The Prevalence of Ovarian Cancer in Korean Women at High-Risk for Hereditary Breast-Ovarian Cancer

Jihyoun Lee; Eunyoung Kang; Sung-Won Kim; Boyoung Park; Sue K. Park; Sei-Hyun Ahn; Hy-De Lee; Joon Jeong; Sung Hoo Jung; Byoung Kil Lee; Myung Chul Chang; Young Tae Bae; Young Up Cho; Ki-Tae Hwang; Hyun-Ah Kim; Eun-Kyu Kim; Nam Sun Paik; Sehwan Han; Chan Seok Yoon; Min Hyuk Lee

doi:10.4048/jbc.2011.14.S.S24

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Lee, Kang, Kim, Park, Park, Ahn, Lee, Jeong, Jung, Lee, Chang, Bae, Cho, Hwang, Kim, Kim, Paik, Han, Yoon, Lee, and Korean Breast Cancer Society: The Prevalence of Ovarian Cancer in Korean Women at High-Risk for Hereditary Breast-Ovarian Cancer

Original Article

Journal of Breast Cancer

Journal of Breast Cancer 2011; 14(Suppl 1): S24-S30.

Published online: 28 February 2011

DOI: https://doi.org/10.4048/jbc.2011.14.S.S24

The Prevalence of Ovarian Cancer in Korean Women at High-Risk for Hereditary Breast-Ovarian Cancer

Jihyoun Lee, Eunyoung Kang¹, Sung-Won Kim¹, Boyoung Park², Sue K. Park³, Sei-Hyun Ahn⁴, Hy-De Lee⁵, Joon Jeong⁵

, Sung Hoo Jung⁶, Byoung Kil Lee⁶, Myung Chul Chang⁷, Young Tae Bae⁸, Young Up Cho⁹, Ki-Tae Hwang¹⁰, Hyun-Ah Kim¹¹, Eun-Kyu Kim¹¹, Nam Sun Paik¹², Sehwan Han¹³, Chan Seok Yoon¹⁴, Min Hyuk Lee; Korean Breast Cancer Society¹⁵

Department of Surgery, Soonchunhyang University Hospital, Seoul, Korea.

¹Department of Surgery, Seoul National University Bundang Hospital, Seoul, Korea.

²Department of Preventive Medicine, Seoul National University College of Medicine, Cancer Research Institute, Seoul National University, Seoul, Korea.

³Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Korea.

⁴Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

⁵Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

⁶Department of Surgery, Chonbuk National University Medical School and Hospital, Jeonju, Korea.

⁷Department of Surgery, Dankook University Hospital, Cheonan, Korea.

⁸Department of Surgery, Pusan National University School of Medicine, Busan, Korea.

⁹Department of Surgery, Inha University College of Medicine, Incheon, Korea.

¹⁰Department of Surgery, Seoul National University Boramae Hospital, Seoul, Korea.

¹¹Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.

¹²Department of Surgery, Konkuk University Hospital, Seoul, Korea.

¹³Department of Surgery, Inje University Sanggye Paik Hospital, Seoul, Korea.

¹⁴Department of Surgery, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea.

¹⁵Korean Breast Cancer Society, Seoul, Korea.

Correspondence: min@sch.ac.kr

Received 31 December 2010 Accepted 10 February 2011

Abstract

Purpose

Few studies have reported ovarian cancer risks in Korean patients with the BRCA1/2 mutation. We investigated the prevalence of ovarian cancer in Korean women at high risk for hereditary breast-ovarian cancer (HBOC) syndrome and reviewed the clinicopathological factors of ovarian cancer.

Methods

Female subjects who were enrolled in the Korean Hereditary Breast Cancer study were included. The questionnaire included a personal and family history of cancer. The BRCA1/2 mutation and CA-125 level were tested at the time of enrollment. A transvaginal ultrasonogram (TVUS) was recommended for subjects with an elevated CA-125 level.

Results

A total of 1,689 patients were included. No ovarian cancer was newly diagnosed by CA-125 level or TVUS during the enrollment. The prevalence of ovarian cancer was 1.71% in BRCA1/2 mutation carriers and 0.39% in non-carriers. Among 11 patients with ovarian cancer, five had the BRCA1 mutation and one had the BRCA2 mutation. The most common histopathological type was serous cystadenocarcinoma. No difference in clinicopathological findings between BRCA1/2 mutation carriers and non-carriers was observed.

Conclusion

The prevalence of ovarian cancer was 58-fold elevated in women at high-risk for HBOC syndrome and 146-fold elevated in the BRCA1 subgroup, compared with the Korean general population. Further investigation with a long-term follow-up is required to evaluate BRCA1/2 gene penetrance.

Keywords: BRCA1/2 mutation, Ovarian neoplasms, Prevalence

Figures and Tables

Figure 1

Description of the subjects. (A) BRCA1/2 mutation of the female subjects. BRCA1 mutation was found 13.9% of the subjects. BRCA2 mutation was associated 8.0% of the subjects. Three subjects had both BRCA1 and BRCA2 mutation. BRCA1=BRCA1 mutation; BRCA2=BRCA2 mutation; BRCA1 and 2=BRCA1 and BRCA2 mutation. (B) History of oophorectomy. Eleven subjects had a history of ovarian cancer. Subjects who underwent the risk reducing salphingoophorectomy (RRSO) was only 8. Subjects received bilateral salphingooophorectomy (BSO) with benign disease was 3.2%.

Table 1

Characteristics and age distribution of the female KOHBRA subjects (n=1,689) enrolled from May 2007 to December 2010

KOHBRA=Korean Hereditary Breast Cancer Study.

Table 2

Prevalence and standardized prevalence ratio (SPR) of ovarian cancer

^*Early onset breast cancer patients under 40 years, breast cancer patients with family history of breast cancer (1st and 2nd degrees of relatives) and other primary cancers.

Table 3

Clinicopathologic features of ovarian cancer in high-risk Korean hereditary breast cancer families with or without BRCA1/2 mutation

^*Current International Federation of Obstetrics and Gynecology (FIGO) staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia.

Table 4

Comparison of reproductive risk factors

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ORCID iDs: Joon Jeong
https://orcid.org/http://orcid.org/0000-0003-0397-0005
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