Frequency of N. gonorrheaee, C. trachomatis, U. urealyticum and M. hominis in Pelvic Inflammatory Disease and Fitz-Hugh-Curtis Syndrome

Gyoung Hoon Lee; Hye Ji Kim; Chul Hi Park; Yoon Jung Chun; Hyun Jung Choi; Han Na Lee; Sook Cho

doi:10.3947/ic.2012.44.5.362

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Lee, Kim, Park, Chun, Choi, Lee, and Cho: Frequency of N. gonorrheaee, C. trachomatis, U. urealyticum and M. hominis in Pelvic Inflammatory Disease and Fitz-Hugh-Curtis Syndrome

Original Article

Infection & Chemotherapy

Infection & Chemotherapy 2012; 44(5): 362-366.

Published online: 31 October 2012

DOI: https://doi.org/10.3947/ic.2012.44.5.362

Frequency of N. gonorrheaee, C. trachomatis, U. urealyticum and M. hominis in Pelvic Inflammatory Disease and Fitz-Hugh-Curtis Syndrome

Gyoung Hoon Lee¹, Hye Ji Kim¹, Chul Hi Park², Yoon Jung Chun¹, Hyun Jung Choi¹, Han Na Lee¹, Sook Cho¹

¹Department of Obstetrics and Gynecology, Seoul Medical Center, Seoul, Korea.

²Department of Radiology, Seoul Medical Center, Seoul, Korea.

Correspondence to Lee Gyoung Hoon, M.D. Department of Obstetrics and Gynecology, Seoul Medical Center, Seoul 131-130, Korea. Tel: +82-2-2276-8916, Fax: +82-2-3410-8082, ghleeobgy@gmail.com

Received 1 March 2012 Revised 21 June 2012 Accepted 6 July 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Pelvic inflammatory disease (PID) is a common genital tract infection in reproductive women. This study aimed to determine the frequency of Neisseria gonorrheae, Chlamydia trachomatis, Ureaplasma urealyticum, and Mycoplasma hominis in Pelvic inflammatory disease (PID), and to further sub-analyze the clinical characteristics in patients diagnosed with Fitz-Hugh-Curtis syndrome (FHCS).

Material and Methods

Sixty-six patients diagnosed clinically as PID were recruited from April, 2007 to February, 2011. Retrospective chart review was performed for investigating the characteristics of the clinical manifestation, laboratory findings, and image findings. And then all subjects were classified into two groups, the PID-only group and the FHCS group, depending on whether or not computed tomography showed increased perihepatic enhancement. Samples obtained in endocervical swabs were tested using Roche COBAS Amplicor Polymerase-chain reaction (PCR) for N. gonorrheae, C. trachomatis, U. urealyticum, and M. hominis.

Results

The 66 PID patients ranged in age from 19 to 49 years. Thirty nine patients were diagnosed as having an inflammation localized only in the lower abdomen (PID only), and 27 patients were diagnosed as FHCS. According to results of PCR, U. urealyticum was found most commonly in both the PID-only group and the FHCS group (66.7% and 59.3%, respectively).

Conclusions

Organisms other than C. trachomatis and N. gonorrheae, particularly U. urealyticum, may be detected more frequently in PID patients in Korea. In addition, identification of ^{M. hominis} may be of importance in female health problems such as FHCS.

Keywords: Pelvic inflammatory disease, Fitz-Hugh-Curtis Syndrome, Ureaplsama urealyticum, Mycoplasma homini

Figures and Tables

Table 1

Baseline Characteristics of Women Diagnosed as the PID-only Group and the FHCS Group

PID, pelvic inflammatory disease; FHCS, Fitz-Hugh-Curtis syndrome.

Table 2

Clinical Symptoms of Women Diagnosed as the PID-only Group and the FHCS Group

RUQ, right upper quadrant; GI complaints, Gastro-intestinal complaints (i.e., nausea, vomiting, upper gastric pain and diarrhea)

Table 3

Laboratory Characteristics of Women Diagnosed as the PID-only Group and the FHCS Group

WBC, white blood cell count (/mm³, 4,000-10,000); CRP, C-reactive protein (mg/dl, 0.0-0.4); T.bil., total bilirubin (mg/dL, 0-1.3); ALT, Alanine transaminase (U/L, 0-40); AST, Aspartate transaminase (U/L,0-40); ALP, Alkaline phosphatase (U/L, 30-125)

Table 4

The Prevalence of Causative Organisms of Infection in Women Diagnosed as the PID-only Group and the FHCS Group

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