Approximately 7% of breast cancer patients are considered to have genetic predispositions for cancer [1]. The incidence of breast cancer is increasing in Korea, with an age-standardized incidence rate of 27.1% in 2009. The proportion of breast cancer patients with family histories of breast cancer is currently estimated to be 7.5% [2]. In some countries, individuals can consult with certified genetic counselors. In the United States and Canada, the National Society of Genetic Counselors provides genetic counseling information, guidelines and policies regarding genetic counseling, genetic testing services, and education of genetic counselors [3-6]. Although genetic counseling educational programs for patients with hereditary breast/ovarian cancer (HBOC) have been introduced in Korea, they are not widely available. The lack of awareness of genetic counseling as well as a shortage of qualified genetic counselors are impediments to effective education of individuals at high risk of HBOC [7,8].

There is a growing demand for genetic counseling worldwide, which has led to shortages of genetic counselors and delays in timely, qualified counseling. Researchers have examined educational strategies such as videoconference-based genetic counseling, training nurses as counselors, interactive computer educational programs, group counseling, and dissemination of information booklets to help patients make informed decisions about treatments [9-13]. As there is no certified genetic counselor training program in Korea, typically doctors and research nurses, rather than certified counselors, offer genetic counseling to patients with HBOC. The Korean Hereditary Breast Cancer (KOHBRA) Study Group, which investigates HBOC and BRCA mutations in Koreans, has initiated educational programs for genetic counselors to meet patient needs and provided counseling scripts and educational leaflets for patients.

The aim of the present study is to determine the effects of educational programs on healthcare providers' knowledge of, awareness of, and confidence in genetic counseling of individuals at high risk of HBOC.

The KOHBRA Study Group was organized in 2007 by the Korean Breast Cancer Society and is supported by the National Research and Development Program for Cancer Control of Korea. The KOHBRA Study Group has been investigating BRCA mutations in families with high risk of HBOC, developing a nationwide network of genetic counselors and providing genetic counseling services to families at high risk of HBOC.

A 3-day educational program on genetic counseling for patients at high risk of HBOC was conducted on June 24-26, 2011. The program included lectures (520 minutes) and hands-on practice sessions (400 minutes). The instructors were professionals in genetics, ethics, and psychiatry and expert clinicians in the management of hereditary breast cancer. The curriculum is described in Table 1. Hands-on practice sessions were held in a small-group discussion format to encourage the participation of all attendees. In risk assessment and pedigree drawing practice sessions, participants worked in pairs and performed the roles of counselee or counselor. A video of a mock genetic counseling session was shown before counseling practice sessions, and a counseling script was provided to each participant for practice.

Healthcare providers willing to participate in the educational program were enrolled and provided with a questionnaire and a knowledge test. Self-reported questionnaires that assessed awareness of and confidence during genetic counseling, using a 5-point Likert scale (strongly agree, agree, neutral, disagree, strongly disagree), were completed before and after the educational program. The questionnaires consists of three subscales: awareness of genetic counseling education (AW); confidence in one's expertise to perform counseling (AK), including history taking, psychological assessment, risk assessment, genetic testing, hereditary breast cancer, individual screening and treatment plan, and psychological support, and confidence in the skill to perform the counseling process (AS), including skills to convey knowledge of hereditary cancer and the risks and benefits of testing, and to guarantee patient's confidentiality. Total scores ranging from 1 to 5 were calculated by summing the items and dividing by the number of total items to obtain a mean value. The questionnaires had good internal consistency (Cronbach's α=0.924 preprogram, 0.966 postprogram). In the postprogram questionnaire, participants were able to describe additional opinions regarding their overall perception of the educational program. Participants also completed a 49-item knowledge test designed to evaluate the effects of each lecture. The test consisted of true/false questions and was based on the curriculum. Each participant had 20 minutes to complete the knowledge test. Lack of response to any test item was regarded as an incorrect answer. To prevent memorization of answers from the preprogram test, some of the questions were re-worded and re-sequenced on the postprogram test.

Statistical analyses were performed using SPSS version 15.0 (SPSS Inc., Chicago, USA) to detect changes in knowledge, awareness, and confidence, and to analyze the influences of different demographic factors (gender, occupation, prior education, and occupational experiences). p-values less than 0.05 were considered statistically significant. A paired t-test was used to analyze the knowledge test and questionnaire results. To identify the effect of previous differences between groups, a t-test was first performed on the preprogram questionnaire and knowledge test results. If significant difference were found between groups in the analysis of the preprogram questionnaire, the authors used an analysis of covariance (ANCOVA) in the postprogram survey to control for the effects of covariates. Otherwise, t-tests were used to assess postprogram survey data.

A total of 35 participants attended the genetic counseling educational program. Completed questionnaires assessing awareness and confidence (n=33) and paired knowledge tests (n=30) were analyzed. Table 2 describes the characteristics of the participants. Most were female (75.8%) and between the age of 30 and 39 years (81.8%). The percentages of doctors and nurses were similar (48.5%). Twenty-seven participants (81.8%) had more than 3 years of occupational experience. Nineteen participants (57.6%) had received prior genetic counseling education.

We conducted an organized genetic counseling educational program for HBOC in Korea and evaluated its effects by assessing participant knowledge and perceptions. The program resulted in significant improvements in knowledge, awareness, and confidence regarding genetic counseling. We introduced two specific concepts of educational science to measure the effect of the educational program. The first one was changing the structure and/or words of a question to prevent memorization of its answer. The other was related to statistics. If there were no difference in the preprogram knowledge score, the effects of the educational program can be evaluated by a between-groups comparison of the scores on the postprogram knowledge test, using a t-test. Otherwise, if significant differences were shown, the two groups were compared using analysis of covariance (ANCOVA), taking preprogram differences into consideration.

Although, overall participants showed increased knowledge after education, there were neither significant changes nor achievements in some subsections. Therefore, gradual education should be planned using itemized subsections of genetic counseling topics. A systematized core curriculum for genetic counseling is also required.

Male participants showed increased awareness and confidence after completing the program compared to female participants. Although significant differences were found in knowledge scores, occupational experience showed no influence on AW, AK, and AS. Attainment of knowledge is an important outcome of educational programs, because conveying knowledge about genetics is a critical skill in genetic counseling. However, achievement of confidence is also important from a "counseling" perspective, because confidence can influence the quality of counseling.

Prior experience with genetic counseling education was associated with elevated awareness before education and with increased confidence on the AK and AS scales. Repeated educational experiences may be essential for developing qualified genetic counselors. To maximize the efficacy of genetic counseling education, systematic education is required through learner analysis that considers participant gender, occupation, and knowledge status. Further evaluations of participants by using different analytical tools may be useful for learner analysis and instruction design [14].

The majority of participants in the educational program desired access to more-advanced programs regarding practice and counseling skills. In the educational program that was provided, participants performed mock genetic counseling through role-play. Although role-play has been shown to be effective for medical education and genetic counseling education, the lack of realism may be a barrier to improving communication skills [15,16]. Supervised genetic counseling practice would be helpful to enhance counseling skills. Lindh et al. [17] emphasized the importance, methods, and barriers of clinical supervision in genetic counseling training. Trial and error, student feedback, consultations with colleagues, and using methods employed by one's own supervisors were major resources. Supervised education by genetic counselors should also be planned in Korea.

The basic concepts of genetics are included in the curriculum of medical schools, but healthcare providers remain unfamiliar with the genetic counseling process [18]. Doctors and nurses who staff breast clinics are a well-prepared student group for genetic counseling education, because they already have knowledge of basic genetics and breast cancer. Effective organization of educational content can promote genetic counseling knowledge and skills. Organized instruction that considers specific areas of knowledge and counseling skills is also required to implement advanced educational plans and improve patient satisfaction [19].

The limitation of this study is that we have too few participants for sufficiently high statistical power. The educational program was advertised via e-mail, as well as made available to the members of The KOHBRA Study Group and the Korean Breast Cancer Society. Participation was voluntary, making it hard to control the number of subjects and related variables for the study. While the questionnaire's internal consistency was assessed, preprogram and postprogram knowledge tests were conducted differently to prevent the memorization of answers; therefore, this practice might have affected the level of difficulty. Although the knowledge test was devised to reflect the content of the educational program, we found decreased knowledge in some subsections.

Genetic counseling may be provided by not only clinical geneticists and certified genetic counselors but also nurses and other trained health care professionals. Having the latter conduct genetic counseling might be cost-effective, particularly in Korea, where fees for genetic counseling are not currently reimbursed by the nationwide universal insurance system. Systematized core curricula of genetic counseling for nurses and other primary care providers assisting clinical geneticists is in the process of being implemented in Korea [20-22]. These professionals could provide genetic counseling for HBOC in the future. In the present study, a genetic counseling educational program was shown to be useful to improve participant knowledge as well as enhance awareness and confidence. It was particularly beneficial for doctors. Collaboration between doctors and nurses is necessary to provide high-quality genetic counseling. Structured educational training programs regarding genetic counseling of patients at high risk of HBOC are needed to meet public demand in Korea.