Rifampin-resistant Relapsed Tuberculosis Confirmed by Molecular Technique

Song Mi Moon; Sang-Oh Lee; Sang-Ho Choi; Yang Soo Kim; Jun Hee Woo; Sung-Han Kim

doi:10.3947/ic.2012.44.6.485

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Moon, Lee, Choi, Kim, Woo, and Kim: Rifampin-resistant Relapsed Tuberculosis Confirmed by Molecular Technique

Case Report

Infection & Chemotherapy

Infection & Chemotherapy 2012; 44(6): 485-490.

Published online: 31 December 2012

DOI: https://doi.org/10.3947/ic.2012.44.6.485

Rifampin-resistant Relapsed Tuberculosis Confirmed by Molecular Technique

Song Mi Moon, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim

Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Correspondence to Sung-Han Kim, M.D. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 388-1Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Tel: +82-2-3010-3305, Fax: +82-2-3010-6970, kimsunghanmd@hotmail.com

Received 25 April 2012 Revised 24 July 2012 Accepted 31 July 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recurrent tuberculosis can be caused by a relapse of the original infecting strain, a reinfection with a new strain of Mycobacterium tuberculosis or a paradoxical response associated with the anti-tuberculosis treatment. A drug susceptibility test is important when evaluating recurrent tuberculosis but a conventional microbiological test may be unavailable or unsuccessful. Recently, direct molecular testing as a line probe assay (GenoType® MTBDRplus, Hain Lifescience GmbH, Nehren, Germany) has shown promising results for the diagnosis or treatment of drug-resistant tuberculosis. We present two cases of rifampin-resistant, relapsed tuberculosis that were confirmed using a molecular technique.

Keywords: Mycobacterium tuberculosis, Rifampin, Drug resistance

Figures and Tables

Table 1

Diagnosis and Treatment of Rifampin-resistant Relapsed Tuberculosis Cases

TB, tuberculosis; AFB, acid-fast bacilli; PCR, polymerase chain reaction; INH, isoniazie; RFP, rifampin, EMB, ethambutol; PZA, pyrazinamide

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