Prediction of additional axillary metastasis of breast cancer with positive sentinel lymph nodes

Seung Pil Jung; Jeoung Won Bae; Sang Uk Woo; Jae Bok Lee; Gil Soo Son; Yang Sok Chae; Kyu Ran Jo; Bum Hwan Goo

doi:10.4048/jbc.2006.9.4.337

Journal List > J Breast Cancer > v.9(4) > 1036803

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Jung, Bae, Woo, Lee, Son, Chae, Jo, and Goo: Prediction of additional axillary metastasis of breast cancer with positive sentinel lymph nodes

Case Report

Journal of Breast Cancer

Journal of Breast Cancer 2006; 9(4): 337-342.

Published online: 31 December 2006

DOI: https://doi.org/10.4048/jbc.2006.9.4.337

Prediction of additional axillary metastasis of breast cancer with positive sentinel lymph nodes

Seung Pil Jung, Jeoung Won Bae, Sang Uk Woo, Jae Bok Lee, Gil Soo Son, Yang Sok Chae¹, Kyu Ran Jo², Bum Hwan Goo¹

Department of Sugery, Korea University, College of Medicine, Seoul, Korea.

¹Department of pathology, Korea University, College of Medicine, Seoul, Korea.

²Department of Radiology, Medicine, Korea University, College of Medicine, Seoul, Korea.

kujwbae@korea.ac.kr

Received 17 November 2006 Accepted 13 December 2006

Abstract

Prediction of Additional Axillary Metastasis of Breast Cancer with Positive Sentinel Lymph Nodes.

Purpose

Axillary lymph node dissection in breast cancer patients with positive sentinel lymph node (SLN) is accepted as a routine procedure. In a significant proportion of women with breast cancer, the SLN is the sole site of regional metastasis. These patients would not be expected to benefit from complete lymph node dissection. The purpose of this study is to determine which factors are associated with additional positive lymph nodes in the axilla of patients who have positive sentinel lymph nodes.

Methods

Between September 2001 and May 2005, we examined 135 cases where the patients underwent a breast conserving operation and a SLN biopsy. There were 34 patients with positive SLN. Univariate analysis was used to identify the clinicopathologic features in the SLN positive patients that can predict metastasis in the nonsentinel lymph nodes (NSLNs).

Results

Fifteen patients (44.1%) had metastasis in the NSLNs. There were significant differences in the location of tumors (p=0.018), the nodal status of each patient (p=0.001) and c-erbB2 protein expression (p=0.017) in NSLN metastasis as determined by univariate analysis.

Conclusion

The location of the breast cancer, nodal status and c-erbB2 expression are of predictive value for NSLN involvement. We suggest that a full axillary lymph node dissection may be considered as a sparing treatment in these situations.

Keywords: Breast cancer, nonsentinel lymph node, axillary lymph node dissection

Figures and Tables

Table 1

Axillary lymph nodes dissection after sentinel lymph nodesopsy Lymp

SLNs = sentinel lymph nodes; NSLNs = non sentinel lymph nodes.

Table 2

Characteristics of sentinel lymph node positive patients

LNs = lymph nodes; SLNs = sentinel lymph nodes; NSLNs = non sentinel lymph nodes.

Table 3

Clinicopathologic characteristics of patients according to the age group

UOQ = upper outer quadrant; UIQ = upper inner quadrant; LIQ = lower inner quadrant; LOQ = lower outer quadrant; LVI = Lymphovascular invasion; SLNs = sentinel lymph nodes.

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