Fat embolism is a rare complication of multiple long bone fracture or extensive soft tissue injury. The pathogenesis of fat embolism has been poorly understood and definite pathogenesis and treatment were not fully established. Respiratory failure associated with fat embolism is a major cause of death, but is usually self-limited, and is responsive to intensive treatment. We have experienced fat embolism in cancellous bone fracture which occurred in spine, distal radius and talus. Patient's fractures were treated with conservative management. The patient was recovered from fat embolism with supportive treatment.