Relationship of Bone mineral density and the risk of breast cancer in Korean postmenopausal women

Hee Jeong Kim; Jung man Nam-Gung; Jung Min Koh; Jung sun Lee; Soo jeong Hong; Beom Seok Kwak; Bo kyung Gu; Mi Ae Jang; Byung Ho Son; Sei Hyun Ahn

doi:10.4048/jbc.2006.9.4.330

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Kim, Nam-Gung, Koh, Lee, Hong, Kwak, Gu, Jang, Son, and Ahn: Relationship of Bone mineral density and the risk of breast cancer in Korean postmenopausal women

Original Article

Journal of Breast Cancer

Journal of Breast Cancer 2006; 9(4): 330-336.

Published online: 31 December 2006

DOI: https://doi.org/10.4048/jbc.2006.9.4.330

Relationship of Bone mineral density and the risk of breast cancer in Korean postmenopausal women

Hee Jeong Kim, Jung man Nam-Gung, Jung Min Koh¹, Jung sun Lee, Soo jeong Hong, Beom Seok Kwak², Bo kyung Gu, Mi Ae Jang, Byung Ho Son, Sei Hyun Ahn

Department of surgery, College of Medicine, University of Ulsan, Asan Medical center, Seoul, Korea.

¹Division of endocrinology and Metabolism, College of Medicine, University of Ulsan, Asan Medical center, Seoul, Korea.

²Department of surgery, Dongguk University international Hospital, Il San, Korea.

ahnsh@amc.seoul.k

Received 21 September 2006 Accepted 11 December 2006

Abstract

Purpose

Bone mass has been proposed as a marker of cumulative exposure to estrogen in women. We have studied the association between bone mass and the risk of breast cancer in postmenopausal women.

Methods

We investigated the association between bone mineral density (BMD), as measured at the lumbar spine and femoral neck, and the risk of breast cancer in women age 50 or older who had received an initial diagnosis of stage 0III breast cancer confirmed by pathologic assessment of breast tissue. We recruited 218 women with newly diagnosed breast cancer at Asan Medical Center from January 1, 2003 to December 31, 2004 and 963 women whose BMD was measured at the Health Promotion Center of Asan Medical Center as controls. Groups were divided by age: 5059 years old (Group A), 6069 years old (Group B), and over 70 years old (Group C). We compared BMD and prevalence of osteoporosis between groups. BMD was measured by lunar EXPERT-XL for breast cancer patients and Hologic QDR 4500-A for control group. A cross-calibration equation was used to compare BMD by different dual X-ray absorptiometry systems.

Results

BMD was significantly higher among breast cancer patients than controls at lumbar spine (p=0.04); femur neck BMD was higher but not statistically significant (p=0.47). After adjustment for age, the estimated odds ratio was 4.46 (p=0.02). In Group A, BMD for spine and femur neck was significantly higher in breast cancer patients (p<0.05). In Group B, spine BMD spine was significantly higher in breast cancer patients (p=0.005); femur neck BMD was higher but not statistically significant (p=0.24). In Group C, BMD for spine and femur neck was higher in breast cancer patients but not statistically significant (p>0.05). Prevalence of osteoporosis of the spine and femur neck was 14.9 and 4.6% for breast cancer patients and 19.6 and 8.3% for controls.

Conclusion

These results show that high bone mineral density has a strong relationship among breast cancer patients in postmenopausal women. In patients 70 years old or over, the age effect for bone mineral density decreased the effect of estrogen on bone.

Keywords: bone mineral density, breast cancer

Figures and Tables

Table 1

Descriptive characteristic of subjects.

BMI = Body mass index; BMD = Bone mineral density.

Table 2

BMD according to the stage.

BMD = Bone mineral density.

^*g/cm²

Table 3

Relative risk of breast cancer by bone mineral density.

Table 4

Bone mineral density of spine.

Table 5

Bone mineral density of femur neck.

Table 6

Prevalence of bone mineral density of spine.

Table 7

Prevalence of bone mineral density of femur neck.

Table 8

Difference of estradiol level

^*pg/ml

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