Web Interface Generator of Ontology Based CRF for Clinical Trial in Western and Oriental Medicine

Jinseok Moon; Kyungmo Park; Sunmi Choi

doi:10.4258/jksmi.2009.15.1.59

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Moon, Park, and Choi: Web Interface Generator of Ontology Based CRF for Clinical Trial in Western and Oriental Medicine

Original Article

Journal of Korean Society of Medical Informatics

Journal of Korean Society of Medical Informatics 2009; 15(1): 59-69.

Published online: 31 March 2009

DOI: https://doi.org/10.4258/jksmi.2009.15.1.59

Web Interface Generator of Ontology Based CRF for Clinical Trial in Western and Oriental Medicine

Jinseok Moon¹, Kyungmo Park², Sunmi Choi¹

¹Korea Institute of Oriental Medicine, Korea.

²Department of Biomedical Engineering, Kyunghee University, Korea.

Corresponding Author (moonstone2@kiom.re.kr)

Received 18 November 2008 Accepted 9 March 2009

Abstract

Objective

This study aims to develop the web-interface creator, which automatically changes the Case Report Form(CRF) web page when the protocol developer in any clinical study revises the ontology of CRF.

Methods

This study established the conceptual model of CRF on oriental and western medicine, and developed ontologies. A program was developed to produce online-based a input form through the parser that generates automatically HTML script from OWL.

Results

The CRF applied in this study is a draft through consensus of experts for stroke research at the Korea Institute of Oriental Medicine. The ontology of CRF consisted of Label, ControlType and Value classes and hasControl, hasValue and hasSymptoms properties. The Label is the class of question items groups, so it could have CRF questionnaire instances. The ControlType is the class that expresses controls such as checkbox, text, etc in the HTML script. The Value class represents selections for each items. Finally, the HTML script was created by XSL transformation from the OWL script.

Conclusion

Online-based automatic interface creation, which enables immediate coping with the continuous change in the medical knowledge system, assures reduced time requirement.

Keywords: Ontology, OWL, XSLT, Electronic Case Report Form, Clinical Research

Figures and Tables

Figure 1

Sequence diagram of e-CRF

Figure 2

Process of programming

Figure 3

Conceptual framework for patient findings-ISO/TC 215 DTS 22789

Figure 4

Conceptual model of OntoCRF in cerebrovascular disease

Figure 5

Classes(left) and properties(right)

Figure 6

ControlType instance

Figure 7

Instance Tab

Figure 8

hasValue property

Figure 9

hasUnit property

Figure 10

Structured view of OntoCRF by OntoViz

Figure 11

Relationship View using TGVizTab

Figure 12

Queries tab to search instances

Figure 13

XSL algorithms for transformation from OWL to HTML

Figure 14

Output to HTML

References

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