical records of patients with positive virus cultures were reviewed retrospectively.

Results

Seven hundred and ten PIV viruses (5.6%) were isolated from 12,723 specimens. The number of subjects with PIV type III, I and II was 357, 304 and 49, respectively. PIV infection showed a peak incidence in the first year of life regardless of subtypes. The most common diagnosis among all PIV subtypes was pneumonia. Lower respiratory tract infections constituted the majority (76.3%) of PIV infections. The most common diagnosis of PIV type I and II was croup and that of PIV type III was pneumonia. A difference in seasonal variation between subtypes was observed. PIV I (62.2%) was mainly isolated from July to September while PIV type III (86.8%) was isolated from April to July.

Conclusion

Lower respiratory infection was most commonly found in hospitalized patients with PIV infection. Clinical features of PIV infection were similar those seen in Western PIV reports, with the exception of the seasonal outbreak pattern.

Keywords: Epidermiology, Parainfluenza virus, Respiratory tract infection

Figures and Tables

Fig. 1
Counts of parainfluenza virus -1, -2, and -3 isolates by month of year for 2008-2011.
kjcm-15-54-g001
Fig. 2
Virus type (number of isolates according to age, years). Abbreviation: See Table 1.
kjcm-15-54-g002
Table 1
Prevalence of type of PIV according to age
kjcm-15-54-i001

Abbreviation: PIV, parainfluenza virus.

Table 2
Prevalence of type of PIV according to clinical diagnosis in patient
kjcm-15-54-i002

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