Validation and Controversy of Sentinel Node Biopsy for Breast Cancer

Kazuyoshi Motomura; Chiyomi Egawa; Yoshifumi Komoike; Tatsuki Kataoka; Sachiko Nagumo; Hiroki Koyama; Hideo Inaji

doi:10.4048/jbc.2006.9.2.74

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Motomura, Egawa, Komoike, Kataoka, Nagumo, Koyama, and Inaji: Validation and Controversy of Sentinel Node Biopsy for Breast Cancer

Review Article

Journal of Breast Cancer

Journal of Breast Cancer 2006; 9(2): 74-83.

Published online: 30 June 2006

DOI: https://doi.org/10.4048/jbc.2006.9.2.74

Validation and Controversy of Sentinel Node Biopsy for Breast Cancer

Kazuyoshi Motomura, Chiyomi Egawa, Yoshifumi Komoike, Tatsuki Kataoka¹, Sachiko Nagumo², Hiroki Koyama, Hideo Inaji

Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.

¹Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.

²Department of Cytology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.

Correspondence: Kazuyoshi Motomura. Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka 537-8511, Japan. Phone: +81-6-6972-1181, Fax: +81-6-6981-8055, motomurak@hotmail.com

Abstract

Sentinel node biopsy has become a promising technique to accurately stage breast cancer patients with less morbidity than axillary lymph node dissection. However, many problems remain, such as the ideal injection technique, agents, and histological detection of sentinel node metastases, and they must be addressed before sentinel node biopsy becomes the standard for the care of breast cancer patients. The results of ongoing large clinical trials will provide clues to solve these problems. The purpose of this article is to review the current literature regarding confirmation of the sentinel node hypothesis and the controversy of sentinel node biopsy.

Keywords: sentinel node, breast cancer, sentinel node biopsy

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