Malignant Fibrous Histiocytoma in the Breast: A Case Report

Jong Kyung Park; Seung Hye Choi; Seong Keun Kim; Sang Seob Yun; Jong Min Baek; Young Jin Suh; Woo Chan Park; Byung Joo Song; Se Jung Oh; Jeong Soo Kim; Seong Lee; Sang Seol Jung; Ki Ouk Min; Hyeon Sook Kim

doi:10.4048/jbc.2008.11.4.213

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Park, Choi, Kim, Yun, Baek, Suh, Park, Song, Oh, Kim, Lee, Jung, Min, and Kim: Malignant Fibrous Histiocytoma in the Breast: A Case Report

Case Report

Journal of Breast Cancer

Journal of Breast Cancer 2008; 11(4): 213-217.

Published online: 31 December 2008

DOI: https://doi.org/10.4048/jbc.2008.11.4.213

Malignant Fibrous Histiocytoma in the Breast: A Case Report

Jong Kyung Park, Seung Hye Choi, Seong Keun Kim, Sang Seob Yun, Jong Min Baek, Young Jin Suh, Woo Chan Park, Byung Joo Song, Se Jung Oh, Jeong Soo Kim, Seong Lee, Sang Seol Jung, Ki Ouk Min¹, Hyeon Sook Kim²

Department of Surgery, The Catholic University of Korea, College of Medicine, Seoul, Korea.

¹Department of Clinical Pathology, The Catholic University of Korea, College of Medicine, Seoul, Korea.

²Department of Radiology, The Catholic University of Korea, College of Medicine, Seoul, Korea.

gsshchoi@catholic.ac.kr

Received 3 December 2007 Accepted 12 August 2008

Abstract

Malignant fibrous histiocytoma is the most common form of soft tissue sarcoma during middle and late adulthood in the deep connective tissues of the extremities, abdominal cavity, and retroperitoneum. Primary breast sarcoma is a rare disease entity, comprising less than 1% of all breast malignancies. Malignant fibrous histiocytoma of the breast is very rare. We presented one case of a malignant fibrous histiocytoma of the right breast in a 49-year-old woman and report the case with a review of the literature.

Keywords: Breast, Fibrous histiocytoma, Malignant, Sarcoma

Figures and Tables

Fig 1

The ultrasonographic findings of malignant fibrous histiocytoma. Several large hypoechoic & isoechoic masses are noted in lower half of right breast and part of them are located in subcutaneous layer (A) and lymph nodes in right axilla are enlarged (B). These findings are included in BI-RADS category 5.

Fig 2

Histopathologic findings of malignant fibrous histiocytoma (A & B; ×40 & ×100, HE stain) Highly pleomorphic spindle shaped cells are observed in cellular tumor tissue. The tumor shows broad myxoid tissue (arrow) abutting cellular area (A) and fascicular pattern of pleomorphic spindle shaped cells (B).

Fig 3

PET-CT findings. Intense F-18 FDG accumulation (arrow) in subareolar and lower lateral portion of right breast (A) and several focal FDG uptake (arrow) in right axilla (B) are observed.

Fig 4

The mastectomy specimen. A relatively well circumscribed ovoid mass (arrow) is located beneath skin, which is 3.0×2.5 cm in size and has yellowish to pale gray myxoid and soft cut surface with focal hemorrhage.

Fig 5

Immunohistochemical staining of CD68 (×400). The tumor is positive for CD68.

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