Intracystic Papillary Carcinoma in the Male Breast: A Case Report

Sang Seob Yun; Seung Hye Choi; Seong Keun Kim; Jong Kyung Park; Jong Min Baek; Dong Ho Lee; Young Jin Seo; Woo Chan Park; Byung Joo Song; Se Jung Oh; Seong Lee; Sang Seol Jung; Eun Joo Seo; Ki Ouk Min

doi:10.4048/jbc.2008.11.3.151

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Yun, Choi, Kim, Park, Baek, Lee, Seo, Park, Song, Oh, Lee, Jung, Seo, and Min: Intracystic Papillary Carcinoma in the Male Breast: A Case Report

Case Report

Journal of Breast Cancer

Journal of Breast Cancer 2008; 11(3): 151-155.

Published online: 30 September 2008

DOI: https://doi.org/10.4048/jbc.2008.11.3.151

Intracystic Papillary Carcinoma in the Male Breast: A Case Report

Sang Seob Yun, Seung Hye Choi, Seong Keun Kim, Jong Kyung Park, Jong Min Baek, Dong Ho Lee, Young Jin Seo, Woo Chan Park, Byung Joo Song, Se Jung Oh, Seong Lee, Sang Seol Jung, Eun Joo Seo¹, Ki Ouk Min¹

Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

¹Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

gsshchoi@catholic.ac.kr

Received 3 December 2007 Accepted 12 August 2008

Abstract

Intracystic papillary carcinoma of the breast is a variant of ductal carcinoma in situ (DCIS) characterized by the presence of papillary carcinoma within a cystically dilated duct. DCIS of the male breast is an uncommon disease, accounting for approximately 7% of all male breast carcinomas. Most DCIS in men is of the papillary type. We experienced one case of intracystic papillary carcinoma in the right breast of a 49-yr-old male and report the case with a review of the literature.

Keywords: Male breast tumor, Intracystic papillary carcinoma

Figures and Tables

Fig 1

Ultrasonographic findings. This tumor is a 2.3×1.6 cm sized well marginated cystic mass with an internal fluid level (arrow) and an irregular solid component in the right subareolar area.

Fig 2

Fine needle aspiration cytology findings. There are two papillary structures consisting of a central core of stromal cells surrounded by layers of epithelial cells in a hemorrhagic background (H&E stain, ×100).

Fig 3

Gross specimen after excision. The tumor is a well-encapsulated round mass composed of friable solid tissue in a papillary pattern (arrow) and brown fluid.

Fig 4

Histopathologic findings (H&E stain A×100, B×200). Papillary proliferations of the tumor cells with a fibrovascular core within the cystically dilated duct are observed. The high power view shows the layering of tumor cells, loss of nuclear polarity, hyperchromasia and lack of myoepithelial cell layer.

Fig 5

Immunohistochemical stains of estrogen receptor is positive (A×200) and SMMHC is negative (B×200).

Table 1

Intracystic papillary carcinoma in the male breast: clinical feature and treatment

ALNM=Axillary lymph node metastasis; IHC=immunohistochemistry stain; CNB=Core needle biopsy; DCIS, ductal carcinoma in situ; SNB=Sentinel node biopsy; NA=not available; AC=Aspiration cytology; ALND=Axillary lymph node dissection.

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