The Clinical and Histopathological Characteristics of Male Breast Cancer Patients

Jihyoung Cho; Wonshik Han; Eunyoung Ko; Jong Won Lee; So-Youn Jung; Eun-Kyu Kim; Ho-Chang Lee; In-Ae Park; Seung Keun Oh; Yeo Kyu Youn; Sung-Won Kim; Ki-Tae Hwang; Dong-Young Noh

doi:10.4048/jbc.2007.10.3.211

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Cho, Han, Ko, Lee, Jung, Kim, Lee, Park, Oh, Youn, Kim, Hwang, and Noh: The Clinical and Histopathological Characteristics of Male Breast Cancer Patients

Original Article

Journal of Breast Cancer

Journal of Breast Cancer 2007; 10(3): 211-216.

Published online: 30 September 2007

DOI: https://doi.org/10.4048/jbc.2007.10.3.211

The Clinical and Histopathological Characteristics of Male Breast Cancer Patients

Jihyoung Cho, Wonshik Han, Eunyoung Ko, Jong Won Lee, So-Youn Jung, Eun-Kyu Kim, Ho-Chang Lee¹, In-Ae Park¹, Seung Keun Oh, Yeo Kyu Youn, Sung-Won Kim, Ki-Tae Hwang, Dong-Young Noh

Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

¹Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.

dynoh@snu.ac.kr

Received 7 May 2007 Accepted 21 June 2007

Abstract

Purpose

Breast cancer in male is uncommon, accounting for approximately 1% of all breast cancer and less than 1.5% of all the malignant neoplasms in males. The information concerned with the treatment of male breast cancer is limited. The objective of this study is to evaluate the histopathologic characteristics and clinical outcome of male breast cancer patients.

Methods

We retrospectively analyzed the medical record of 17 male breast cancer patients who had been operated on Seoul National University Hospital between 1996 and 2006.

Results

The peak age of incidence was the 6th decade and the mean age of the patients was 56.2 yr. The most common symptom was a palpable mass and the mean duration of symptoms was 13 months. Fifty-three percent of the patients were stage 0 or I. Mastectomy was performed in 15 cases and lumpectomy was performed in 2 cases. Twelve patients received adjuvant hormonal therapy. The median duration of follow up was 28 months. Of the two patients with distant relapse, one patient died due to multiple metastasis and the other patient is still alive. The other patients are still alive without any evidence of metastasis or recurrence.

Conclusion

Active diagnosis, appropriate treatments (surgery and adjuvant therapy) and close follow up are necessary for male patients who have a palpable mass in their breast.

Keywords: Male breast cancer

Figures and Tables

Table 1

Age distribution

Table 2

Clinical manifestations

Table 3

Type of diagnostic procedure

Table 4

Pathologic characteristics

NG=Nuclear grade; HG=Histologic grade; LVI=Lymphovascular invasion; ER=Estrogen receptor; PR=Progesteron receptor; DCIS=Ductal carcinoma in situ; IDC=Invasive ductal carcinoma.

Table 5

Surgical & adjuvant therapy

RM=Radical mastectomy; ALND=Axillary lymph node dissection; MRM=Modified radical mastectomy; SLNB=Sentinel lymph node biopsy.

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