A Study Regarding Predictive Factors for Malignancy of Papillary Lesions on Core Needle Biopsy of the Breast

Man Ho Ha; Jung Ah Lee; Seung Geun Lee; Gil Soo Son; Eeun Sook Lee; Jeoung Won Bae

doi:10.4048/jbc.2010.13.4.398

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Ha, Lee, Lee, Son, Lee, and Bae: A Study Regarding Predictive Factors for Malignancy of Papillary Lesions on Core Needle Biopsy of the Breast

Original Article

Journal of Breast Cancer

Journal of Breast Cancer 2010; 13(4): 398-402.

Published online: 31 December 2010

DOI: https://doi.org/10.4048/jbc.2010.13.4.398

A Study Regarding Predictive Factors for Malignancy of Papillary Lesions on Core Needle Biopsy of the Breast

Man Ho Ha, Jung Ah Lee, Seung Geun Lee, Gil Soo Son, Eeun Sook Lee, Jeoung Won Bae

Department of General Surgery, Korea University College of Medicine, Seoul, Korea.

Correspondence: kujwbae@korea.ac.kr

Received 30 July 2010 Accepted 5 October 2010

Abstract

Purpose

Diagnosing benign or malignant papillary lesions of the breast through core needle biopsy (CNB) is often difficult. The purpose of this study was to identify the predictive factors of malignancy.

Methods

We retrospectively reviewed the pathology database and found 80 consecutive patients who had been diagnosed with breast papillary lesions prior to surgery at two medical centers from May 2004 through May 2009. Those patients who had undergone CNB and had been diagnosed with either intraductal papilloma or malignant lesions following surgical excision were included.

Results

Forty-five cases were diagnosed as intraductal papilloma and 24 cases as malignant lesions. Malignancy was found to be related to being older than 60 years (p<0.01), having bloody nipple discharge (p=0.05), and a tumor size of more than 1 cm (p<0.01). Further, irregular shape (p<0.01) and uncircumscribed margin (p<0.01) on mammogram and irregular shape (p=0.04), calcification (p<0.01), and isoechoic pattern (p<0.01) on ultrasonogram were significantly related to malignancy.

Conclusion

Our study revealed that particular clinical factors and imaging findings correlated with malignant lesions. However, larger prospective studies are still necessary to establish treatment plans for patients diagnosed with papillary lesions on CNB.

Keywords: Breast, Malignancy, Needle biopsy, Papilloma

Figures and Tables

Figure 1

Results of 80 papillary lesions.

DCIS=ductal carcinoma in situ; IDC=infiltrating ductal carcinoma.

Table 1

Clinical feature of patients with papillary lesion

^*Fisher's exact test.

Table 2

Mammographic findings of breast papillary lesions

Table 3

Sonographic findings of breast papillary lesions

^*Fisher's exact test.

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