This article has been corrected. See "Erratum: Intermittent Parathyroid Hormone Treatment for Stimulation of Callus Formation in Elderly Patients" in Volume 26 on page 170.
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Abstract
Purpose
The purpose of this study was to evaluate the effect of parathyroid hormone (PTH) on fracture healing in elderly patients.
Materials and Methods
We analyzed the radiologic results in 14 patients. Group I (n=7) was administrated intermittent PTH after surgical treatment and group II (n=7) was treated only with surgery. We checked the time of initial callus formation, bridging callus formation, and bone union through periodic follow-up radiographs by a radiologist who did not know the patient's information.
Results
The mean time to initial callus formation was 6 weeks for group I, compared with 6.7 weeks for group II. The mean time to bridging callus formation was 15.9 weeks for group I, compared with 23.0 weeks for group II. The mean time to bone union was 28.7 weeks for group I, compared with 41.9 weeks for group II. The difference in the cumulative detection rate (CDR) of the initial callus formation of group I and II was not statistically significant (p=0.793). However, the CDR of the bridging callus formation and bone union for group I were higher than those of group II (p=0.008, p=0.001, respectively).
Figures and Tables
Fig. 1
Comparison of cumulative detection rate curves on a time-dependent graph for the bridging callus formation in group I and II. Group I was statistically superior to group II (p=0.008). PTH: Parathyroid hormone.
Fig. 2
Comparison of cumulative detection rate curves on a time-dependent graph for the bone union in group I and II. Group I was statistically superior to group II (p=0.001). PTH: Parathyroid hormone.
Fig. 3
Comparison of cumulative detection rate (CDR) curves on a time-dependent graph for the initial callus formation in group I and II. The time represents the period beginning at the operation and is designated along the X-axis whenever positive findings were found for each curve. The difference in the CDR of group I and II was not statistically significant (p=0.793). PTH: Parathyroid hormone.
References
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