Journal List > Korean J Clin Microbiol > v.13(3) > 1038191

Korean J Clin Microbiol. 2010 Sep;13(3):125-127. Korean.
Published online September 30, 2010.  https://doi.org/10.5145/KJCM.2010.13.3.125
Copyright © 2010 The Korean Society of Clinical Microbiology
Two Cases of Clostridium citroniae Bacteremia in Cancer Patients
Yangsoon Lee, Eun-Mi Koh, Myungsook Kim, Dongeun Yong, Seok Hoon Jeong, Kyungwon Lee, and Yunsop Chong
Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea.

Correspondence: Kyungwon Lee, Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, 250 Seongsan-ro, Seodaemun-gu, Seoul 120-752, Korea. (Tel) 82-2-2228-2446, (Fax) 82-2-313-0908, Email: leekcp@yuhs.ac
Received March 02, 2010; Revised June 23, 2010; Accepted July 20, 2010.

Abstract

Clostridium citroniae is a novel species reclassified from C. clostridioforme. Clostridium species are obligate anaerobes and spore-forming gram-positive rods. However, C. citroniae stains gram negative and does not consistently produce spores, making it difficult to identify. We isolated C. citroniae from the blood and peritoneal fluid of one patient, and from the blood of another patient, both of whom were undergoing cancer chemotherapy.

Keywords: Clostridium citroniae; Bacteremia

Tables


Table 1
Biochemical characteristics of C. citroniae clinical isolates
Click for larger image

References
1. Murry PR, Baron EJ, et al., editors. Manual of Clinical Microbiology. 9th ed. American Society for Microbiology; 2007. pp. 889-910.
2. Finegold SM, Song Y, Liu C, Hecht DW, Summanen P, Könönen E, et al. Clostridium clostridioforme: a mixture of three clinically important species. Eur J Clin Microbiol Infect Dis 2005;24:319–324.
3. Warren YA, Tyrrell KL, Citron DM, Goldstein EJ. Clostridium aldenense sp. nov. and Clostridium citroniae sp. nov. isolated from human clinical infections. J Clin Microbiol 2006;44:2416–2422.
4. Bodey GP, Rodriguez S, Fainstein V, Elting LS. Clostridial bacteremia in cancer patients. A 12-year experience. Cancer 1991;67:1928–1942.
5. Summanen P, Baron EJ, Citron DM, et al. In: Wadsworth anaerobic bacteriology manual. 5th ed. Star Publishing; 1993.
6. Elsayed S, Zhang K. Human infection caused by Clostridium hathewayi. Emerg Infect Dis 2004;10:1950–1952.
7. Song Y, Liu C, Molitoris DR, Tomzynski TJ, Lawson PA, Collins MD, et al. Clostridium bolteae sp. nov., isolated from human sources. Syst Appl Microbiol 2003;26:84–89.
8. Woo PC, Lau SK, Woo GK, Fung AM, Yiu VP, Yuen KY. Bacteremia due to Clostridium hathewayi in a patient with acute appendicitis. J Clin Microbiol 2004;42:5947–5949.
9. Chen YM, Lee HC, Chang CM, Chuang YC, Ko WC. Clostridium bacteremia: emphasis on the poor prognosis in cirrhotic patients. J Microbiol Immunol Infect 2001;34:113–118.