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Abstract
Purpose
We analyzed the histopathologic findings of the patients with ultrasongraphic Breast Imaging Reporting and Data System (BI-RADS) Category 4a breast lesions to determine which patient can be excluded from any invasive, diagnostic procedure in the future.
Methods
Of the 180 cases of BI-RADS Category 4a breast lesions that were diagnosed with ultrasonography during a 6 month-period, 132 cases were pathologically confirmed and these were analyzed retrospectively. Four benign cases that did not undergo any further procedure after fine needle biopsy and 6 malignant cases (4.5%) were excluded from this study.
Results
Of the 122 cases, 77 cases (63.1%) showed homogeneous benign finding, and 45 cases (36.9%) showed heterogeneous finding that was made up of two or more different pathologic lesions. Fibroadenoma (55.8%) was the most frequent pathologic finding in the cases with homogeneous finding, followed by fibrocystic change (14.3%), and fibrosis (7.8%). The cases with heterogeneous finding presented fibrocystic change (55.5%), microcalcification (48.8%), ductal hyperplasia (42.2%), and fibroadenoma (31.1%) in the order of frequency.
Conclusion
Lesion with heterogeneous histopathologic nature was the most frequent finding defined as category 4a in breast ultrasonography, followed by fibrodenoma, fibrocystic change, microcalcification, and ductal hyperplasia. Refining more specific ultrasonographic findings of these lesions would guarantee that radiologists exclude more benign lesions from category 4a.
Figures and Tables
Fig 1
Fibroadenoma categorized as Category 4a. (A) The mass shows heterogeneous and low internal echo and it has microlobulated and angular margin. But its axis is parallel and it has posterior enhancement without peripheral thickening. The picture was scanned with ATL HDI 5000, Phillips, USA. (B) The picture was taken from the above lesion. Its stromal component shows marked fibrosis and lack of cellularity. (C) Cystically dilated ducts and tubular glands are seen in loose mixoid stroma (H&E, ×100).
Fig 2
Heterogeneous lesion defined as Category 4a. (A) The mass shows heterogeneous and low internal echo and it has microlobulated margin. It also has posterior acoustic shadowing in part. There is no secondary sign on the surrounding tissue, like architectural distortion, Cooper's ligament thickening or cutoff, peripheral thickening. The picture was scanned with ATL HDI 5000, Phillips, USA. (B) Several foci of ductal hyperplasia are seen on the top. Fibrocystic change is also seen on the bottom. (C) Microcalcification is in the dilated duct on the left of a large component of adenosis (H&E, ×100).
Table 2
Methods of biopsy and pathologic patterns of benign lesions defined as Category 4a in ultrasonography
Table 3
Malignant lesions defined as category 4a in ultrasonography
LCIS=lobular carcinoma in situ; DCIS=ductal carcinoma in situ.
*CNB is an abbreviation for core needle biopsy, which was done with 14-gauge automated biopsy gun under the guidance of ultrasonography; †Mammotome biopsy was done with 11-gauge vacuum-assisted probe under the guidance of ultrasonography.
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