Journal List > Infect Chemother > v.44(6) > 1035211

Nam, Kim, Doo, Jung, Lee, Kim, Park, Min, Ko, and Pai: A Case of Dengue Fever with Maculopathy

Abstract

Dengue fever is transmitted principally by Aedes aegypti, which is not infested in Korea. Therefore, all Korean patients with dengue fever are imported cases from endemic areas such as Southeast Asia. Although disease manifestation and complication of dengue fever are various, ocular involvement is rare. We encountered a patient infected with dengue virus, imported from the Philippines. After defervescence from dengue fever, he complained of blurred vision. Blot hemorrhage with retinal infiltration in the macular area was observed in both eyes. Maculopathy by dengue fever was treated with systemic and intraocular glucocorticoid for two weeks; his ocular condition then showed improvement.

Figures and Tables

Figure 1
Color photographs of the fundus at initial presentation (A, B) shows blot hemorrhages and several yellowish infiltrates spots around both maculae in both eyes (A/B=Rt eye/Lt eye).
ic-44-504-g001
Figure 2
SD-OCT shows macular edema in both eyes (A/B=Rt eye/Lt eye).
ic-44-504-g002
Figure 3
Color photographs of the fundus(A, B) shows resolution of spot hemorrhage and retinal infiltrates in both eyes (23 days after treatment) (A/B=Rt eye/Lt eye).
ic-44-504-g003

References

1. Rigau-Pérez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV. Dengue and dengue haemorrhagic fever. Lancet. 1998. 352:971–977.
crossref
2. Choi MH, Choo EJ, Kim TH, Jeon MH, Park EJ, Shin DW, Yi SH, Choi JH. Four cases of dengue fever-dengue hemorrhagic fever and domestic literature review. Infect Chemother. 2008. 40:350–354.
crossref
3. Choi SH, Kim YJ, Shin JH, Yoo KH, Sung KW, Koo HH. International travel of Korean children and Dengue fever: A single institutional analysis. Korean J Pediatr. 2010. 53:701–704.
crossref
4. Yu CH, Choi TG, Choi WY, Ju YR, Jin SH, Park KY. Positive rate of antibody against dengue virus for Korean who traveled to dengue epidemic area. Infect Chemother. 2004. 36:234–240.
5. Kwon SR, Cho BK, Yoon SJ, Cho YB, Kim IK, Park BJ, Chung MH. A case of dengue hemorrhagic fever imported from Africa. Korean J Infect Dis. 2000. 32:467–469.
6. Su DH, Bacsal K, Chee SP, Flores JV, Lim WK, Cheng BC, Jap AH. Dengue Maculopathy Study Group. Prevalence of dengue maculopathy in patients hospitalized for dengue fever. Ophthalmology. 2007. 114:1743–1747.
crossref
7. Chung MH. Dengue fever. Korean J Med. 2009. 77:165–170.
crossref
8. Wilder-Smith A, Schwartz E. Dengue in travelers. N Engl J Med. 2005. 353:924–932.
crossref
9. Suh SJ, Seo YS, Ahn JH, Park EB, Lee SJ, Sohn JU, Um SH. A case of imported dengue fever with acute hepatitis. Korean J Hepatol. 2007. 13:556–559.
crossref
10. Kang YJ, Choi SY, Kang IJ, Lee JE, Seo MH, Lee TH, Ghim BK. Dengue fever mimicking acute appendicitis: a case report. Infect Chemother. 2009. 41:236–239.
crossref
11. Choi ES, Kim JM, Yi HA, Ryu SY. Meningitis associated dengue fever imported from Vietnam. J Korean Neurol Assoc. 2011. 29:37–39.
12. Park IH, Kim YA, Shin SY, Park YS, Yoon HJ, Kim CO, Park YS, Choi JY, Huh AJ, Song YG, Kim JM. A case of dengue fever complicated by rhabdomyolysis. Infect Chemother. 2005. 37:234–236.
13. Lim WK, Mathur R, Koh A, Yeoh R, Chee SP. Ocular manifestations of dengue fever. Ophthalmology. 2004. 111:2057–2064.
crossref
14. Kapoor HK, Bhai S, John M, Xavier J. Ocular manifestations of dengue fever in an East Indian epidemic. Can J Ophthalmol. 2006. 41:741–746.
crossref
15. Wen KH, Sheu MM, Chung CB, Wang HZ, Chen CW. The ocular fundus findings in dengue fever. Gaoxiong Yi Xue Ke Xue Za Zhi. 1989. 5:24–30.
16. Tan CS, Teoh SC, Chan DP, Wong IB, Lim TH. Dengue retinopathy manifesting with bilateral vasculitis and macular oedema. Eye (Lond). 2007. 21:875–877.
crossref
17. Loh BK, Bacsal K, Chee SP, Cheng BC, Wong D. Foveolitis associated with dengue Fever: a case series. Ophthalmologica. 2008. 222:317–320.
crossref
18. Teoh SC, Chee CK, Laude A, Goh KY, Barkham T, Ang BS. Eye Institute Dengue-related Ophthalmic Complications Work-group. Optical coherence tomography patterns as predictors of visual outcome in dengue-related maculopathy. Retina. 2010. 30:390–398.
crossref
19. Rothman AL. Immunology and immunopathogenesis of dengue disease. Adv Virus Res. 2003. 60:397–419.
crossref
20. Haritoglou C, Dotse SD, Rudolph G, Stephan CM, Thurau SR, Klauss V. A tourist with dengue fever and visual loss. Lancet. 2002. 360:1070.
crossref
TOOLS
Similar articles