A 45-year-old man was found to have advanced cancer of the gastric antrum and lower body with multiple liver metastases. A palliative subtotal gastrectomy was performed, and multiple hepatic lesions were treated by hepatic arterial infusion therapy with floxuridine (FUdR) 3 weeks after the operation. This therapy was given for 14 days every 3 weeks. He received 4 cycles of the therapy. A systemic combination of chemotherapy with 5-FU and cisplatin was also perfomed. These two courses of intraarterial infusion therapy produced marked regression of liver metastases and necrosis. The effect was, thus, rated as a partial response. However, after the 4th course of the therapy, the patient dropped out for personal reasons. A brain metastasis was found 4 months later, and this intraarterial infusion therapy could no longer be performed. This case indicates that intraarterial infusion chemotherapy with FUdR may be useful in treating multiple liver metastases from gastric cancer.