Fungemia due to Exophiala dermatitidis

Eun Sun Jeong; Jong Hee Shin; Myung Geun Shin; Soon Pal Suh; Dong Wook Ryang

doi:10.5145/KJCM.2010.13.3.135

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Jeong, Shin, Shin, Suh, and Ryang: Fungemia due to Exophiala dermatitidis

Original Article

Korean J Clin Microbiol 2010;13(3):135-139.

Published online: 21 September 2010

DOI: https://doi.org/10.5145/KJCM.2010.13.3.135

Fungemia due to Exophiala dermatitidis

Eun Sun Jeong, Jong Hee Shin, Myung Geun Shin, Soon Pal Suh, Dong Wook Ryang

Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea

Correspondence: Jong Hee Shin, Department of Laboratory Medicine, Chonnam National University Medical School, 671 Jebong-ro, Dong-gu, Gwangju 501-757, Korea. (Tel) 82-62-220-5342, (Fax) 82-62-224-2518, (E-mail) shinjh@chonnam.ac.kr

Received 12 January 2010 Revised 13 July 2010 Accepted 20 August 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a rare case of fungemia due to Exophiala (Wangiella) dermatitidis in a 4-month-old female infant who was admitted to an intensive care unit with sudden infant death syndrome (SIDS). E. dermatiti-diswas repeatedly isolated from blood cultures (on the 28th and 32nd day of hospitalization) of the patient, who died on the 44th day of hospitalization. The fungus was identified by its morphological characteristics and DNA sequencing of both the D1/D2 domain and the ITS region of rDNA. To our knowledge, this is the first reported case of E. dermatitidis fungemia in Korea.

Keywords: Exophiala (Wangiella) dermatitidis, Fungemia, ITS, Sequencing

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Fig. 1.

Two weeks after incubation at 30°C on the potato dextrose agar, the colonies appeared as black, reverse black, wet, and mucoid.

Fig. 2.

Microscopically, septate, and pale olivaceous hyphae and black yeast synanarmorphs were found. Conidiogenous cells were cylindrical, with rounded apeces producing one-celled conidia. Round to ovoid, pale brown conidia accumulated in balls or slipped down the side of conidiophores (Lactophenol cotton blue stain, ×400).

Fig. 3.

A pyelogenetic tree of Exophiala and neighboring species, constructed by using neighbor-joining algorithm.

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