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Lee, Kang, Lee, Nam, Yoo, and Han: Apoptosis and Cell Proliferation in Gastric Adenoma and Adenocarcinoma
Original Article

Journal of the Korean Gastric Cancer Association 2006; 6(2): 91-96.

Published online: 13 March 2017

DOI: https://doi.org/10.5230/jkgca.2006.6.2.91

Apoptosis and Cell Proliferation in Gastric Adenoma and Adenocarcinoma

Dong Soo Lee, Sang Bum Kang, Seung Woo Lee, Soon Woo Nam, Young Kyung Yoo1, Sok Won Han

Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Corresponding author (endoscope@hanmail.net)

Copyrights © 2006 by The Korean Gastric Cancer Association

Abstract

Purpose

Cancer is a genetic disease caused by alterations in key regulators of cell growth and cell turnover. We investigated apoptotic cell death and cell proliferation in gastric adenomas and adenocarcinomas.

Materials and Methods

The TdT-mediated dUTP-biotin nick end labelling (TUNEL) method and immunohistochemistry for Ki-67 were performed, using paraffin-embedded tissues of 41 gastric adenomas and 100 gastric adenocarcinomas. These results were compared with histopathologic parameters.

Results

The Ki-67 labelling index was higher in adenocarcinomas than in adenomas and the apoptotic index was higher in adenomas than in adenocarcinomas. There were no significant difference between the apoptotic index/Ki-67 labelling index and clinicopathological parameters.

Conclusion

We propose that cell proliferation is more closely associated with gastric adenocarcinomas than apoptosis is, but that neither has any clinical significance as a prognostic factor in gastric adenocarcinomas.

Keywords: Apoptosis, Cell proliferation, Gastric adenocarcionoma, Gastric adenoma

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