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Abstract
In women at high-risk for breast cancer with a BRCA mutation, bilateral prophylactic mastectomy (BPM) may achieve a risk reduction. A 35-year-old woman had a strong family history of breast and ovarian cancer. She had a regular checkup and found masses in both breasts that confirmed intraductal papillomas and atypical ductal hyperplasia after vacuum assisted mass excision. When she was referred to our clinic, the genetic testing for BRCA mutation was recommended to her sister that managed for ovarian cancer. It was resulted in the positive for the BRCA2 mutation, so she had checked the genetic testing which resulted in the same as the mutation. After sufficient counseling, she decided to undergo BPM and immediate reconstruction. She is satisfied with the result of surgery. This is the first report of BPM of asymptomatic BRCA2 mutation carrier in Korea and BPM should be considered as a risk-reducing option for BRCA mutation carriers.
Figures and Tables
Figure 1
Family pedigree. One of patient's sisters had breast cancer and the other sister has ovarian cancer. Patient has BRCA2 mutation. Arrow indicates patient.
ca=cancer; Lt.=left; DCIS=ductal carcinoma in situ.
Figure 2
Preoperative design. A bilateral nipple sparing total mastectomy with sentinel lymph node biopsy was performed. Note the multiple previous scars from vacuum assisted mass excision. Note the neck scar from previous right thyroid lobectomy with central lymph node dissection.
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