Journal List > Infect Chemother > v.44(6) > 1035191

Go, Kim, Han, Lee, Kim, and Kang: Nasopharyngeal Colonization of Moraxella catarrhalis in Young Korean Children

Abstract

Background

Nasopharyngeal bacterial flora can cause respiratory tract diseases as well as invasive bacterial diseases. Moraxella catarrhalis colonizing in the nasopharynx is considered an important potential pathogen with an increasing production of β-lactamase. This study examined the nasopharyngeal colonization rate of M. catarrhalis and the antibiotic susceptibility of M. catarrhalis.

Materials and Methods

Healthy children who visited one of the three University hospitals in the Republic of Korea or attended a day-care center around the participating hospitals were enrolled in this study. The nasopharyngeal samples were obtained by nasopharyngeal washing with normal saline and M. catarrhalis was isolated. The nasopharyngeal colonization rate of M. catarrhalis was investigated and the minimal inhibitory concentrations (MICs) were measured for commonly used oral antibiotics (amoxicillin, amoxicillin/clavulanate, cefaclor, cefixime, cefdinir, cefditoren, erythromycin and trimethoprim).

Results

Three hundred and seventy-nine children aged between 6 months and 5 years were enrolled, and the nasopharyngeal colonization rate of M. catarrhalis was 33% (124 children). All isolated M. catarrhalis produced β-lactamase. The MIC90 of the antibiotics were as follows: amoxicillin, >16 mg/L; amoxicillin/clavulanate, 0.5 mg/L; cefaclor, 8 mg/L ; cefixime, 0.125 mg/L; cefdinir, 0.25 mg/L; cefditoren, 0.25 mg/L; erythromycin, 0.5 mg/L; and trimethoprim, >16 mg/L.

Conclusions

M. catarrhalis was colonized in 33% of the children aged 6 months to 5 years, and showed low MICs for amoxicillin/clavulanate and oral 2nd and 3rd generation cephalosporins.

Figures and Tables

Table 1
Proportions of Children with Nasopharyngeal Colonization of Moraxella catarrhalis and Those without Colonization
ic-44-426-i001

aSD, standard deviation.

bThe P -value was calculated using Mann-Whitney test.

cThe P -value was calculated by Chi-square analysis.

Table 2
In vitro Activity of Common Oral Antibiotics against Moraxella catarrhalis Isolated from the Nasopharyngeal Cavities of the Healthy Children
ic-44-426-i002

aMIC, minimal inhibitory concentration.

bThe breakpoint is for Haemophilus influenzae, and is recommended by the Clinical and Laboratory Standards Institute (CLSI).

cThe susceptibility was calculated based on the breakpoint for Haemophilus influenzae recommended by the CLSI.

dNA, not available.

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