Journal List > Infect Chemother > v.44(3) > 1035139

Infect Chemother. 2012 Jun;44(3):140-163. Korean.
Published online June 30, 2012.  https://doi.org/10.3947/ic.2012.44.3.140
Copyright © 2012 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy
Clinical Practice Guidelines for the Management of Bacterial Meningitis in Adults in Korea
The Korean Society of Infectious Diseases The Korean Society for Chemotherapy The Korean Neurological Association The Korean Neurosurgical Society and The Korean Society of Clinical Microbiology

Correspondence to the Committee of the Korean Society for Chemotherapy for Development of Clinical Practice Guidelines of Central Nervous System Infections. The Korean Society for AIDS, Asterium g1203, Maezllan 21, Samseong-dong 158-10, Kangnam-gu, Seoul 135-880, Korea. Tel: +82-2-557-1755, Fax: +82-2-6499-1755, Email: kosa@kosaids.or.kr

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Successful treatment of bacterial meningitis in adults requires a rapid and accurate etiologic diagnosis, appropriate empirical therapy, and adjunctive treatment. Etiology and antimicrobial susceptibility of major pathogens of meningitis can differ by country. Ideal clinical practice guidelines for the management of bacterial meningitis in Korea should be based on studies conducted in Korea. We developed clinical practice guidelines for the management of bacterial meningitis in adults in Korea by adaptation of existing foreign guidelines. These guidelines were developed by the joint committee of the Korean Society for Chemotherapy, the Korean Society of Infectious Diseases, the Korean Neurological Association, the Korean Neurosurgical Society, and the Korean Society of Clinical Microbiology.

Keywords: Practice guideline; Meningitis; Adult

Tables


Table 1
Strength of Recommendation and Quality of Evidence
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Table 2
Indications of Imaging of the Brain Prior to Lumbar Puncture
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Table 3
Comparison of Cerebrospinal Fluid findings of Meningitis
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Table 4
Antibiotics Recommended for Empirical Therapy in Patients with Suspected Bacterial Meningitis
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Table 5
Recommendations for Specific Antimicrobial Therapy in Bacterial Meningitis based on Isolated Microorganism and Susceptibility Test
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Table 6
Duration of Antimicrobial Therapy for Bacterial Meningitis based on the Isolated Pathogen
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References
1. Park SA, Cheon HY, Choi IS. Clinical characteristics of meningitis in adults. J Korean Neurol Assoc 1997;15:1050–1063.
2. Moon SY, Chung DR, Kim SW, Chang HH, Lee H, Jung DS, Kim YS, Jung SI, Ryu SY, Heo ST, Moon C, Ki HK, Son JS, Kwon KT, Shin SY, Lee JS, Lee SS, Rhee JY, Lee JA, Joung MK, Cheong HS, Peck KR, Song JH. Changing etiology of community-acquired bacterial meningitis in adults: a nationwide multicenter study in Korea. Eur J Clin Microbiol Infect Dis 2010;29:793–800.
3. Chaudhuri A, Martinez-Martin P, Kennedy PG, Andrew Seaton R, Portegies P, Bojar M, Steiner I. EFNS Task Force. EFNS guideline on the management of community-acquired bacterial meningitis: report of an EFNS Task Force on acute bacterial meningitis in older children and adults. Eur J Neurol 2008;15:649–659.
4. Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004;39:1267–1284.
5. Société de pathologie infectieuse de langue française (SPILF). Practice guidelines for acute bacterial meningitidis (except newborn and nosocomial meningitis). Med Mal Infect 2009;39:356–367.
6. Begg N, Cartwright KA, Cohen J, Kaczmarski EB, Innes JA, Leen CL, Nathwani D, Singer M, Southgate L, Todd WT, Welsby PD, Wood MJ. British Infection Society Working Party. Consensus statement on diagnosis, investigation, treatment and prevention of acute bacterial meningitis in immunocompetent adults. J Infect 1999;39:1–15.
7. Visintin C, Mugglestone MA, Fields EJ, Jacklin P, Murphy MS, Pollard AJ. Guideline Development Group; National Institute for Health and Clinical Excellence. Management of bacterial meningitis and meningococcal septicaemia in children and young people: summary of NICE guidance. BMJ 2010;340:c3209.
8. Horwitz SJ, Boxerbaum B, O'Bell J. Cerebral herniation in bacterial meningitis in childhood. Ann Neurol 1980;7:524–528.
9. Korein J, Cravioto H, Leicach M. Reevaluation of lumbar puncture; a study of 129 patients with papilledema or intracranial hypertension. Neurology 1959;9:290–297.
10. Gopal AK, Whitehouse JD, Simel DL, Corey GR. Cranial computed tomography before lumbar puncture: a prospective clinical evaluation. Arch Intern Med 1999;159:2681–2685.
11. Hasbun R, Abrahams J, Jekel J, Quagliarello VJ. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med 2001;345:1727–1733.
12. Wylie PA, Stevens D, Drake W 3rd, Stuart J, Cartwright K. Epidemiology and clinical management of meningococcal disease in west Gloucestershire: retrospective, population based study. BMJ 1997;315:774–779.
13. Greenlee JE, Carroll KC. Cerebrospinal fluid in CNS infections. In: Scheld WM, Whitley RJ, Durack DT, editors. Infections of the central nervous system. 2nd ed. Philadelphia: Lippincott-Raven; 1997. pp. 899-922.
14. Genton B, Berger JP. Cerebrospinal fluid lactate in 78 cases of adult meningitis. Intensive Care Med 1990;16:196–200.
15. Leib SL, Boscacci R, Gratzl O, Zimmerli W. Predictive value of cerebrospinal fluid (CSF) lactate level versus CSF/blood glucose ratio for the diagnosis of bacterial meningitis following neurosurgery. Clin Infect Dis 1999;29:69–74.
16. Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S. Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis. J Infect 2011;62:255–262.
17. Huy NT, Thao NT, Diep DT, Kikuchi M, Zamora J, Hirayama K. Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis. Crit Care 2010;14:R240.
18. Gerdes LU, Jorgensen PE, Nexo E, Wang P. C-reactive protein and bacterial meningitis: a meta-analysis. Scand J Clin Lab Invest 1998;58:383–393.
19. Ray P, Badarou-Acossi G, Viallon A, Boutoille D, Arthaud M, Trystram D, Riou B. Accuracy of the cerebrospinal fluid results to differentiate bacterial from non bacterial meningitis, in case of negative gram-stained smear. Am J Emerg Med 2007;25:179–184.
20. Park JW, Chung SW, Ko SB, Choi YB, Lee KS. Predictive value of C-reactive protein in the differential diagnosis of acute meningitis in adults. J Korean Neurol Assoc 2003;21:248–254.
21. Gendrel D, Raymond J, Assicot M, Moulin F, Iniguez JL, Lebon P, Bohuon C. Measurement of procalcitonin levels in children with bacterial or viral meningitis. Clin Infect Dis 1997;24:1240–1242.
22. Viallon A, Zeni F, Lambert C, Pozzetto B, Tardy B, Venet C, Bertrand JC. High sensitivity and specificity of serum procalcitonin levels in adults with bacterial meningitis. Clin Infect Dis 1999;28:1313–1316.
23. Schwarz S, Bertram M, Schwab S, Andrassy K, Hacke W. Serum procalcitonin levels in bacterial and abacterial meningitis. Crit Care Med 2000;28:1828–1832.
24. Viallon A, Desseigne N, Marjollet O, Birynczyk A, Belin M, Guyomarch S, Borg J, Pozetto B, Bertrand JC, Zeni F. Meningitis in adult patients with a negative direct cerebrospinal fluid examination: value of cytochemical markers for differential diagnosis. Crit Care 2011;15:R136.
25. Tuon FF, Higashino HR, Lopes MI, Litvoc MN, Atomiya AN, Antonangelo L, Leite OM. Adenosine deaminase and tuberculous meningitis--a systematic review with meta-analysis. Scand J Infect Dis 2010;42:198–207.
26. Moghtaderi A, Niazi A, Alavi-Naini R, Yaghoobi S, Narouie B. Comparative analysis of cerebrospinal fluid adenosine deaminase in tuberculous and non-tuberculous meningitis. Clin Neurol Neurosurg 2010;112:459–462.
27. Sun Q, Sha W, Xiao HP, Tian Q, Zhu H. Evaluation of Cerebrospinal Fluid Adenosine Deaminase Activity for the Differential Diagnosis of Tuberculous and Nontuberculous Meningitis. Am J Med Sci. 2011
[in press].
28. Kashyap RS, Kainthla RP, Mudaliar AV, Purohit HJ, Taori GM, Daginawala HF. Cerebrospinal fluid adenosine deaminase activity: a complimentary tool in the early diagnosis of tuberculous meningitis. Cerebrospinal Fluid Res 2006;3:5.
29. Kim KI, Lee AY, Hong YE, Kim J, Kim JM. Studies on adenosine deaminase (ADA) activity in the cerebrospinal fluid of tuberculous meningitis (TBM). J Korean Neurol Assoc 1998;16:302–306.
30. Choi SH, Kim YS, Bae IG, Chung JW, Lee MS, Kang JM, Ryu J, Woo JH. The possible role of cerebrospinal fluid adenosine deaminase activity in the diagnosis of tuberculous meningitis in adults. Clin Neurol Neurosurg 2002;104:10–15.
31. Tunkel AR. In: Bacterial meningitis. Philadelphia: Lippincott Williams & Wilkins; 2001.
32. La Scolea LJ Jr, Dryja D. Quantitation of bacteria in cerebrospinal fluid and blood of children with meningitis and its diagnostic significance. J Clin Microbiol 1984;19:187–190.
33. Chapin-Robertson K, Dahlberg SE, Edberg SC. Clinical and laboratory analyses of cytospin-prepared Gram stains for recovery and diagnosis of bacteria from sterile body fluids. J Clin Microbiol 1992;30:377–380.
34. Gray LD, Fedorko DP. Laboratory diagnosis of bacterial meningitis. Clin Microbiol Rev 1992;5:130–145.
35. Mylonakis E, Hohmann EL, Calderwood SB. Central nervous system infection with Listeria monocytogenes 33 years' experience at a general hospital and review of 776 episodes from the literature. Medicine (Baltimore) 1998;77:313–336.
36. Maxson S, Lewno MJ, Schutze GE. Clinical usefulness of cerebrospinal fluid bacterial antigen studies. J Pediatr 1994;125:235–238.
37. Tarafdar K, Rao S, Recco RA, Zaman MM. Lack of sensitivity of the latex agglutination test to detect bacterial antigen in the cerebrospinal fluid of patients with culture-negative meningitis. Clin Infect Dis 2001;33:406–408.
38. Kim MN, Pai CH. Utility of latex agglutination test in the laboratory diagnosis of bacterial meningitis. Korean J Clin Pathol 1998;18:584–590.
39. Ni H, Knight AI, Cartwright K, Palmer WH, McFadden J. Polymerase chain reaction for diagnosis of meningococcal meningitis. Lancet 1992;340:1432–1434.
40. Rådström P, Bäckman A, Qian N, Kragsbjerg P, Påhlson C, Olcén P. Detection of bacterial DNA in cerebrospinal fluid by an assay for simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and streptococci using a seminested PCR strategy. J Clin Microbiol 1994;32:2738–2744.
41. Chiba N, Murayama SY, Morozumi M, Nakayama E, Okada T, Iwata S, Sunakawa K, Ubukata K. Rapid detection of eight causative pathogens for the diagnosis of bacterial meningitis by real-time PCR. J Infect Chemother 2009;15:92–98.
42. Welinder-Olsson C, Dotevall L, Hogevik H, Jungnelius R, Trollfors B, Wahl M, Larsson P. Comparison of broad-range bacterial PCR and culture of cerebrospinal fluid for diagnosis of community-acquired bacterial meningitis. Clin Microbiol Infect 2007;13:879–886.
43. Fukui MB, Williams RL, Mudigonda S. CT and MR imaging features of pyogenic ventriculitis. AJNR Am J Neuroradiol 2001;22:1510–1516.
44. Kamran S, Bener AB, Alper D, Bakshi R. Role of fluid-attenuated inversion recovery in the diagnosis of meningitis: comparison with contrast-enhanced magnetic resonance imaging. J Comput Assist Tomogr 2004;28:68–72.
45. Han KT, Choi DS, Ryoo JW, Cho JM, Jeon KN, Bae KS, You JJ, Chung SH, Koh EH, Park KJ. Diffusion-weighted MR imaging of pyogenic intraventricular empyema. Neuroradiology 2007;49:813–818.
46. Katchanov J, Siebert E, Endres M, Klingebiel R. Focal parenchymal lesions in community-acquired bacterial meningitis in adults: a clinico-radiological study. Neuroradiology 2009;51:723–729.
47. Teixeira J, Zimmerman RA, Haselgrove JC, Bilaniuk LT, Hunter JV. Diffusion imaging in pediatric central nervous system infections. Neuroradiology 2001;43:1031–1039.
48. Wong AM, Zimmerman RA, Simon EM, Pollock AN, Bilaniuk LT. Diffusion-weighted MR imaging of subdural empyemas in children. Am J Neuroradiol 2004;25:1016–1021.
49. kaplan SL. Management of pneumococcal infections. Pediatr Infect Dis J 2002;21:589–591.
50. Kaplan SL, Mason EO Jr. Management of infections due to antibiotic-resistant Streptococcus pneumoniae. Clin Microbiol Rev 1998;11:628–644.
51. Feldman WE, Ginsburg CM, McCracken GH Jr, Allen D, Ahmann P, Graham J, Graham L. Relation of concentrations of Haemophilus influenzae type b in cerebrospinal fluid to late sequelae of patients with meningitis. J Pediatr 1982;100:209–212.
52. Schaad UB, Suter S, Gianella-Borradori A, Pfenninger J, Auckenthaler R, Bernath O, Cheseaux JJ, Wedgwood J. A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children. N Engl J Med 1990;322:141–147.
53. Aronin SI, Peduzzi P, Quagliarello VJ. Community-acquired bacterial meningitis: risk stratification for adverse clinical outcome and effect of antibiotic timing. Ann Intern Med 1998;129:862–869.
54. Proulx N, Frechette D, Toye B, Chan J, Kravcik S. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM 2005;98:291–298.
55. Lepur D, Barsic B. Community-acquired bacterial meningitis in adults: antibiotic timing in disease course and outcome. Infection 2007;35:225–231.
56. Lu CH, Huang CR, Chang WN, Chang CJ, Cheng BC, Lee PY, Lin MW, Chang HW. Community-acquired bacterial meningitis in adults: the epidemiology, timing of appropriate antimicrobial therapy, and prognostic factors. Clin Neurol Neurosurg 2002;104:352–358.
57. Miner JR, Heegaard W, Mapes A, Biros M. Presentation, time to antibiotics, and mortality of patients with bacterial meningitis at an urban county medical center. J Emerg Med 2001;21:387–392.
58. Park DC, Choi IS, Heo JH, Lee KW. Acute bacterial meningitis: causative organisms, clinical characteristics and prognosis. J Korean Neurol Assoc 2000;18:556–561.
59. Kim SH, Song JH, Chung DR, Thamlikitkul V, Yang Y, Wang H, Lu M, So TM, Hsueh PR, Yasin RM, Carlos CC, Pham HV, Lalitha MK, Shimono N, Perera J, Shibl AM, Baek JY, Kang CI, Ko KS, Peck KR. ANSORP Study Group. Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. Antimicrob Agents Chemother 2012;56:1418–1426.
60. Lee SO, Ryu SH, Park SJ, Ryu J, Woo JH, Kim YS. Meningococcal disease in the republic of Korea army: incidence and serogroups determined by PCR. J Korean Med Sci 2003;18:163–166.
61. Choi JM, Cho DS, Jin SC, Kim SH, Park DB, Kim YR. Ventriculostomy-associated infection : analysis of risk factors and the venue of external ventricular drainage. Korean J Cerebrovasc Surg 2007;9:55–59.
62. Friedland IR, Klugman KP. Failure of chloramphenicol therapy in penicillin-resistant pneumococcal meningitis. Lancet 1992;339:405–408.
63. Friedland IR, McCracken GH Jr. Management of infections caused by antibiotic-resistant Streptococcus pneumoniae. N Engl J Med 1994;331:377–382.
64. Leggiadro RJ. Penicillin- and cephalosporin-resistant Streptococcus pneumoniae: an emerging microbial threat. Pediatrics 1994;93:500–503.
65. McMaster P, McIntyre P, Gilmour R, Gilbert L, Kakakios A, Mellis C. The emergence of resistant pneumococcal meningitis--implications for empiric therapy. Arch Dis Child 2002;87:207–210.
66. Quagliarello VJ, Scheld WM. Treatment of bacterial meningitis. N Engl J Med 1997;336:708–716.
67. Sáez-Llorens X, McCoig C, Feris JM, Vargas SL, Klugman KP, Hussey GD, Frenck RW, Falleiros-Carvalho LH, Arguedas AG, Bradley J, Arrieta AC, Wald ER, Pancorbo S, McCracken GH Jr, Marques SR. Trovan menigitis Study Group. Quinolone treatment for pediatric bacterial meningitis: a comparative study of trovafloxacin and ceftriaxone with or without vancomycin. Pediatr Infect Dis J 2002;21:14–22.
68. Sáez-Llorens X, O'Ryan M. Cefepime in the empiric treatment of meningitis in children. Pediatr Infect Dis J 2001;20:356–361.
69. Scholz H, Hofmann T, Noack R, Edwards DJ, Stoeckel K. Prospective comparison of ceftriaxone and cefotaxime for the short-term treatment of bacterial meningitis in children. Chemotherapy 1998;44:142–147.
70. Theilen U, Wilson L, Wilson G, Beattie JO, Qureshi S, Simpson D. Guideline Development Group. Management of invasive meningococcal disease in children and young people: summary of SIGN guidelines. BMJ 2008;336:1367–1370.
71. American Academy of Pediatrics Committee on Infectious Diseases. Therapy for children with invasive pneumococcal infections. Pediatrics 1997;99:289–299.
72. Bae S, Lee J, Kim E, Lee S, Yu J, Kang Y. Antimicrobial resistance in Haemophilus influenzae respiratory tract isolates in Korea: results of a nationwide acute respiratory infections surveillance. Antimicrob Agents Chemother 2010;54:65–71.
73. Lebel MH, Hoyt MJ, McCracken GH Jr. Comparative efficacy of ceftriaxone and cefuroxime for treatment of bacterial meningitis. J Pediatr 1989;114:1049–1054.
74. Peltola H, Anttila M, Renkonen OV. Finnish Study Group. Randomised comparison of chloramphenicol, ampicillin, cefotaxime, and ceftriaxone for childhood bacterial meningitis. Lancet 1989;1:1281–1287.
75. Sudo F, Nakamura A, Hoshino T, Ishiwada N, Kohno Y. Successful treatment of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae type b meningitis with high-dose ceftriaxone administration. Kansenshogaku Zasshi 2004;78:604–608.
76. Cherubin CE, Corrado ML, Nair SR, Gombert ME, Landesman S, Humbert G. Treatment of gram-negative bacillary meningitis: role of the new cephalosporin antibiotics. Rev Infect Dis 1982;4 Suppl:S453–S464.
77. Kaplan SL, Patrick CC. Cefotaxime and aminoglycoside treatment of meningitis caused by gram-negative enteric organisms. Pediatr Infect Dis J 1990;9:810–814.
78. Landesman SH, Corrado ML, Shah PM, Armengaud M, Barza M, Cherubin CE. Past and current roles for cephalosporin antibiotics in treatment of meningitis. Emphasis on use in gram-negative bacillary meningitis. Am J Med 1981;71:693–703.
79. Fong IW, Tomkins KB. Review of Pseudomonas aeruginosa meningitis with special emphasis on treatment with ceftazidime. Rev Infect Dis 1985;7:604–612.
80. Rodriguez WJ, Khan WN, Cocchetto DM, Feris J, Puig JR, Akram S. Treatment of Pseudomonas meningitis with ceftazidime with or without concurrent therapy. Pediatr Infect Dis J 1990;9:83–87.
81. Saez-Llorens X, Castano E, Garcia R, Baez C, Perez M, Tejeira F, McCracken GH Jr. Prospective randomized comparison of cefepime and cefotaxime for treatment of bacterial meningitis in infants and children. Antimicrob Agents Chemother 1995;39:937–940.
82. Lodise TP Jr, Nau R, Kinzig M, Jones RN, Drusano GL, Sörgel F. Comparison of the probability of target attainment between ceftriaxone and cefepime in the cerebrospinal fluid and serum against Streptococcus pneumoniae. Diagn Microbiol Infect Dis 2007;58:445–452.
83. Rousseau JM, Soullié B, Villevielle T, Koeck JL. Efficiency of cefepime in postoperative meningitis attributable to Enterobacter aerogenes. J Trauma 2001;50:971.
84. Ahmed A. A critical evaluation of vancomycin for treatment of bacterial meningitis. Pediatr Infect Dis J 1997;16:895–903.
85. Viladrich PF, Gudiol F, Liñares J, Pallarés R, Sabaté I, Rufí G, Ariza J. Evaluation of vancomycin for therapy of adult pneumococcal meningitis. Antimicrob Agents Chemother 1991;35:2467–2472.
86. Böttcher T, Gerber J, Wellmer A, Smirnov AV, Fakhrjanali F, Mix E, Pilz J, Zettl UK, Nau R. Rifampin reduces production of reactive oxygen species of cerebrospinal fluid phagocytes and hippocampal neuronal apoptosis in experimental Streptococcus pneumoniae meningitis. J Infect Dis 2000;181:2095–2098.
87. Nau R, Wellmer A, Soto A, Koch K, Schneider O, Schmidt H, Gerber J, Michel U, Brück W. Rifampin reduces early mortality in experimental Streptococcus pneumoniae meningitis. J Infect Dis 1999;179:1557–1560.
88. Spreer A, Lugert R, Stoltefaut V, Hoecht A, Eiffert H, Nau R. Short-term rifampicin pretreatment reduces inflammation and neuronal cell death in a rabbit model of bacterial meningitis. Crit Care Med 2009;37:2253–2258.
89. Aguilar J, Urday-Cornejo V, Donabedian S, Perri M, Tibbetts R, Zervos M. Staphylococcus aureus meningitis: case series and literature review. Medicine (Baltimore) 2010;89:117–125.
90. Al Kandari M, Jamal W, Udo EE, El Sayed A, Al Shammri S, Rotimi VO. A case of community-onset meningitis caused by hospital methicillin-resistant Staphylococcus aureus successfully treated with linezolid and rifampicin. Med Princ Pract 2010;19:235–239.
91. Kaufman BA. Infections of cerebrospinal fluid shunts. In: Scheld WM, Whitley RJ, Durack DT, editors. Infections of the central nervous system. 2nd ed. Philadelphia: Lippincott-Raven; 1997. pp. 555-577.
92. Orvin K, Bilavsky E, Weiner E, Shouval DS, Amir J. Successful antibiotic eradication of Streptococcus pneumoniae infection of a ventriculoatrial shunt. Int J Infect Dis 2009;13:e101–e103.
93. Bradley JS, Scheld WM. The challenge of penicillin-resistant Streptococcus pneumoniae meningitis: current antibiotic therapy in the 1990s. Clin Infect Dis 1997;24 Suppl 2:S213–S221.
94. Force E, Taberner F, Cabellos C, Ribes S, Domenech A, Tubau F, Viladrich PF, Gudiol F. Experimental study of meropenem in the therapy of cephalosporin-susceptible and -resistant pneumococcal meningitis. Eur J Clin Microbiol Infect Dis 2008;27:685–690.
95. Force E, Taberner F, Cabellos C, Ribes S, Domenech A, Tubau F, Viladrich PF, Gudiol F. Evaluation of meropenem alone and combined with rifampin in the guinea pig model of pneumococcal meningitis. Eur J Clin Microbiol Infect Dis 2009;28:807–811.
96. John CC, Aouad G, Berman B, Schreiber JR. Successful meropenem treatment of multiply resistant pneumococcal meningitis. Pediatr Infect Dis J 1997;16:1009–1011.
97. Odio CM, Puig JR, Feris JM, Khan WN, Rodriguez WJ, McCracken GH Jr, Bradley JS. Meropenem Meningitis Study Group. Prospective, randomized, investigator-blinded study of the efficacy and safety of meropenem vs. cefotaxime therapy in bacterial meningitis in children. Pediatr Infect Dis J 1999;18:581–590.
98. Schmutzhard E, Williams KJ, Vukmirovits G, Chmelik V, Pfausler B, Featherstone A. Meropenem Meningitis Study Group. A randomised comparison of meropenem with cefotaxime or ceftriaxone for the treatment of bacterial meningitis in adults. J Antimicrob Chemother 1995;36 Suppl A:85–97.
99. Buckingham SC, Davis Y, English BK. Pneumococcal susceptibility to meropenem in a mid-south children's hospital. South Med J 2002;95:1293–1296.
100. Chmelik V, Gutvirth J. Meropenem treatment of post-traumatic meningitis due to Pseudomonas aeruginosa. J Antimicrob Chemother 1993;32:922–923.
101. Nicasio AM, Quintiliani R Jr, DeRyke CA, Kuti JL, Nicolau DP. Treatment of Serratia marcescens meningitis with prolonged infusion of meropenem. Ann Pharmacother 2007;41:1077–1081.
102. Segal-Maurer S, Mariano N, Qavi A, Urban C, Rahal JJ Jr. Successful treatment of ceftazidime-resistant Klebsiella pneumoniae ventriculitis with intravenous meropenem and intraventricular polymyxin B: case report and review. Clin Infect Dis 1999;28:1134–1138.
103. Asensi F, Otero MC, Pérez-Tamarit D, Rodríguez-Escribano I, Cabedo JL, Gresa S, Cantón E. Risk/benefit in the treatment of children with imipenem-cilastatin for meningitis caused by penicillin-resistant pneumococcus. J Chemother 1993;5:133–134.
104. Asensi F, Pérez-Tamarit D, Otero MC, Gallego M, Llanes S, Abadia C, Cantó E. Imipenem-cilastatin therapy in a child with meningitis caused by a multiply resistant pneumococcus. Pediatr Infect Dis J 1989;8:895.
105. Rodriguez K, Dickinson GM, Greenman RL. Successful treatment of gram-negative bacillary meningitis with imipenem/cilastatin. South Med J 1985;78:731–732.
106. Cottagnoud P, Pfister M, Cottagnoud M, Acosta F, Täuber MG. Activities of ertapenem, a new long-acting carbapenem, against penicillin-sensitive or -resistant pneumococci in experimental meningitis. Antimicrob Agents Chemother 2003;47:1943–1947.
107. Cottagnoud PH, Täuber MG. New therapies for pneumococcal meningitis. Expert opin Investig Drugs 2004;13:393–401.
108. Schonwald S, Beus I, Lisic M, Car V, Gmajnicki B. Ciprofloxacin in the treatment of gram-negative bacillary meningitis. Am J Med 1989;87:248S–249S.
109. Djukic M, Bottcher T, Wellmer A, Gerber J, Brocke VV, Eiffert H, Nau R. Moxifloxacin in experimental Streptococcus pneumoniae cerebritis and meningitis. Neurocrit Care 2005;2:325–329.
110. Krcméry V Jr, Filka J, Uher J, Kurak H, Sagát T, Tuharský J, Novák I, Urbanová T, Kralinský K, Mateicka F, Krcméryová T, Jurga L, Sulcová M, Stencl J, Krúpová I. Ciprofloxacin in treatment of nosocomial meningitis in neonates and in infants: report of 12 cases and review. Diagn Microbiol Infect Dis 1999;35:75–80.
111. Lipman J, Allworth A, Wallis SC. Cerebrospinal fluid penetration of high doses of intravenous ciprofloxacin in meningitis. Clin Infect Dis 2000;31:1131–1133.
112. Lo WT, Wang CC, Lee CM, Chu ML. Successful treatment of multi-resistant Stenotrophomonas maltophilia meningitis with ciprofloxacin in a pre-term infant. Eur J Pediatr 2002;161:680–682.
113. Wong-Beringer A, Beringer P, Lovett MA. Successful treatment of multidrug-resistant Pseudomonas aeruginosa meningitis with high-dose ciprofloxacin. Clin Infect Dis 1997;25:936–937.
114. Graninger W, Zeitlinger M. Clinical applications of levofloxacin for severe infections. Chemotherapy 2004;50 Suppl 1:16–21.
115. Rodriguez-Cerrato V, McCoig CC, Saavedra J, Barton T, Michelow IC, Hardy RD, Bowlware K, Iglehart J, Katz K, McCracken GH Jr. Garenoxacin (BMS-284756) and moxifloxacin in experimental meningitis caused by vancomycin-tolerant pneumococci. Antimicrob Agents Chemother 2003;47:211–215.
116. Schmidt H, Dalhoff A, Stuertz K, Trostdorf F, Chen V, Schneider O, Kohlsdorfer C, Brück W, Nau R. Moxifloxacin in the therapy of experimental pneumococcal meningitis. Antimicrob Agents Chemother 1998;42:1397–1407.
117. Beer R, Engelhardt KW, Pfausler B, Broessner G, Helbok R, Lackner P, Brenneis C, Kaehler ST, Georgopoulos A, Schmutzhard E. Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains. Antimicrob Agents Chemother 2007;51:379–382.
118. Destache CJ, Pakiz CB, Larsen C, Owens H, Dash AK. Cerebrospinal fluid penetration and pharmacokinetics of levofloxacin in an experimental rabbit meningitis model. J Antimicrob Chemother 2001;47:611–615.
119. Nau R, Schmidt T, Kaye K, Froula JL, Täuber MG. Quinolone antibiotics in therapy of experimental pneumococcal meningitis in rabbits. Antimicrob Agents Chemother 1995;39:593–597.
120. Pea F, Pavan F, Nascimben E, Benetton C, Scotton PG, Vaglia A, Furlanut M. Levofloxacin disposition in cerebrospinal fluid in patients with external ventriculostomy. Antimicrob Agents Chemother 2003;47:3104–3108.
121. Scotton PG, Pea F, Giobbia M, Baraldo M, Vaglia A, Furlanut M. Cerebrospinal fluid penetration of levofloxacin in patients with spontaneous acute bacterial meningitis. Clin Infect Dis 2001;33:e109–e111.
122. Ergaz Z, Arad I, Bar-Oz B, Peleg O, Benenson S, Minster N, Moses A, Block C. Elimination of vancomycin-resistant enterococci from a neonatal intensive care unit following an outbreak. J Hosp Infect 2010;74:370–376.
123. Gattuso G, Palvarini L, Tomasoni D, Ferri F, Scalzini A. A case of community-acquired MRSA (CA-MRSA) sepsis complicated by meningoencephalitis and cerebral abscess, successfully treated with linezolid. Infez Med 2009;17:244–248.
124. Hameed N, Tunkel AR. Treatment of drug-resistant pneumococcal meningitis. Curr Infect Dis Rep 2010;12:274–281.
125. Cottagnoud P, Gerber CM, Acosta F, Cottagnoud M, Neftel K, Täuber MG. Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model. J Antimicrob Chemother 2000;46:981–985.
126. Ramírez P, Sahuquillo JM, Cortés C, Kot P, Bonastre JM. Linezolid as rescue therapy for pneumococcal meningitis. Intensive Care Med 2007;33:924–925.
127. Stahl JP. Treatment of community acquired bacterial meningitis, after microbiological identification. Med Mal Infect 2009;39:513–520.
128. Cottagnoud P, Pfister M, Acosta F, Cottagnoud M, Flatz L, Kühn F, Müller HP, Stucki A. Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis. Antimicrob Agents Chemother 2004;48:3928–3933.
129. Egermann U, Stanga Z, Ramin A, Acosta F, Stucki A, Gerber P, Cottagnoud M, Cottagnoud P. Combination of daptomycin plus ceftriaxone is more active than vancomycin plus ceftriaxone in experimental meningitis after addition of dexamethasone. Antimicrob Agents Chemother 2009;53:3030–3033.
130. Gerber P, Stucki A, Acosta F, Cottagnoud M, Cottagnoud P. Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis. J Antimicrob Chemother 2006;57:720–723.
131. Grandgirard D, Oberson K, Buhlmann A, Gaumann R, Leib SL. Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. Antimicrob Agents Chemother 2010;54:1323–1326.
132. Grandgirard D, Schurch C, Cottagnoud P, Leib SL. Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. Antimicrob Agents Chemother 2007;51:2173–2178.
133. Mook-Kanamori BB, Rouse MS, Kang CI, van de Beek D, Steckelberg JM, Patel R. Daptomycin in experimental murine pneumococcal meningitis. BMC Infect Dis 2009;9:50.
134. Stucki A, Cottagnoud M, Winkelmann V, Schaffner T, Cottagnoud P. Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H] choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall. Antimicrob Agents Chemother 2007;51:2249–2252.
135. Ellis-Pegler R, Galler L, Roberts S, Thomas M, Woodhouse A. Three days of intravenous benzyl penicillin treatment of meningococcal disease in adults. Clin Infect Dis 2003;37:658–662.
136. Martin E, Hohl P, Guggi T, Kayser FH, Fernex M. Short course single daily ceftriaxone monotherapy for acute bacterial meningitis in children: results of a Swiss multicenter study. Part I: Clinical results. Infection 1990;18:70–77.
137. Roine I, Ledermann W, Foncea LM, Banfi A, Cohen J, Peltola H. Randomized trial of four vs. seven days of ceftriaxone treatment for bacterial meningitis in children with rapid initial recovery. Pediatr Infect Dis J 2000;19:219–222.
138. Singhi P, Kaushal M, Singhi S, Ray P. Seven days vs. 10 days ceftriaxone therapy in bacterial meningitis. J Trop Pediatr 2002;48:273–279.
139. Lin TY, Chrane DF, Nelson JD, McCracken GH Jr. Seven days of ceftriaxone therapy is as effective as ten days' treatment for bacterial meningitis. JAMA 1985;253:3559–3563.
140. Marks WA, Stutman HR, Marks MI, Abramson JS, Ayoub EM, Chartrand SA, Cox FE, Geffen WA, Harrison CJ, Harrison D, Paryani S, Tolpin MD. Cefuroxime versus ampicillin plus chloramphenicol in childhood bacterial meningitis: a multicenter randomized controlled trial. J Pediatr 1986;109:123–130.
141. Hervas JA, Fiol M, Cuesta M. Nonneonatal relapsing meningitis caused by Listeria monocytogenes. Pediatr Infect Dis 1986;5:721.
142. Niklasson PM, Hambraeus A, Lundgren G, Magnusson G, Sundelin P, Groth CG. Listeria encephalitis in five renal transplant recipients. Acta Med Scand 1978;203:181–185.
143. Scheer MS, Hirschman SZ. Oral and ambulatory therapy of Listeria bacteremia and meningitis with trimethoprim-sulfamethoxazole. Mt Sinai J Med 1982;49:411–414.
144. Lu CH, Chang WN, Chuang YC, Chang HW. The prognostic factors of adult gram-negative bacillary meningitis. J Hosp Infect 1998;40:27–34.
145. Mancebo J, Domingo P, Blanch L, Coll P, Net A, Nolla J. Post-neurosurgical and spontaneous gram-negative bacillary meningitis in adults. Scand J Infect Dis 1986;18:533–538.
146. O'Neill E, Humphreys H, Phillips J, Smyth EG. Third-generation cephalosporin resistance among Gram-negative bacilli causing meningitis in neurosurgical patients: significant challenges in ensuring effective antibiotic therapy. J Antimicrob Chemother 2006;57:356–359.
147. van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004;351:1849–1859.
148. van de Beek D, de Gans J, Tunkel AR, Wijdicks EF. Community-acquired bacterial meningitis in adults. N Engl J Med 2006;354:44–53.
149. van de Beek D, Schmand B, de Gans J, Weisfelt M, Vaessen H, Dankert J, Vermeulen M. Cognitive impairment in adults with good recovery after bacterial meningitis. J Infect Dis 2002;186:1047–1052.
150. Weisfelt M, de Gans J, van der Poll T, van de Beek D. Pneumococcal meningitis in adults: new approaches to management and prevention. Lancet Neurol 2006;5:332–342.
151. McIntyre PB, Berkey CS, King SM, Schaad UB, Kilpi T, Kanra GY, Perez CM. Dexamethasone as adjunctive therapy in bacterial meningitis. A meta-analysis of randomized clinical trials since 1988. JAMA 1997;278:925–931.
152. van de Beek D, de Gans J, McIntyre P, Prasad K. Corticosteroids in acute bacterial meningitis. Cochrane Database Syst Rev 2003:CD004405.
153. de Gans J, van de Beek D. European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators. Dexamethasone in adults with bacterial meningitis. N Engl J Med 2002;347:1549–1556.
154. Cabellos C, Martínez-Lacasa J, Tubau F, Fernández A, Viladrich PF, Liñares J, Gudiol F. Evaluation of combined ceftriaxone and dexamethasone therapy in experimental cephalosporin-resistant pneumococcal meningitis. J Antimicrob Chemother 2000;45:315–320.
155. Klugman KP, Friedland IR, Bradley JS. Bactericidal activity against cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis. Antimicrob Agents Chemother 1995;39:1988–1992.
156. Ricard JD, Wolff M, Lacherade JC, Mourvillier B, Hidri N, Barnaud G, Chevrel G, Bouadma L, Dreyfuss D. Levels of vancomycin in cerebrospinal fluid of adult patients receiving adjunctive corticosteroids to treat pneumococcal meningitis: a prospective multicenter observational study. Clin Infect Dis 2007;44:250–255.
157. Nguyen TH, Tran TH, Thwaites G, Ly VC, Dinh XS, Ho Dang TN, Dang QT, Nguyen DP, Nguyen HP, To SD, Nguyen VC, Nguyen MD, Campbell J, Schultsz C, Parry C, Torok ME, White N, Nguyen TC, Tran TH, Stepniewska K, Farrar JJ. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. N Engl J Med 2007;357:2431–2440.
158. Scarborough M, Gordon SB, Whitty CJ, French N, Njalale Y, Chitani A, Peto TE, Lalloo DG, Zijlstra EE. Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa. N Engl J Med 2007;357:2441–2450.
159. Brouwer MC, McIntyre P, de Gans J, Prasad K, van de Beek D. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev 2010:CD004405.
160. Moon SY, Chung DR, Kim SW, Chang HH, Lee H, Jung DS, Kim YS, Jung SI, Ryu SY, Heo ST, Moon C, Ki HK, Son JS, Kwon KT, Shin SY, Lee JS, Lee SS, Rhee JY, Kang CI, Peck KR, Song JH. Is adjunctive corticosteroid beneficial in pneumococcal meningitis in a region with high rates of resistance to penicillin and ceftriaxone? J Neurol. 2012 Jan 06;
(in press).
161. Nadel S, Kroll JS. Diagnosis and management of meningococcal disease: the need for centralized care. FEMS Microbiol Rev 2007;31:71–83.
162. Kilpi T, Peltola H, Jauhiainen T, Kallio MJ. The Finnish Study Group. Oral glycerol and intravenous dexamethasone in preventing neurologic and audiologic sequelae of childhood bacterial meningitis. Pediatr Infect Dis J 1995;14:270–278.
163. Lorenzl S, Koedel U, Pfister HW. Mannitol, but not allopurinol, modulates changes in cerebral blood flow, intracranial pressure, and brain water content during pneumococcal meningitis in the rat. Crit Care Med 1996;24:1874–1880.
164. Peltola H, Roine I, Fernández J, Zavala I, Ayala SG, Mata AG, Arbo A, Bologna R, Miño G, Goyo J, López E, de Andrade SD, Sarna S. Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial. Clin Infect Dis 2007;45:1277–1286.
165. Singhi S, Järvinen A, Peltola H. Increase in serum osmolality is possible mechanism for the beneficial effects of glycerol in childhood bacterial meningitis. Pediatr Infect Dis J 2008;27:892–896.
166. Syrogiannopoulos GA, Olsen KD, McCracken GH Jr. Mannitol treatment in experimental Haemophilus influenzae type b meningitis. Pediatr Res 1987;22:118–122.
167. Minns RA, Engleman HM, Stirling H. Cerebrospinal fluid pressure in pyogenic meningitis. Arch Dis Child 1989;64:814–820.
168. Baek MY, Kim YM, Lee YJ, Nam SO. Risk factors of epilepsy after central nervous system infection in children. J Korean Child Neurol Soc 2010;18:33–39.
169. Cabellos C, Verdaguer R, Olmo M, Fernández-Sabé N, Cisnal M, Ariza J, Gudiol F, Viladrich PF. Community-acquired bacterial meningitis in elderly patients: experience over 30 years. Medicine (Baltimore) 2009;88:115–119.
170. Chang CJ, Chang HW, Chang WN, Huang LT, Huang SC, Chang YC, Hung PL, Chang CS, Chuang YC, Huang CR, Tsai NW, Tsui HW, Wang KW, Lu CH. Seizures complicating infantile and childhood bacterial meningitis. Pediatr Neurol 2004;31:165–171.
171. Wang KW, Chang WN, Chang HW, Chuang YC, Tsai NW, Wang HC, Lu CH. The significance of seizures and other predictive factors during the acute illness for the long-term outcome after bacterial meningitis. Seizure 2005;14:586–592.
172. Zoons E, Weisfelt M, de Gans J, Spanjaard L, Koelman JH, Reitsma JB, van de Beek D. Seizures in adults with bacterial meningitis. Neurology 2008;70:2109–2115.
173. Bianchetti MG, Thyssen HR, Laux-End R, Schaad UB. Evidence for fluid volume depletion in hyponatraemic patients with bacterial meningitis. Acta Paediatr 1996;85:1163–1166.
174. Singhi SC, Singhi PD, Srinivas B, Narakesri HP, Ganguli NK, Sialy R, Walia BN. Fluid restriction does not improve the outcome of acute meningitis. Pediatr Infect Dis J 1995;14:495–503.
175. Tauber MG, San de E, Fournier MA, Tureen JH, Sande MA. Fluid administration, brain edema, and cerebrospinal fluid lactate and glucose concentrations in experimental Escherichia coli meningitis. J Infect Dis 1993;168:473–476.
176. Ziai WC, Lewin JJ 3rd. Improving the role of intraventricular antimicrobial agents in the management of meningitis. Curr Opin Neurol 2009;22:277–282.
177. Kestle JR, Garton HJ, Whitehead WE, Drake JM, Kulkarni AV, Cochrane DD, Muszynski C, Walker ML. Management of shunt infections: a multicenter pilot study. J Neurosurg 2006;105 3 Suppl:177–181.
178. Tunkel AR, Kaufman BA. Cerebrospinal fluid shunt infections. In: Mandell GL, Bennet JE, Dolin R, editors. Principles and Practice of Infectious Diseases. 6 ed. Philadelphia: Elsevier Inc.; 2005. pp. 1126-1132.
179. Bilukha OO, Rosenstein N. National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC). Prevention and control of meningococcal disease. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2005;54:1–21.
180. Korea Centers for Disease Control and Prevention. Current status of selected infectious diseases. Public Health Weekly Report 2012;4:961–967.
181. Kristiansen BE, Tveten Y, Jenkins A. Which contacts of patients with meningococcal disease carry the pathogenic strain of Neisseria meningitidis? A population based study. BMJ 1998;317:621–625.
182. Meningococcal disease. Secondary attack rate and chemoprophylaxis in the United States, 1974. JAMA 1976;235:261–265.
183. Analysis of endemic meningococcal disease by serogroup and evaluation of chemoprophylaxis. J Infect Dis 1976;134:201–204.
184. De Wals P, Hertoghe L, Borlée-Grimée I, De Maeyer-Cleempoel S, Reginster-Haneuse G, Dachy A, Bouckaert A, Lechat MF. Meningococcal disease in Belgium. Secondary attack rate among household, day-care nursery and pre-elementary school contacts. J Infect 1981;3 1 Suppl:53–61.
185. Purcell B, Samuelsson S, Hahné SJ, Ehrhard I, Heuberger S, Camaroni I, Charlett A, Stuart JM. Effectiveness of antibiotics in preventing meningococcal disease after a case: systematic review. BMJ 2004;328:1339.
186. Jacobson JA, Filice GA, Holloway JT. Meningococcal disease in day-care centers. Pediatrics 1977;59:299–300.
187. PHLS Meningococcal Infections Working Group and Public Health Medicine Environmental Group. Control of meningococcal disease: guidance for consultants in communicable disease control. Commun Dis Rep CDR Rev 1995;5:R189–R195.
188. Guidelines for the management of airline passengers exposed to meningococcal disease. Centers for Diseases Control and Prevention. 2000 [Accessed 11 March 2012].
189. Edwards EA, Devine LF, Sengbusch GH, Ward HW. Immunological investigations of meningococcal disease. III. Brevity of group C acquisition prior to disease occurrence. Scand J Infect Dis 1977;9:105–110.
190. Gardner P. Clinical practice. Prevention of meningococcal disease. N Engl J Med 2006;355:1466–1473.
191. Dworzack DL, Sanders CC, Horowitz EA, Allais JM, Sookpranee M, Sanders WE Jr, Ferraro FM. Evaluation of single-dose ciprofloxacin in the eradication of Neisseria meningitidis from nasopharyngeal carriers. Antimicrob Agents Chemother 1988;32:1740–1741.
192. Schwartz B, Al-Tobaiqi A, Al-Ruwais A, Fontaine RE, A'Ashi J, Hightower AW, Broome CV, Music SI. Comparative efficacy of ceftriaxone and rifampicin in eradicating pharyngeal carriage of group A Neisseria meningitidis. Lancet 1988;1:1239–1242.
193. Gaunt PN, Lambert BE. Single dose ciprofloxacin for the eradication of pharyngeal carriage of Neisseria meningitidis. J Antimicrob Chemother 1988;21:489–496.
194. Girgis N, Sultan Y, Frenck RW Jr, El-Gendy A, Farid Z, Mateczun A. Azithromycin compared with rifampin for eradication of nasopharyngeal colonization by Neisseria meningitidis. Pediatr Infect Dis J 1998;17:816–819.
195. Pittman M. Variation and type specificcity in the bacterial species Hemophilus influenzae. J Exp Med 1931;53:471–492.
196. Peltola H. Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates. Clin Microbiol Rev 2000;13:302–317.
197. Cho HK, Lee H, Kang JH, Kim KN, Kim DS, Kim YK, Kim JS, Kim JH, Kim CH, Kim HM, Park SE, Oh SH, Chung EH, Cha SH, Choi YY, Hur JK, Hong YJ, Lee HJ, Kim KH. The causative organisms of bacterial meningitis in Korean children in 1996-2005. J Korean Med Sci 2010;25:895–899.
198. Kim KH, Sohn YM, Kang JH, Kim KN, Kim DS, Kim JH, Kim CH, Shin YK, Oh SH, Lee HJ, Cha SH, Hong YJ, Sohn KC. The causative organisms of bacterial meningitis in Korean children, 1986-1995. J Korean Med Sci 1998;13:60–64.
199. Goldwater PN. Effect of cefotaxime or ceftriaxone treatment on nasopharyngeal Haemophilus influenzae type b colonization in children. Antimicrob Agents Chemother 1995;39:2150–2152.
200. Ladhani S, Neely F, Heath PT, Nazareth B, Roberts R, Slack MP, McVernon J, Ramsay ME. Recommendations for the prevention of secondary Haemophilus influenzae type b (Hib) disease. J Infect 2009;58:3–14.
201. Sumaraju V, Smith LG, Smith SM. Infectious complications in asplenic hosts. Infect Dis Clin North Am 2001;15:551–565.
202. Ward JI, Fraser DW, Baraff LJ, Plikaytis BD. Haemophilus influenzae meningitis. A national study of secondary spread in household contacts. N Engl J Med 1979;301:122–126.
203. Cox F, Trincher R, Rissing JP, Patton M, McCracken GH Jr, Granoff DM. Rifampin prophylaxis for contacts of Haemophilus influenzae type b disease. JAMA 1981;245:1043–1045.
204. McVernon J, Howard AJ, Slack MP, Ramsay ME. Long-term impact of vaccination on Haemophilus influenzae type b (Hib) carriage in the United Kingdom. Epidemiol Infect 2004;132:765–767.