Osteoporotic Spinal Compression Fracture and Degree of Vitamin D Deficiency

Hong-Sik Kim; Youn-Ho Choi; Ki-Chul Park; Ye-Soo Park

doi:10.12671/jkfs.2013.26.1.27

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Kim, Choi, Park, and Park: Osteoporotic Spinal Compression Fracture and Degree of Vitamin D Deficiency

Original Article

Journal of the Korean Fracture Society

Journal of the Korean Fracture Society 2013; 26(1): 27-31.

Published online: 17 January 2013

DOI: https://doi.org/10.12671/jkfs.2013.26.1.27

Osteoporotic Spinal Compression Fracture and Degree of Vitamin D Deficiency

Hong-Sik Kim, M.D., Youn-Ho Choi, M.D., Ki-Chul Park, M.D., Ye-Soo Park, M.D.

Department of Orthopaedic Surgery, Hanyang University Guri Hospital, Hanyang University College of Medicine, Seoul, Korea.

Address reprint requests to: Ye-Soo Park, M.D. Department of Orthopaedic Surgery, Hanyang University Guri Hospital, 153, Gyeongchun-ro, Guri 471-701, Korea. Tel: 82-31-560-2316, Fax: 82-31-557-8781, hyparkys@hanyang.ac.kr

Received 27 June 2012 Revised 20 July 2012 Accepted 26 October 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

The aim of the present study was to evaluate the degree of serum vitamin D deficiency in patients with osteoporotic spinal compression fracture and correlation of serum vitamin D level with several variables.

Materials and Methods

The medical records of 134 patients with osteoporotic spinal compression fracture, diagnosed at our hospital between October 2008 and June 2011, were reviewed. Serum 25(OH)vitamin D₃ was used to evaluate the status of vitamin D level. Serum 25(OH)vitamin D₃ level was compared and analyzed according to sex, the number of fractured vertebral body, living environment, and the season of injury. The correlation between vitamin D level and age, bone mineral density, and bone turnover marker were evaluated.

Results

In the serum 25(OH)vitamin D₃, 87 patients (65%) associated with osteoporotic spinal compression fracture had an insufficient level. Vitamin D level was the lowest in winter, the highest in summer, and significantly higher in the living home than nursing home. Vitamin D level was negatively correlated with age (r=-0.201, p=0.02) and positively correlated with bone mineral density (r=0.217, p=0.012).

Conclusion

Evaluation of vitamin D level in osteoporotic vertebral compression fracture patients may be helpful in planning the treatment of the patients. For insufficient vitamin D level, the adequate sun exposure and supplement of vitamin D may be used.

Keywords: Osteoporosis, Compression fracture, Vitamin D

Figures and Tables

Fig. 1

Correlation between serum 25(OH)vitamin D₃, bone mineral density (BMD) and age.

(A) Serum 25(OH)vitamin D₃ levels were positively correlated with BMD (r=0.217, p=0.012).

(B) Serum 25(OH)vitamin D₃ levels were negatively correlated with age (r=-0.201, p=0.02).

Table 1

Demographic Information and Clinical Data of the Patients (n=134)

Values are presented as mean±standard deviation or number.

BMD: Bone mineral density.

Table 2

BMD and 25(OH)vitamin D₃ According to the Number of Fractured Vertebral Body

BMD: Bone mineral density.

Table 3

Correlations between 25(OH)vitamin D₃ and Other Variables

BMD: Bone mineral density.

Table 4

Comparison of Variables between Insufficient and Normal Group in 25(OH)vitamin D₃ Level

BMD: Bone mineral density.

References

1. Bischoff-Ferrari HA, Can U, Staehelin HB, et al. Severe vitamin D deficiency in Swiss hip fracture patients. Bone. 2008. 42:597–602.

2. Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006. 84:18–28.

3. Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC. Benefit-risk assessment of vitamin D supplementation. Osteoporos Int. 2010. 21:1121–1132.

4. Bouillon R, Bischoff-Ferrari H, Willett W. Vitamin D and health: perspectives from mice and man. J Bone Miner Res. 2008. 23:974–979.

5. Chesnut CH 3rd. Osteoporosis, an underdiagnosed disease. JAMA. 2001. 286:2865–2866.

6. Eisman JA, Kelly PJ, Morrison NA, et al. Peak bone mass and osteoporosis prevention. Osteoporos Int. 1993. 3:Suppl 1. 56–60.

7. Fujiwara S. Epidemiology of osteoporosis and fracture. Clin Calcium. 2004. 14:13–18.

8. Garnero P, Gineyts E, Riou JP, Delmas PD. Assessment of bone resorption with a new marker of collagen degradation in patients with metabolic bone disease. J Clin Endocrinol Metab. 1994. 79:780–785.

9. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004. 80:1678S–1688S.

10. Holick MF. Vitamin D deficiency. N Engl J Med. 2007. 357:266–281.

11. Lee WS, Lee SH, Han SB, Jeong WK, Park SY. Vitamin D inadequacy in patients with osteoporotic hip fractures. Korean J Bone Metab. 2011. 18:9–14.

12. Lim SK, Kung AW, Sompongse S, Soontrapa S, Tsai KS. Vitamin D inadequacy in postmenopausal women in Eastern Asia. Curr Med Res Opin. 2008. 24:99–106.

13. Lips P, Bouillon R, van Schoor NM, et al. Reducing fracture risk with calcium and vitamin D. Clin Endocrinol (Oxf). 2010. 73:277–285.

14. Moniz C, Dew T, Dixon T. Prevalence of vitamin D inadequacy in osteoporotic hip fracture patients in London. Curr Med Res Opin. 2005. 21:1891–1894.

15. Visser M, Deeg DJ, Lips P. Longitudinal Aging Study Amsterdam. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia). J Clin Endocrinol Metab. 2003. 88:5766–5772.

16. Yamaguchi K, Masuhara K, Yamasaki S, Nakai T, Fuji T. Predictive value of a preoperative biochemical bone marker in relation to bone remodeling after cementless total hip arthroplasty. J Clin Densitom. 2003. 6:259–265.

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